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Structural analyses of the metastable ligand-receptor interactions

Planned Research

Project AreaIntegrative understanding of biological processes mediated by transient macromolecular complexes; New technology for visualizing physiologically metastable states.
Project/Area Number 21121002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

SHIMADA Ichio  東京大学, 薬学研究科(研究院), 教授 (70196476)

Co-Investigator(Kenkyū-buntansha) JEE Jungoo  首都大学東京, 戦略研究センター, 准教授 (50381554)
KAINOSHO Masatsune  首都大学東京, 戦略研究センター, 客員教授 (20137029)
Co-Investigator(Renkei-kenkyūsha) OSAWA Masanori  東京大学, 大学院薬学系研究科, 講師 (60361606)
UEDA Takumi  東京大学, 大学院薬学系研究科, 助教 (20451859)
NISHIDA Noritaka  東京大学, 大学院薬学系研究科, 助教 (50456183)
KAINOSHO Masatsune  首都大学東京, 戦略研究センター, 教授 (20137029)
Project Period (FY) 2009-07-23 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥346,320,000 (Direct Cost: ¥266,400,000、Indirect Cost: ¥79,920,000)
Fiscal Year 2013: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2012: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2011: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2010: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2009: ¥204,360,000 (Direct Cost: ¥157,200,000、Indirect Cost: ¥47,160,000)
Keywords核磁気共鳴法 / 膜タンパク質 / 相互作用 / 過渡的複合体 / 構造生物学 / 転移交差飽和法 / 構造平衡
Research Abstract

It has been considered that the transient molecular complexes play an important role in many biological processes inside the living cells. In this project, we aimed to establish the NMR methodologies, which can observe the NMR signals from such short lived states, and reconstitute such state by mimicking physiological environments. We applied these methods to the actual biologically important systems, including chemokine-chemokine receptors, the cell adhesion molecule CD44, and the photosynthesis complex, and successfully obtained the structural information of the transiently formed complex of those molecules, which are related to their function.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (146 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (59 results) (of which Peer Reviewed: 54 results,  Acknowledgement Compliant: 1 results) Presentation (81 results) (of which Invited: 13 results) Book (1 results) Remarks (5 results)

  • [Journal Article] Identification of a binding element for the cytoplasmic regulator FROUNTin the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5.2014

    • Author(s)
      Toda E, Terashlma Y, Esakii K, Yoshinaga S, Sugihara M, Kofuku Y, Shimada I, Suwa M, Kanegasaki S, Terasawa H, Matsushima K.
    • Journal Title

      Biochemical Journal

      Volume: Vol.457 Issue: 2 Pages: 313-322

    • DOI

      10.1042/bj20130827

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand.2014

    • Author(s)
      Ono K, Takeuchi K, Ueda H, Morita Y, Tanimura R, Shimada I, Takahashi H.
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 53 Issue: 10 Pages: 2597-2597

    • DOI

      10.1002/anie.201310749

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional dynamics of cell surface membrane proteins2014

    • Author(s)
      Nishida N, Osawa M, Takeuchi K, Imai S, Stampoulis P, Kofuku Y, Ueda T, Shimada I
    • Journal Title

      J Magn Reson

      Volume: 241 Pages: 86-96

    • DOI

      10.1016/j.jmr.2013.11.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Gel-Encapsulated Bioreactor System for NMR Studies of Protein-Protein Interactions in Living Mammalian Cells2013

    • Author(s)
      Satoshi Kubo, Noritaka Nishida, Yuko Udagawa, Osamu Takarada, Shinji Ogino, Ichio Shimada
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 52 Issue: 4 Pages: 1208-1211

    • DOI

      10.1002/anie.201207243

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for the cytoplasmic region of the Mg(2+) transporter MgtE in the Mg (2+)-unbound state2013

    • Author(s)
      Maruyama T, Imai S, Osawa M, Hattori M, Ishitani R, Nureki O, Shimada I.
    • Journal Title

      Biomol NMR Assign

      Volume: 7 Issue: 1 Pages: 93-96

    • DOI

      10.1007/s12104-012-9385-y

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the Mouse Sex Peptide Pheromone ESP1 Reveals a Molecular Basis for Specific Binding to the Class C G-protein-coupled Vomeronasal Receptor2013

    • Author(s)
      Yoshinaga S, Sato T, Hirakane M, Esaki K, Hamaguchi T, Haga-Yamanaka S, Tsunoda M, Kimoto H, Shimada I, Touhara K, Terasawa H
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Issue: 22 Pages: 16064-72

