| Budget Amount *help |
¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
We have studied the total synthesis of bioactive natural products via integrated reactions developed by focusing our attention on reactive intermediates. (1)Anion: Total syntheses of (-)-scabronines G, A, D, and (-)-episcabronine A have been achieved. Highly stereoselective Michael reaction cascades have been developed. (2)Cation: A formal enantioselective total synthesis of (-)-taxol and a first total synthesis of (+)-ophiobolin A have been achieved. (3)Transition metal: Total synthesis of hyperforin, formal enantioselective total syntheses of nemorosone, garsubellin A, and clusianone have been achieved. A first non-heme Fe(III) complex that catalyzes highly enantioselective asymmetric epoxidation has been synthesized. A first enantioselective total synthesis of (+)-colletoic acid, formal total syntheses of (-)-platencin and (-)-platensimycin, integrated syntheses of a-alkylidene b-keto imide, highly enantioselective [4+2]cycloaddition and Hosomi-Sakurai reaction have been achieved.
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