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HOMEOSTATIC INFLAMMATION IN DROSOPHILA

Planned Research

Project AreaHomeostatic inflammation: Molecular basis and dysregulation
Project/Area Number 21117005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

KURATA SHOICHIRO  東北大学, 薬学研究科(研究院), 教授 (90221944)

Project Period (FY) 2009-07-23 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥159,250,000 (Direct Cost: ¥122,500,000、Indirect Cost: ¥36,750,000)
Fiscal Year 2013: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
Fiscal Year 2012: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2010: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
Fiscal Year 2009: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Keywords自然炎症 / 病原体センサー / ショウジョウバエ / コシャペロン様因子 / メラニン化 / 自然免疫 / 新規受容体 / cGMP / Toll経路
Research Abstract

In this study, we investigated the molecular mechanisms of homeostatic inflammation focusing on three items (1) new receptor, Gyc76C, and its endogenous ligand, (2) pathogen sensor, PGRP-LE,-dependent induction of homeostatic inflammation, and (3) PGRP-LE-dependent autophagy induction, using Drosophila as a model system.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (46 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (25 results) (of which Peer Reviewed: 21 results) Presentation (17 results) (of which Invited: 15 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Peptidoglycan recognition proteins in Drosophila immunity2014

    • Author(s)
      Kurata, S.:
    • Journal Title

      Dev. Comp. Immunol.

      Volume: 42 Issue: 1 Pages: 36-41

    • DOI

      10.1016/j.dci.2013.06.006

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Terresterol, a Polyoxygenated Lanostanoid, Isolated from the Oomycete Saprolegnia terrestris, and Its Innate Immune-Promoting Activity2013

    • Author(s)
      Kikuchi, H., Sato, Y., Kurata, S., Katou, Y., Oshima, Y.
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 17 Pages: 3536-3542

    • DOI

      10.1016/j.tet.2013.02.088

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Host-microbe interactions in the gut of Drosophila melanogaster2013

    • Author(s)
      Kuraishi, T., Hori, A., Kurata, S.
    • Journal Title

      Frot. Physiol.

      Volume: 4 Pages: 375-375

    • DOI

      10.3389/fphys.2013.00375

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic Antenna Induction by Overexpression of <i>CG17836/Xrp1</i> Encoding an AT-Hook DNA Binding Motif Protein in <i>Drosophila</i>2013

    • Author(s)
      Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Tomonori Katsuyama, Tatsurou Minami, Hirofumi Furuhashi, Yoshiteru Oshima, and Shoichiro Kurata
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 2 Pages: 339-344

    • DOI

      10.1271/bbb.120756

    • NAID

      10031164738

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress2012

    • Author(s)
      Tsuzuki, S., Ochiai, M., Matsumoto, H., Kurata, S., Ohnishi A., Hayakawa, Y.
    • Journal Title

      Sci. Rep.

      Volume: 2 Issue: 1 Pages: 210-210

    • DOI

      10.1038/srep00210

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Dimeric and Monomeric Chromanones, Gonytolides D-G, Isolated from the Fungus Gonytrichum sp2012

    • Author(s)
      Kikuchi, H., Isobe, M., Kurata, S., Katou, Y., Oshima, Y.
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 31 Pages: 6218-6223

    • DOI

      10.1016/j.tet.2012.05.064

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coleopteran antimicrobial peptides : Prospects for clinical applications2012

    • Author(s)
      Ntwasa, M., Goto, A., Kurata, S.
    • Journal Title

      Special Issue on "Antimicrobial Peptides as Therapeutic Agents" International Journal of Microbiology

      Volume: (Article ID 101989) Pages: 1-8

    • DOI

      10.1155/2012/101989

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Innate Immunosuppressive Effect of 1,2-Cyclopentanediol Derivatives2011

    • Author(s)
      Kikuchi, H., Okazaki, K., Sekiya, M., Uryu, Y., Ueda, K., Katou, Y., Kurata, S. Oshima, Y.
    • Journal Title

      Eur. J. Med. Chem.

      Volume: 46 Pages: 1263-1273

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phytoceramide analog stimulates the production of chemokines through CREB activation in human endothelial cells2011

    • Author(s)
      Sekiya, M., Ueda, K., Okazaki, K., Terashima, J., Katou,Y., Kikuchi, H., Kurata, S., Oshima, Y.
    • Journal Title

      Int. Immunopharmacol.