    • DOI

      10.1074/jbc.m112.436782

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for G protein α(i3) subunit in the GDP-bound state2013

    • Author(s)
      Mase Y, Yokogawa M, Osawa M, Shimada I.
    • Journal Title

      Biomol NMR Assign

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear magnetic resonance approaches for characterizing interactions between the bacterial chaperonin GroEL and unstructured proteins.2013

    • Author(s)
      Nishida N, Yagi-Utsumi M, Motojima F, Yoshida M, Shimada I, Kato K.
    • Journal Title

      J Biosci Bioeng

      Volume: 116 Issue: 2 Pages: 160-164

    • DOI

      10.1016/j.jbiosc.2013.02.012

    • NAID

      110009657195

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perdeuteration and methyl-selective (1)H, (13)C-labeling by using a Kluyveromyces lactis expression system2013

    • Author(s)
      Miyazawa-Onami M, Takeuchi K, Takano T, Sugiki T, Shimada I, Takahashi H.
    • Journal Title

      J Biomol NMR

      Volume: 57 Issue: 3 Pages: 297-304

    • DOI

      10.1007/s10858-013-9789-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid identification of ligand-binding sites by using an assignment-free NMR approach2013

    • Author(s)
      Kodama Y, Takeuchi K, Shimba N, Ishikawa K, Suzuki E, Shimada I, Takahashi H.
    • Journal Title

      J Med Chem

      Volume: 56 Issue: 22 Pages: 9342-9350

    • DOI

      10.1021/jm4014357

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the modulation of the gating property of G protein-gated inwardly rectifying potassium ion channel (GIRK)by the i/o-family G protein α subunit (Gdi_<i/o>)2012

    • Author(s)
      間瀬瑶子
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287 Issue: 23 Pages: 19537-19549

    • DOI

      10.1074/jbc.m112.353888

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region2012

    • Author(s)
      Kofuku Y, Ueda T, Okude J, Shiraishi Y, Kondo K, Maeda M, Tsujishita H, Shimada I
    • Journal Title

      Nat Commun.

      Volume: 3 Issue: 1 Pages: 1045-1045

    • DOI

      10.1038/ncomms2046

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis of Efficient Electron Transport between Photosyn thetic Membrane Proteins and Plastocyanin in Spinach Revealed using Nuclear Magnetic Resonance2012

    • Author(s)
      Takumi Ueda, Naoko Nomoto, Masamichi Koga, Hiroki Ogasa, Yuuta Ogawa, Masahiko Matsumoto, Pavlos Stampoulis, Koji Sode, Hiroaki Terasawa and Ichio Shimada
    • Journal Title

      Plant Cell

      Volume: 24 Issue: 10 Pages: 4173-4186

    • DOI

      10.1105/tpc.112.102517

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Segmental isotopic labeling of a 140 kDa dimeric multi-domain protein CheA from Escherichia coli by expressed protein ligation and protein trans-splicing2012

    • Author(s)
      Minato Y, Ueda T, Machiyama A, Shimada l, Iwai H
    • Journal Title

      Journal of Biomolecular NMR

      Volume: 53 Issue: 3 Pages: 191-207

    • DOI

      10.1007/s10858-012-9628-3

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An NMR method to study protein-protein interactions2012

    • Author(s)
      Nishida N, Shimada I.
    • Journal Title

      Methods Mol Biol

      Volume: 757 Pages: 129-137

    • DOI

      10.1007/978-1-61779-166-6_10

    • ISBN
      9781617791659, 9781617791666
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isotopic labeling of heterologous proteins in the yeast Pichia pastoris and Kluyveromyces lactis2012

    • Author(s)
      Sugiki T, Ichikawa O, Miyazawa-Onami M, Shimada I, Takahashi H.
    • Journal Title

      Methods Mol Biol

      Volume: 831 Pages: 19-36

    • DOI

      10.1007/978-1-61779-480-3_2

    • ISBN
      9781617794797, 9781617794803
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical membrane-embedded p47^<phox> PI(3,4)P_2 binding site on PX domain revealed by NMR2012

    • Author(s)
      Stampoulis P, Ueda T, Matsumoto M, Terasawa H, Miyano K, Sumimoto H, and Shimada I
    • Journal Title

