HOMEOSTATIC INFLAMMATION IN DROSOPHILA

• Project Area: Homeostatic inflammation: Molecular basis and dysregulation
• Project/Area Number: 21117005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: KURATA SHOICHIRO 東北大学, 薬学研究科(研究院), 教授 (90221944)
• Project Period (FY): 2009-07-23 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥159,250,000 (Direct Cost: ¥122,500,000、Indirect Cost: ¥36,750,000); Fiscal Year 2013: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000); Fiscal Year 2012: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000); Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000); Fiscal Year 2010: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000); Fiscal Year 2009: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
• Keywords: 自然炎症 / 病原体センサー / ショウジョウバエ / コシャペロン様因子 / メラニン化 / 自然免疫 / 新規受容体 / cGMP / Toll経路

Research Abstract

In this study, we investigated the molecular mechanisms of homeostatic inflammation focusing on three items (1) new receptor, Gyc76C, and its endogenous ligand, (2) pathogen sensor, PGRP-LE,-dependent induction of homeostatic inflammation, and (3) PGRP-LE-dependent autophagy induction, using Drosophila as a model system.

Research Products

• [Journal Article] Peptidoglycan recognition proteins in Drosophila immunity (2014)
  • Author(s): Kurata, S.:
  • Journal Title: Dev. Comp. Immunol. Volume: 42 Issue: 1 Pages: 36-41
  • DOI: 10.1016/j.dci.2013.06.006
  • Peer Reviewed
• [Journal Article] Terresterol, a Polyoxygenated Lanostanoid, Isolated from the Oomycete Saprolegnia terrestris, and Its Innate Immune-Promoting Activity (2013)
  • Author(s): Kikuchi, H., Sato, Y., Kurata, S., Katou, Y., Oshima, Y.
  • Journal Title: Tetrahedron Volume: 69 Issue: 17 Pages: 3536-3542
  • DOI: 10.1016/j.tet.2013.02.088
  • Peer Reviewed
• [Journal Article] Host-microbe interactions in the gut of Drosophila melanogaster (2013)
  • Author(s): Kuraishi, T., Hori, A., Kurata, S.
  • Journal Title: Frot. Physiol. Volume: 4 Pages: 375-375
  • DOI: 10.3389/fphys.2013.00375
  • Peer Reviewed
• [Journal Article] Ectopic Antenna Induction by Overexpression of <i>CG17836/Xrp1</i> Encoding an AT-Hook DNA Binding Motif Protein in <i>Drosophila</i> (2013)
  • Author(s): Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Tomonori Katsuyama, Tatsurou Minami, Hirofumi Furuhashi, Yoshiteru Oshima, and Shoichiro Kurata
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 77 Issue: 2 Pages: 339-344
  • DOI: 10.1271/bbb.120756
  • NAID: 10031164738
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress (2012)
  • Author(s): Tsuzuki, S., Ochiai, M., Matsumoto, H., Kurata, S., Ohnishi A., Hayakawa, Y.
  • Journal Title: Sci. Rep. Volume: 2 Issue: 1 Pages: 210-210
  • DOI: 10.1038/srep00210
  • Peer Reviewed
• [Journal Article] New Dimeric and Monomeric Chromanones, Gonytolides D-G, Isolated from the Fungus Gonytrichum sp (2012)
  • Author(s): Kikuchi, H., Isobe, M., Kurata, S., Katou, Y., Oshima, Y.
  • Journal Title: Tetrahedron Volume: 68 Issue: 31 Pages: 6218-6223
  • DOI: 10.1016/j.tet.2012.05.064
  • Peer Reviewed
• [Journal Article] Coleopteran antimicrobial peptides : Prospects for clinical applications (2012)
  • Author(s): Ntwasa, M., Goto, A., Kurata, S.
  • Journal Title: Special Issue on "Antimicrobial Peptides as Therapeutic Agents" International Journal of Microbiology Volume: (Article ID 101989) Pages: 1-8
  • DOI: 10.1155/2012/101989
  • Peer Reviewed
• [Journal Article] Synthesis and Innate Immunosuppressive Effect of 1,2-Cyclopentanediol Derivatives (2011)
  • Author(s): Kikuchi, H., Okazaki, K., Sekiya, M., Uryu, Y., Ueda, K., Katou, Y., Kurata, S. Oshima, Y.
  • Journal Title: Eur. J. Med. Chem. Volume: 46 Pages: 1263-1273
  • Peer Reviewed
• [Journal Article] A phytoceramide analog stimulates the production of chemokines through CREB activation in human endothelial cells (2011)
  • Author(s): Sekiya, M., Ueda, K., Okazaki, K., Terashima, J., Katou,Y., Kikuchi, H., Kurata, S., Oshima, Y.
  • Journal Title: Int. Immunopharmacol. Volume: 11 Pages: 1497-1503
  • Peer Reviewed
• [Journal Article] Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses (2011)
  • Author(s): Kikuchi, H., Isobe, M., Sekiya, M., Abe, Y., Hoshikawa, T., Ueda, K., Kurata, S., Katou, Y., Oshima, Y.
