| Budget Amount *help |
¥235,560,000 (Direct Cost: ¥181,200,000、Indirect Cost: ¥54,360,000)
Fiscal Year 2013: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2012: ¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000)
Fiscal Year 2011: ¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2010: ¥60,710,000 (Direct Cost: ¥46,700,000、Indirect Cost: ¥14,010,000)
Fiscal Year 2009: ¥55,900,000 (Direct Cost: ¥43,000,000、Indirect Cost: ¥12,900,000)
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| Outline of Final Research Achievements |
During early mammalian development, the behaviors of cells, regulation of cell differentiation and patterns of gene expression are variable. It has not been uncovered how cell differentiation, formation of body axes and shapes of embryo are regulated in the cellular community within an embryo. We have been studying to reveal mechanisms underlying these regulations. We found the regulating mechanisms for cell differentiations are different depending on the steps of differentiation. Detailed molecular interaction was revealed by the analyses using embryonic stem cells. We established a series of transgenic mouse lines to visualize organelles with fluorescent proteins. We also developed new microscope systems for the live imaging of developing mouse embryos. Monoclonal antibodies against molecules expressed in mouse blastocyst were made, and the micro devices were developed for the screening of antibodies by immunostaining of blastocysts.
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