      J. Biol. Chem

      Volume: 287 Issue: 21 Pages: 17848-17859

    • DOI

      10.1074/jbc.m111.332874

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes2012

    • Author(s)
      Onizuka T, Shimizu H, Moriwaki Y, Nakano T, Kanai S, Shimada I, Takahashi H.
    • Journal Title

      FEBS J

      Volume: 279 Issue: 15 Pages: 2645-2656

    • DOI

      10.1111/j.1742-4658.2012.08643.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)2012

    • Author(s)
      Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, Shimada I.
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 33706-33718

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional dynamics of proteins revealed by solution NMR2012

    • Author(s)
      Osawa M, Takeuchi K, Ueda T, Nishida N, Shimada I.
    • Journal Title

      Curr Opin Struct Biol

      Volume: 22 Issue: 5 Pages: 660-669

    • DOI

      10.1016/j.sbi.2012.08.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for G protein α(i3) subunit in the GTP-bound state2012

    • Author(s)
      Mase Y, Yokogawa M, Osawa M, Shimada I.
    • Journal Title

      Biomol NMR Assign

      Volume: 6 Issue: 2 Pages: 217-220

    • DOI

      10.1007/s12104-012-9361-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial distribution of cytoplasmic domains of the Mg(2+)-transporter MgtE, in a solution lacking Mg(2+), revealed by paramagnetic relaxation enhancement2012

    • Author(s)
      Imai S, Maruyama T, Osawa M, Hattori M, Ishitani R, Nureki O, Shimada I.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1824 Issue: 10 Pages: 1129-1135

    • DOI

      10.1016/j.bbapap.2012.06.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay.2012

    • Author(s)
      Osawa M, Hosoda N, Nakanishi T, Uchida N, Kimura T, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I.
    • Journal Title

      RNA

      Volume: 18 Issue: 11 Pages: 1957-1967

    • DOI

      10.1261/rna.035311.112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional equilibrium of the KcsA structure revealed by NMR2012

    • Author(s)
      Imai S, Osawa M, Mita K, Toyonaga S, Machiyama A, Ueda T, Takeuchi K, Oiki S, Shimada I.
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 47 Pages: 39634-39641

    • DOI

      10.1074/jbc.m112.401265

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An NMR method to study prolein-protcin interaction2012

    • Author(s)
      Noritaka Nishida, Ichio Shimadn
    • Journal Title

      Methods Mol. Biol.

      Volume: 757 Pages: 129-37

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolopic labeling of heterologous proteins in the yeast Pichia pastoris and Kluyvcromyccs lactis2012

    • Author(s)
      Toshihiko Sugiki, Osamu Ichikawa, Mayumi Miyazawa,-Onami, Ichio Shimada, Hideo Takaliashi
    • Journal Title

      Methods Mol. Biol. (2012) 831, 19-36.,

      Volume: 831 Pages: 19-36

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Identification of Protein-Protein Interfaces and Construction of Complex Model Based on Multiple Unassigned Signals By Using Time-sharing NMR Measurement2011

    • Author(s)
      Yuya Kodama, Michael L, Reese, Nobuhisa Shimba, Volker Dotsch, Ei-ichiro Suzuki, Ichio Shimada, Hideo Takahashi
    • Journal Title

      J. Struct. Biol.

      Volume: 174 Pages: 434-42

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Affinity transfer to human protein by CDR3 grafting of camelid VHH2011

    • Author(s)
      Hidetoshi Inoue, Akiko Ilhara, Hideo Takahashi, Ichio Shimada, Isao Ishidal, Yoshitake Maeda
    • Journal Title

      Protein Sci.

      Volume: 20 Pages: 1971-81

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR2011

    • Author(s)
      Yoshifumi Fukunishi, Yumiko Mizukoshi, Koh Takeuchi, Ichio Shimada, Hideo Takahashi, Haruki Nakamura
    • Journal Title

      J. Mol. Graph. Model.

      Volume: 31 Pages: 20-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Accurate Pharmacophore Mapping Method by NMR2011

    • Author(s)
      Yumiko Mizukoshi, Aya Abe, Takeshi Takizawa, Hiroyuki Hanzawa, Yoshifumi Fukunishi, Ichio Shimada, Hideo Taknhashi
    • Journal Title

      Angew. Chem. In Ed Engl. (2011)

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure determination of a protein assembly by amino acid selective cross-saturation2011

    • Author(s)
      Eiji Kanamori, Shunsuke Igarashi, Masanori Osawa, Yoshifumi Fukunishi, Ichio Shimada, Haruki Nakamura
    • Journal Title