  • Journal Title: Org. Lett. Volume: 13 Pages: 4624-4627
  • Peer Reviewed
• [Journal Article] Intracellular Recognition of Pathogens and Autophagy as an Innate Immune Host Defense (2011)
  • Author(s): Yano, T., Kurata, S.
  • Journal Title: J. Biochem. Volume: 150 Pages: 143-149
  • Peer Reviewed
• [Journal Article] Synthesis and Innate Immunosuppressive Effect of 1,2-Cyclopentanediol Derivatives (2011)
  • Author(s): Kikuchi, H., Okazaki, K., Sekiya, M., Uryu, Y., Ueda, K., Katou, Y., Kurata, S., Oshima, Y
  • Journal Title: Eur.J.Med.Chem. Volume: 46 Pages: 1263-1273
  • Peer Reviewed
• [Journal Article] Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp.and their promoting activities of innate immune responses (2011)
  • Author(s): Kikuchi, H., Isobe, M., Sekiya, M., Abe, Y.,Hoshikawa, T., Ueda, K., Kurata, S., Katou, Y., Oshima, Y.
  • Journal Title: Org.Lett. Volume: 13 Pages: 4624-4627
  • Peer Reviewed
• [Journal Article] 自然免疫機構を利用した感染制御 (2011)
  • Author(s): 倉田祥一朗、後藤彰
  • Journal Title: 遺伝 Volume: 65 Pages: 21-26
• [Journal Article] Cooperative regulation of the induction of the novel antibacterial listericin by PGRP-LE and the JAK-STAT pathway (2010)
  • Author(s): Goto, A., Yano, T., Terashima, J., Iwashita, S., Oshima, Y. Kurata, S.
  • Journal Title: J. Biol. Chem. Volume: 285 Pages: 15731-15738
  • Peer Reviewed
• [Journal Article] Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC (2010)
  • Author(s): Kurata, S.
  • Journal Title: Int. Immunol. Volume: 22 Pages: 143-148
  • NAID: 10027391539
  • Peer Reviewed
• [Journal Article] Cooperative regulation of the induction of the novel antibacterial listericin by PGRP-LE and the JAK-STAT pathway (2010)
  • Author(s): Goto, A., Yano, T., Terashima, J., Iwashita, S., Oshima, Y., Kurata, S.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 15731-15738
  • Peer Reviewed
• [Journal Article] Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC (2010)
  • Author(s): Kurata, S.
  • Journal Title: Int.Immunol. Volume: 42 Pages: 143-148
  • NAID: 10027391539
  • Peer Reviewed
• [Journal Article] ショウジョウバエ病原体センサーPGRP-LEによる炎症誘導とオートファジー誘導 (2010)
  • Author(s): 倉田祥一朗
  • Journal Title: 炎症と免疫 Volume: 18 Pages: 3-7
• [Journal Article] An unexpected twist for autophagy in Crohn's desease (2009)
  • Author(s): Yano, T., Kurata, S.
  • Journal Title: Nature Immunol. Volume: 10 Pages: 134-136
  • Peer Reviewed
• [Journal Article] New diterpene pyrone-type compounds, metarhizins A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their inhibitory effects on cellular proliferation (2009)
  • Author(s): Kikuchi, H., Hoshi, T., Kitayama, M., Sekiya, M., Katou, Y., Ueda, K., Kubohara, Y., Sato, H., Shimazu, M., Kurata, S., Oshima, Y.
  • Journal Title: Tetrahedron Volume: 65 Pages: 469-477
  • Peer Reviewed
• [Journal Article] Revised Structure and Synthesis of Celastramycin A, a Potent Innate Immune Suppressor (2009)
  • Author(s): Kikuchi, H., Sekiya, M., Katou, Y., Ueda, K., Kabeya, T., Kurata, S., Oshima, Y.
  • Journal Title: Organic letters Volume: 11 Pages: 1693-1695
  • Peer Reviewed
• [Journal Article] An unexpected twist for autophagy in Crohn's desease. (2009)
  • Author(s): Yano, T., Kurata, S
  • Journal Title: Nature Immunology Volume: 10 Pages: 134-136
  • Peer Reviewed
• [Journal Article] 昆虫の自然免疫機構を解き明かす (2009)
  • Author(s): 倉田祥一朗
  • Journal Title: 化学 Volume: 64 Pages: 12-17
• [Journal Article] ショウジョウバエモデルによる病原細菌認識と排除の分子機構 (2009)
  • Author(s): 倉田祥一朗
  • Journal Title: 実験医学増刊「感染症のサイエンス」 Volume: 27 Pages: 212-217
• [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity (2014)
  • Author(s): 倉田祥一朗
  • Organizer: Glasgow Epitheliome meeting in April 2014
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2014-04-23
  • Invited
• [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity (2014)
  • Author(s): 倉田祥一朗
  • Organizer: Asian invertebrate immunity symposium 2013
  • Place of Presentation: Busan, Korea
  • Year and Date: 2014-02-14
  • Invited
• [Presentation] Recognition of microbes and regulation of innate immunity (2014)
  • Author(s): Shoichiro Kurata
  • Organizer: KVA-JSPS Seminar
  • Place of Presentation: Sweden: Uppsala, Umea Stockholm, and Finland: Tampere
  • Invited
• [Presentation] A receptor-type guanylate cyclase mediates humoral and cellular responses in Drosophila immunity (2013)