      Volume: 11 Pages: 1497-1503

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses2011

    • Author(s)
      Kikuchi, H., Isobe, M., Sekiya, M., Abe, Y., Hoshikawa, T., Ueda, K., Kurata, S., Katou, Y., Oshima, Y.
    • Journal Title

      Org. Lett.

      Volume: 13 Pages: 4624-4627

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Recognition of Pathogens and Autophagy as an Innate Immune Host Defense2011

    • Author(s)
      Yano, T., Kurata, S.
    • Journal Title

      J. Biochem.

      Volume: 150 Pages: 143-149

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Innate Immunosuppressive Effect of 1,2-Cyclopentanediol Derivatives2011

    • Author(s)
      Kikuchi, H., Okazaki, K., Sekiya, M., Uryu, Y., Ueda, K., Katou, Y., Kurata, S., Oshima, Y
    • Journal Title

      Eur.J.Med.Chem.

      Volume: 46 Pages: 1263-1273

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp.and their promoting activities of innate immune responses2011

    • Author(s)
      Kikuchi, H., Isobe, M., Sekiya, M., Abe, Y.,Hoshikawa, T., Ueda, K., Kurata, S., Katou, Y., Oshima, Y.
    • Journal Title

      Org.Lett.

      Volume: 13 Pages: 4624-4627

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自然免疫機構を利用した感染制御2011

    • Author(s)
      倉田祥一朗、後藤彰
    • Journal Title

      遺伝

      Volume: 65 Pages: 21-26

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Cooperative regulation of the induction of the novel antibacterial listericin by PGRP-LE and the JAK-STAT pathway2010

    • Author(s)
      Goto, A., Yano, T., Terashima, J., Iwashita, S., Oshima, Y. Kurata, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 15731-15738

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC2010

    • Author(s)
      Kurata, S.
    • Journal Title

      Int. Immunol.

      Volume: 22 Pages: 143-148

    • NAID

      10027391539

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative regulation of the induction of the novel antibacterial listericin by PGRP-LE and the JAK-STAT pathway2010

    • Author(s)
      Goto, A., Yano, T., Terashima, J., Iwashita, S., Oshima, Y., Kurata, S.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 15731-15738

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC2010

    • Author(s)
      Kurata, S.
    • Journal Title

      Int.Immunol.

      Volume: 42 Pages: 143-148

    • NAID

      10027391539

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ショウジョウバエ病原体センサーPGRP-LEによる炎症誘導とオートファジー誘導2010

    • Author(s)
      倉田祥一朗
    • Journal Title

      炎症と免疫

      Volume: 18 Pages: 3-7

    • Related Report
      2010 Annual Research Report
  • [Journal Article] An unexpected twist for autophagy in Crohn's desease2009

    • Author(s)
      Yano, T., Kurata, S.
    • Journal Title

      Nature Immunol.

      Volume: 10 Pages: 134-136

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New diterpene pyrone-type compounds, metarhizins A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their inhibitory effects on cellular proliferation2009

    • Author(s)
      Kikuchi, H., Hoshi, T., Kitayama, M., Sekiya, M., Katou, Y., Ueda, K., Kubohara, Y., Sato, H., Shimazu, M., Kurata, S., Oshima, Y.
    • Journal Title

      Tetrahedron

      Volume: 65 Pages: 469-477

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Revised Structure and Synthesis of Celastramycin A, a Potent Innate Immune Suppressor2009

    • Author(s)
      Kikuchi, H., Sekiya, M., Katou, Y., Ueda, K., Kabeya, T., Kurata, S., Oshima, Y.
    • Journal Title

      Organic letters

      Volume: 11 Pages: 1693-1695

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] An unexpected twist for autophagy in Crohn's desease.2009

    • Author(s)
      Yano, T., Kurata, S
    • Journal Title

      Nature Immunology

      Volume: 10 Pages: 134-136

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 昆虫の自然免疫機構を解き明かす2009

    • Author(s)
      倉田祥一朗
    • Journal Title

      化学

      Volume: 64 Pages: 12-17

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ショウジョウバエモデルによる病原細菌認識と排除の分子機構2009

    • Author(s)
      倉田祥一朗
    • Journal Title

      実験医学増刊「感染症のサイエンス」

      Volume: 27 Pages: 212-217

    • Related Report
      2009 Annual Research Report
  • [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity2014

    • Author(s)
      倉田祥一朗
    • Organizer
      Glasgow Epitheliome meeting in April 2014
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2014-04-23
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity2014