      Proteins

      Volume: 79 Pages: 179-190

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling : a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment2011

    • Author(s)
      Koh Takeuchi, Maayan Gal, Hideo Takahashi, Ichio Shimada, Gerhard Wagner
    • Journal Title

      J.Biomol.NMR

      Volume: 49 Pages: 17-26

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis underlying the dual gate properties of KcsA2010

    • Author(s)
      Imai S, Osawa M, Takeuchi K, Shimada I
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107(14) Issue: 14 Pages: 6216-21

    • DOI

      10.1073/pnas.0911270107

    • Related Report
      2013 Final Research Report
  • [Journal Article] NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers2010

    • Author(s)
      Yoshiura C, Kofuku Y, Ueda T, Mase Y, Yokogawa M, Osawa M, Terashima Y, Matsushima K, Shimada I
    • Journal Title

      J Am Chem Soc.

      Volume: 132(19) Issue: 19 Pages: 6768-77

    • DOI

      10.1021/ja100830f

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical analyses of the transferred cross-saturation method, Epub 20102010

    • Author(s)
      Matsumoto M, Ueda T, Shimada I
    • Journal Title

      J Magn Reson.

      Volume: 205(1) Issue: 1 Pages: 114-24

    • DOI

      10.1016/j.jmr.2010.04.011

    • Related Report
      2013 Final Research Report
  • [Journal Article] Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition2010

    • Author(s)
      Ogino S, Nishida N, Umemoto R, Suzuki M, Takeda M, Terasawa H, Kitayama J, Matsumoto M, Hayasaka H, Miyasaka M, Shimada I
    • Journal Title

      Structure.

      Volume: 18(5) Issue: 5 Pages: 649-56

    • DOI

      10.1016/j.str.2010.02.010

    • Related Report
      2013 Final Research Report
  • [Journal Article] Production of isotopically labeled heterologous proteins in non-E.coli prokaryotic and eukaryotic cells2010

    • Author(s)
      Hideo Takahashi, Ichio Shimada
    • Journal Title

      J.Biomol.NMR

      Volume: 46 Pages: 3-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time assay method of lipid extraction activity2010

    • Author(s)
      Toshihiko Sugiki, Hideo Takahashi, Michiko Nagasu, Kentaro Hanada, Ichio Shimada
    • Journal Title

      Anal.Biochem.

      Volume: 399 Pages: 162-167

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis for Platelet Anti-aggregation by AT1-Receptor Antagonist Losartan via Glycoprotein VI2010

    • Author(s)
      Katsuki Ono, Hiroshi Ueda, Yoshitaka Yoshizawa, Daisuke Akazawa, Ryuji Tanimura, Ichio Shimada, Hideo Takahashi
    • Journal Title

      J.Med.Chem.

      Volume: 53 Pages: 1917-1922

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct determination of the insulin-insulin receptor interface using transferred cross-saturation experiments2010

    • Author(s)
      Takefumi Nakamura, Hideo Takahashi, Mitsuo Takahashi, Nobuhisa Shimba, Ei-ichiro Suzuki, Ichio Shimada
    • Journal Title

      J.Med.Chem.

      Volume: 53 Pages: 2087-2093

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis underlying the dual gate properties of KcsA2010

    • Author(s)
      Shunsuke Imai, Masanori Osawa, Koh Takeuchi, Ichio Shimada
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 107 Pages: 6216-6221

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-state conformational equilibrium of the hyaluronan-binding domain regulates adhesiveness of CD44 under flow condition2010

    • Author(s)
      Shinji Ogino, Noritaka Nishida, Ryo Umemoto, Miho Suzuki, Mitsuhiro Takeda, Hiroaki Terasawa, Joji Kitayama, Masanori Matsumoto, Haruko Hayasaka, Masayuki Miyasaka, Ichio Shimada
    • Journal Title

      Structure

      Volume: 18 Pages: 649-656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precise structural determination of weakly binding peptides by utilizing dihedral angle constraints2010

    • Author(s)
      Yumiko Mizukoshi, Michiko Nagasu, Ichio Shimada, Hideo Takahashi
    • Journal Title

      J.Biomol.NMR

      Volume: 46 Pages: 299-305

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers2010

    • Author(s)
      Chie Yoshiura, Yutaka Kofuku, Takumi Ueda, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Yuya Terashima, Kouji Matsushima, Ichio Shimada
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 132 Pages: 6768-6777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical analyses of the transferred cross-saturation method2010

    • Author(s)
      Masahiko Matsumoto, Takumi Ueda, Ichio Shimada
    • Journal Title

      J.Magn.Reson.