  • Author(s): 倉田祥一朗
  • Organizer: EMBO-ESF Research Conference on Integrated Insect Immunology: From Basic Biology To Environmental Applications
  • Place of Presentation: Pultusk, Poland
  • Year and Date: 2013-09-23
  • Invited
• [Presentation] A receptor-type guanylate cyclase mediates humoral and cellular responses in Drosophila immunity (2013)
  • Author(s): Shoichiro Kurata
  • Organizer: EMBO-ESF Research Conference “Integrated Insect Immunology: From Basic Biology To Environmental Applications”
  • Place of Presentation: Pultusk, Poland.
  • Invited
• [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity (2012)
  • Author(s): 倉田祥一朗
  • Organizer: XXIV International Congress of Entomology
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2012-08-19
  • Invited
• [Presentation] Plenary lecture. New Toll gate for humoral and cellular immune response in Drosophila (2012)
  • Author(s): 倉田祥一朗
  • Organizer: The 12th Congress of the International Society of Developmental and Comparative Immunology
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2012-07-09
  • Invited
• [Presentation] New Toll gate for humoral and cellular immune response in Drosophila (2012)
  • Author(s): Shoichiro Kurata
  • Organizer: The 12th Congress of the International Society of Developmental and Comparative Immunology
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2012-07-09
  • Invited
• [Presentation] A receptor guanylyl cyclase mediates humoral and cellular responses in Drosophila immunity (2011)
  • Author(s): 倉田祥一朗
  • Organizer: 8^<th> International Congress of Comparative Physiology and Biochemistry
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-06-03
• [Presentation] A receptor guanylyl cyclase mediates humoral and cellular responses in Drosophila immunity (2011)
  • Author(s): 倉田祥一朗
  • Organizer: 8th International Congress of Comparative Physiology and Biochemistry
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2011-05-31
  • Invited
• [Presentation] Innate immune responses in Drosophila (2010)
  • Author(s): 倉田祥一朗
  • Organizer: International symposium on Deciphering a link between pathogen sensors and inflammatory diseases
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-07-28
  • Invited
• [Presentation] Recognition of intracellular bacterial infections and induction of autophagy in Drosophila immunity (2010)
  • Author(s): 倉田祥一朗
  • Organizer: The 2010 Gordon Research Conference on Autophagy in Stress, Development & Disease
  • Place of Presentation: Lucca (Barga), Italy
  • Year and Date: 2010-04-25
  • Invited
• [Presentation] Intracellular bacterial recognition and induction of immune responses in Drosophila (2010)
  • Author(s): 倉田祥一朗
  • Organizer: The STINT workshop
  • Place of Presentation: Uppsala, Sweden
  • Year and Date: 2010-03-15
  • Invited
• [Presentation] Recognition of intracellular bacterial infections and induction of autophagy in Drosophila immunity (2010)
  • Author(s): Kurata, S.
  • Organizer: The 2010 Gordon Research Conference on Autophagy in Stress, Development&Disease
  • Place of Presentation: Lucca (Barga), Italy(招待講演)
• [Presentation] Induction of autophagy via intracellular innate immune recognition in Drosophila (2009)
  • Author(s): 倉田祥一朗
  • Organizer: 5th International Symposium on Autophagy
  • Place of Presentation: Otsu, Japan
  • Year and Date: 2009-09-24
  • Invited
• [Presentation] Induction of autophagy via intracellular innate immune recognition in Drosophila (2009)
  • Author(s): 倉田祥一朗
  • Organizer: CNRS meeting "Insect immunity in action"
  • Place of Presentation: Aussois, France
  • Year and Date: 2009-05-23
  • Invited
• [Presentation] Induction of autophagy via intracellular innate immune recognition in Drosophila (2009)
  • Author(s): 倉田祥一朗
  • Organizer: The 66th KABMB annual meeting
  • Place of Presentation: C0EX, Korea
  • Year and Date: 2009-05-12
  • Invited
• [Book] Invertebrate Immunity (2010)
  • Author(s): Kenneth Soderhall (Ed.)
  • Publisher: Landes Bioscience and Springer Science+Business Media
• [Remarks]
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html
• [Remarks] 生命機能解析学分野
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html
• [Remarks] 生命機能解析学分野
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html