    • Author(s)
      倉田祥一朗
    • Organizer
      Asian invertebrate immunity symposium 2013
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2014-02-14
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] Recognition of microbes and regulation of innate immunity2014

    • Author(s)
      Shoichiro Kurata
    • Organizer
      KVA-JSPS Seminar
    • Place of Presentation
      Sweden: Uppsala, Umea Stockholm, and Finland: Tampere
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A receptor-type guanylate cyclase mediates humoral and cellular responses in Drosophila immunity2013

    • Author(s)
      倉田祥一朗
    • Organizer
      EMBO-ESF Research Conference on Integrated Insect Immunology: From Basic Biology To Environmental Applications
    • Place of Presentation
      Pultusk, Poland
    • Year and Date
      2013-09-23
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] A receptor-type guanylate cyclase mediates humoral and cellular responses in Drosophila immunity2013

    • Author(s)
      Shoichiro Kurata
    • Organizer
      EMBO-ESF Research Conference “Integrated Insect Immunology: From Basic Biology To Environmental Applications”
    • Place of Presentation
      Pultusk, Poland.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity2012

    • Author(s)
      倉田祥一朗
    • Organizer
      XXIV International Congress of Entomology
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2012-08-19
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] Plenary lecture. New Toll gate for humoral and cellular immune response in Drosophila2012

    • Author(s)
      倉田祥一朗
    • Organizer
      The 12th Congress of the International Society of Developmental and Comparative Immunology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2012-07-09
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] New Toll gate for humoral and cellular immune response in Drosophila2012

    • Author(s)
      Shoichiro Kurata
    • Organizer
      The 12th Congress of the International Society of Developmental and Comparative Immunology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2012-07-09
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A receptor guanylyl cyclase mediates humoral and cellular responses in Drosophila immunity2011

    • Author(s)
      倉田祥一朗
    • Organizer
      8^<th> International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] A receptor guanylyl cyclase mediates humoral and cellular responses in Drosophila immunity2011

    • Author(s)
      倉田祥一朗
    • Organizer
      8th International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-05-31
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Innate immune responses in Drosophila2010

    • Author(s)
      倉田祥一朗
    • Organizer
      International symposium on Deciphering a link between pathogen sensors and inflammatory diseases
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-07-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Recognition of intracellular bacterial infections and induction of autophagy in Drosophila immunity2010

    • Author(s)
      倉田祥一朗
    • Organizer
      The 2010 Gordon Research Conference on Autophagy in Stress, Development & Disease
    • Place of Presentation
      Lucca (Barga), Italy
    • Year and Date
      2010-04-25
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Intracellular bacterial recognition and induction of immune responses in Drosophila2010

    • Author(s)
      倉田祥一朗
    • Organizer
      The STINT workshop
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2010-03-15
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Recognition of intracellular bacterial infections and induction of autophagy in Drosophila immunity2010

    • Author(s)
      Kurata, S.
    • Organizer
      The 2010 Gordon Research Conference on Autophagy in Stress, Development&Disease
    • Place of Presentation
      Lucca (Barga), Italy(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Induction of autophagy via intracellular innate immune recognition in Drosophila2009

    • Author(s)
      倉田祥一朗
    • Organizer
      5th International Symposium on Autophagy
    • Place of Presentation
      Otsu, Japan
    • Year and Date
      2009-09-24
    • Related Report
      2013 Final Research Report 2009 Annual Research Report
    • Invited
  • [Presentation] Induction of autophagy via intracellular innate immune recognition in Drosophila2009

    • Author(s)
      倉田祥一朗
    • Organizer
      CNRS meeting "Insect immunity in action"
    • Place of Presentation
      Aussois, France
    • Year and Date
      2009-05-23
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Induction of autophagy via intracellular innate immune recognition in Drosophila2009

    • Author(s)
      倉田祥一朗
    • Organizer
      The 66th KABMB annual meeting
    • Place of Presentation
      C0EX, Korea
    • Year and Date
      2009-05-12
    • Related Report
      2013 Final Research Report
    • Invited
  • [Book] Invertebrate Immunity2010

    • Author(s)
      Kenneth Soderhall (Ed.)
    • Publisher
      Landes Bioscience and Springer Science+Business Media
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 生命機能解析学分野

    • URL

      http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 生命機能解析学分野

    • URL

      http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2018-03-28  

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