      Volume: 205 Pages: 114-124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for the ligand binding subunit of the histidine permease complex (HisJ) from Escherichia coli, under histidine-bound and unbound states.2010

    • Author(s)
      Igarashi S, Osawa M, Ozawa S, Shimada I.
    • Journal Title

      Biomol NMR Assign.

      Volume: 4 Pages: 7-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode2010

    • Author(s)
      Ryo Umemotoa, Noritaka Nishida, Shinji Oginoa, Ichio Shimada
    • Journal Title

      J.Biomol.NMR

      Volume: 48 Pages: 59-64

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative characterization of the Tob interactions provides the thermodynamic basis on the translation termination-coupled deadenylase regulation2010

    • Author(s)
      Lin Ruan, Masanori Osawa, Nao Hosoda, Shunsuke Imai, Asako Machiyama, Toshiaki Katada, Shin-ichi Hoshino, Ichio Shimada
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 27624-27631

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of NMR signals from proteins introduced into living mammalian cells by reversible membrane permeabilization using a pore-forming toxin, Streptolysin O2009

    • Author(s)
      Ogino S, Kubo S, Umemoto R, Huang S, Nishida N, Shimada I
    • Journal Title

      J Am Chem Soc.

      Volume: 131(31) Issue: 31 Pages: 10834-5

    • DOI

      10.1021/ja904407w

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR42009

    • Author(s)
      Kofuku Y, Yoshiura C, Ueda T, Terasawa H, Hirai T, Tominaga S, Hirose M, Maeda Y, Takahashi H, Terashima Y, Matsushima K, Shimada I
    • Journal Title

      J Biol Chem.

      Volume: 284(50) Issue: 50 Pages: 35240-50

    • DOI

      10.1074/jbc.m109.024851

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cross-saturation and transferred cross-saturation experiments2009

    • Author(s)
      Ichio Shimada, el al
    • Journal Title

      Prog.Nuc.Magn.Reson.Spect.

      Volume: 54 Pages: 123-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A High-throughput Screening of Optimal Solution Conditions for Structural Biological Studies with Fluorescence Correlation Spectroscopy2009

    • Author(s)
      Toshihiko Sugiki, et al
    • Journal Title

      Protein Sci.

      Volume: 18 Pages: 1115-20

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural and Interaction analysis of glycoprotein VI-binding peptide selected from phage display library.2009

    • Author(s)
      Kozue Kato-Takagaki, et al
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Pages: 10720-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1(GIRK1)2009

    • Author(s)
      Mariko Yakogawa, et al
    • Journal Title

      Biomolecular NMR Assignments

      Volume: 3 Pages: 125-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An NMR Method for the Determination of Protein Binding Interfaces using TEMPOL-Induced Chemical Shift Perturbations2009

    • Author(s)
      Jun Moriya, et al
    • Journal Title

      Biochim.Biophys.Acta

      Volume: 90 Pages: 1368-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural investigation of the interaction between the periplasmic chaperone LolA and the outer membrane receptor LolB using NMR2009

    • Author(s)
      Shingo Nakada, et al
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Pages: 24634-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of NMR signals from proteins introduced into living mammalian cells by reversible membrane permeabilization using a pore-forming toxin, Streptolysin 02009

    • Author(s)
      Shinji Ogino, et al
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 131 Pages: 10834-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for the direct interaction of spermine with inwardly rectifying potassium channel2009

    • Author(s)
      Masanori Osawa, et al
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Pages: 26117-126

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between chemokine SDF-1 and its GPCR CXCR4 investigated by NMR2009

    • Author(s)
      Yutaka kofuku, et al
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Pages: 35240-50

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 二次元NMRインターフェログラム再構成法の開発およびCCR5のMIP-1α結合様式の解明への応用2014

    • Author(s)
      上田卓見、吉浦知絵、松本昌彦、幸福裕、奥出順也、近藤啓太、白石勇太郎、嶋田一夫
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] β2-アドレナリン受容体のシグナル制御機構の解明2014

    • Author(s)
      幸福 裕,上田 卓見,奥出 順也,白石 勇太郎,近藤 啓太,前田 正洋,
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] NMR 法による脂質二重膜中における P2X4受容体の動的構造平衡の解明2014

