|Budget Amount *help
¥241,280,000 (Direct Cost: ¥185,600,000、Indirect Cost: ¥55,680,000)
Fiscal Year 2013: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2012: ¥39,520,000 (Direct Cost: ¥30,400,000、Indirect Cost: ¥9,120,000)
Fiscal Year 2011: ¥73,060,000 (Direct Cost: ¥56,200,000、Indirect Cost: ¥16,860,000)
Fiscal Year 2010: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2009: ¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Cells in early mouse embryos make a community by communicating each other. In this study, we focused on the Hippo signaling pathway and analyzed the roles and underlying mechanisms of cell-cell contacts in regulation of this cellular community, and made following achievements: mechanisms of position-dependent cell fate specification in preimplantation embryos, mechanisms of cell density sensing by a cell, establishment of live imaging system for post-implantation embryos, identification of the importance of the mechanical forces generated by extra-embryonic tissues for notochord morphogenesis, establishment of the systems for analyses of inter-cellular communication in cultured cells and in post-implantation embryos, mechanisms by which Sall4 maintains primordial germ cells, and induction of three-dimensional kidney tissues from stem cells through identification of developmental origin of kidney cells.