    • Author(s)
      鈴木 志歩,湊 雄一,幸福 裕,上田 卓見,服部 素之,濡木 理,嶋田 一夫
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] β2 アドレナリン受容体のリン酸化によるシグナル制御機構の解明2014

    • Author(s)
      白石 勇太郎,幸福 裕,上田 卓見,嶋田 一夫
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂質二重膜中の脂質による GPCR の活性制御機構の解明2014

    • Author(s)
      水村 拓也、近藤 啓太、幸福 裕、上田 卓見、嶋田 一夫
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] NMR 法による P2X4 受容体の開閉制御機構の解明2014

    • Author(s)
      湊 雄一、鈴木 志歩,幸福 裕,上田 卓見,服部 素之,濡木 理,嶋田 一夫
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電位依存性カリウムイオンチャネルの膜電位感受機構の解明2014

    • Author(s)
      野﨑智裕, 小澤新一郎, 原田瞳, 木村友美, 大澤匡範, 嶋田一夫
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] NMRを用いた高分子量タンパク質複合体の相互作用解析法の開発と応用2013

    • Author(s)
      嶋田一夫
    • Organizer
      ワークショップ「原理まで遡って再確認する核磁気共鳴法の実力」第36回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional Equilibrium of GPCR2013

    • Author(s)
      嶋田一夫
    • Organizer
      5th Asia-Pacific NMR Symposium in conjunction with ANZNAG2013
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2013-10-24
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Functional Equilibrium of GPCR2013

    • Author(s)
      嶋田一夫
    • Organizer
      Symposium "Perspectives of NMR in drug discovery"
    • Place of Presentation
      Novartis, Basel, Switzerland
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional Equilibrium of Membrane Proteins2013

    • Author(s)
      嶋田一夫
    • Organizer
      International Conference on Structural Genomics 2013
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2013-07-24
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Functional Equilibrium of Membrane Proteins2013

    • Author(s)
      嶋田一夫
    • Organizer
      54th Experimental Nuclear Magnetic Resonance Conference
    • Place of Presentation
      Asilomar, California, USA
    • Year and Date
      2013-04-15
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] NMRによる膜タンパク質の機能解明2013

    • Author(s)
      嶋田一夫
    • Organizer
      よこはまNMR構造生物学研究会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Functional Equilibrium of Membrane Proteins2013

    • Author(s)
      嶋田一夫
    • Organizer
      Frontiers of NMR in Biology, Keystone Symposia
    • Place of Presentation
      Snowbird, Utah, USA
    • Year and Date
      2013-01-17
    • Related Report
      2013 Final Research Report
  • [Presentation] A gel-encapsulated bioreactor system for NMR studies of protein-protein interactions in living mammalian cells.2013

    • Author(s)
      西田紀貴、嶋田一夫
    • Organizer
      生物物理学会 第51回年会
    • Place of Presentation
      京都府京都市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Affinity regulation mechanism of microtubule-binding domain of cytoplasmic dynein2013

    • Author(s)
      西田紀貴、宝田理、吉川雅英、嶋田一夫
    • Organizer
      Dynein2013
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] イオンチャネルの機能に関連した動的構造2013

    • Author(s)
      今井駿輔、○大澤匡範、三田建一郎、豊永翔、町山麻子、上田卓見、竹内 恒、老木成稔、嶋田一夫
    • Organizer
      第35回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      東京都文京区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMR observation of protein-protein interactions in living mammalian cells using a gel encapsulated bioreactor system2013

    • Author(s)
      西田紀貴、嶋田一夫
    • Organizer
      第36回分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Elucidation of the transient interaction between ubiquitin and yeast ubiquitin hydrolase by NMR2013

    • Author(s)
      小笠 広起、上田 卓見、松本 昌彦、嶋田 一夫
    • Organizer
      Nagoya Symposium - Frontiers in Structural Physiology
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Efficacy of the b2-adrenergic receptor is determined by conformational2013

    • Author(s)
      幸福 裕、上田 卓見、奥出 順也、白石 勇太郎、近藤 啓太、前田 正洋、辻下 英樹、嶋田 一夫
    • Organizer
      Nagoya Symposium - Frontiers in Structural Physiology
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Alternate Signal Transduction Mechanism of CheA and CheY revealed by NMR2013

    • Author(s)
      湊 雄一、上田 卓見、町山 麻子、岩井 秀夫、嶋田 一夫
    • Organizer
      Nagoya Symposium - Frontiers in Structural Physiology
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structurral elucidation of the Mg2+-dependent gating mechanism of a Mg2+ transporter MgtE2013

    • Author(s)
      丸山達朗, 今井駿輔, 大澤匡範, 服部素之, 石谷隆一郎, 濡木理, 嶋田一夫
    • Organizer
      Nagoya Symposium - Frontiers in Structural Physiology
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structural Basis for Regulation of G Protein Regulation of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) by G Protein2013

    • Author(s)
      大澤匡範、間瀬瑤子、横川真梨子、竹内恒、嶋田一夫
    • Organizer
      Nagoya Symposium - Frontiers in Structural Physiology
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] バイオリアクターを用いた in-cell NMR 法による細胞内タンパク質間相互作用の観測2013

    • Author(s)
      西田紀貴、久保智史、嶋田一夫
    • Organizer
      日本薬学会 第133回年会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional Dynamics of Membrane Proteins by NMR2012

    • Author(s)
      嶋田一夫
    • Organizer
      第85回生化学会年会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] NMRによる膜タンパク質の機能解明2012

    • Author(s)
      嶋田一夫
    • Organizer
      第34回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      京都大学薬学部京都市
    • Year and Date
      2012-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional Equilibrium of Membrane Proteins2012

    • Author(s)
      嶋田一夫
    • Organizer
      The 3rd International Symposium on Drug Discovery and Design by NMR
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2012-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional Dynamics of Membrane Proteins2012

    • Author(s)
      嶋田一夫
    • Organizer
      ICMRBS
    • Place of Presentation
      Lyon, France
    • Year and Date
      2012-08-21
    • Related Report
      2013 Final Research Report
  • [Presentation] NMRを用いた膜タンパク質の機能解明2012

    • Author(s)
      嶋田一夫
    • Organizer
      第11回日本蛋白質科学会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2012-06-22
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2012

    • Author(s)
      嶋田一夫
    • Organizer
      INPEC2012
    • Place of Presentation
      台北、台湾
    • Year and Date
      2012-04-06
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] A novel in-cell NMR technique to determine the binding interface of functional protein complexes in mammalian cells2012

    • Author(s)
      久保智史*、荻野新治、宇田川侑子*、宝田理#、西田紀貴、嶋田一夫
    • Organizer
      第132回日本薬学会 年会 日本薬学会
    • Place of Presentation
      北海逆大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] The effect of tensile force on CD44 mediated cell rolling2012

    • Author(s)
      鈴木隆*、鈴木美穂#、西田紀貴、嶋田一夫
    • Organizer
      第132回日本薬学会 年会 日本薬学会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elucidation of regulatory mechanism for arrestin activation by G-protein coupled receptor (ポスター)2012

    • Author(s)
      白石勇太郎*, 幸福裕, 奥出順也*, 吉浦知絵, 阿内康平*, 上田卓見, 嶋田一夫
    • Organizer
      第132回日本薬学会 年会 日本薬学会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elucidation of the mechanism of analgesic tolerance by chronic administration of morphine2012

    • Author(s)
      奥出順也*, 吉浦知絵, 白石勇太郎*, 幸福裕, 上田卓見, 嶋田一夫
    • Organizer
      第132回日本薬学会 年会 日本薬学会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内向き整流性カリウムチャネル開閉機構の解明2012

    • Author(s)
      外山侑樹、大澤匡範、横川真梨子、豊永翔、町山麻子、嶋田一夫
    • Organizer
      第12回日本蛋白質科学会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Elucidation of the transient interaction between ubiquitin and yeast ubiquitin hydrolase2012

    • Author(s)
      小笠 広起、上田 卓見、松本 昌彦、嶋田 一夫
    • Organizer
      25th ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Protein-protein docking method utilizing the intermolecular 1H-1H distance restraints obtained by the quantitative cross-saturation method2012

    • Author(s)
      松本 昌彦、上田 真也、上田 卓見、嶋田 一夫
    • Organizer
      25th ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structural Elucidation of the Alternate Signal Transduction Mechanism of CheA and CheY2012

    • Author(s)
      湊 雄一、上田 卓見、町山 麻子、岩井 秀夫、嶋田 一夫
    • Organizer
      25th ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structural basis for the modulation of the gating property of G protein-gated inwardly rectifying potassium ion channel (GIRK) by G protein α subunit in the i/o-family (Gαi/o)2012

    • Author(s)
      間瀬瑤子、横川真梨子、大澤匡範、嶋田一夫
    • Organizer
      25th ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Elucidation of the Mg2+-dependent gating mechanism of a Mg2+ transporter MgtE2012

    • Author(s)
      丸山達朗, 今井駿輔, 大澤匡範, 服部素之, 石谷隆一郎, 濡木理, 嶋田一夫
    • Organizer
      25th ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Elucidation of the affinity switching mechanism of the microtubule-binding domain of cytoplasmic dynein2012

    • Author(s)
      宝田理、西田紀貴、吉川雅英、嶋田一夫
    • Organizer
      25th ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
  • [Presentation] An NMR method to observe protein-protein interactions in living mammalian cells using the gel encapsulated bioreactor system2012

    • Author(s)
      久保智史, 西田紀貴, 宇田川侑子, 宝田理, 荻野新治, 嶋田一夫
    • Organizer
      25th ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gタンパク質共役型受容体の動的平衡の制御機構の解明2012

    • Author(s)
      近藤 啓太、幸福 裕、上田 卓見、嶋田 一夫
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ATP effect on Mg2+-dependent gating of a Mg2+ channel MgtE2012

    • Author(s)
      丸山達朗, 今井駿輔, 大澤匡範, 服部素之, 石谷隆一郎, 濡木理, 嶋田一夫
    • Organizer
      第85回生化学会大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞内molecular crowding環境におけるタンパク質間相互作用解析2012

    • Author(s)
      宇田川侑子、久保智史、西田紀貴、嶋田一夫
    • Organizer
      第85回生化学会大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dynamical Aspects of Membrane Proteins2011

    • Author(s)
      Ichio Shimada
    • Organizer
      MBSJ2011
    • Place of Presentation
      パシフィコ横浜(横浜)(招待講演)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural Mechanism for the Affinity-Regulation of Cytoplasmic Dynein2011

    • Author(s)
      宝田理#, 西田紀貴、吉川雅英、嶋田一夫
    • Organizer
      第34回日本分子生物学会年会 日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)(招待講演)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural investigation of voltage-sensing mechanism of voltage-dependent K+ channels (ポスター)2011

    • Author(s)
      原田瞳#, 大澤匡範, 小澤新一郎#, 木村友美, 野崎智裕*, 嶋田一夫
    • Organizer
      第34回日本分子生物学会年会 日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural basis for the inhibition of voltage-dependent potassium (Kv) channels by gating modifier toxins (ポスター)2011

    • Author(s)
      小澤新一郎#、大澤匡範、木村友美、原田瞳#、野崎智裕*、嶋田一夫
    • Organizer
      第34回日本分子生物学会年会 日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dynamical Aspects of Membrane Proteins2011

    • Author(s)
      Ichio Shimada
    • Organizer
      AIMECS11
    • Place of Presentation
      京王プラザホテル(東京)(招待講演)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dynamical Aspects of Membrane Proteins2011

    • Author(s)
      Ichio Shimada
    • Organizer
      The 4th Asia-Pacific NMR Symposium
    • Place of Presentation
      Central Garden Beijing Hotel (北京、中国)(招待講演)
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional Analyses of Membrane Proteins by NMR2011

    • Author(s)
      Ichio Shimada
    • Organizer
      The 9th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] NMR法によるactinとactin結合タンパク質との相互作用解析法の開発2010

    • Author(s)
      黄淑嫻、梅本良、上田太郎、西田紀貴、嶋田一夫
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド,兵庫県
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高分子量蛋白質の構造解析に適した安定同位体ラベル法および測定法の開発2010

    • Author(s)
      竹内恒、高橋栄夫、嶋田一夫、Gerhard Wagner
    • Organizer
      第49回NMR討論会
    • Place of Presentation
      船堀タワーホール,東京都
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      Max Planck Institute seminar
    • Place of Presentation
      Gottingen, Germany
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      Technische Universitat Munchen/Helmholtz Zentrum Munchen seminar
    • Place of Presentation
      Munchen, Germany
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins by NMR2010

    • Author(s)
      嶋田一夫
    • Organizer
      The International Network of Protein Engineering Centres (INPEC) 2010
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] The 2nd International Symposium on Drug Discovery and Design by NMR2010

    • Author(s)
      嶋田一夫
    • Organizer
      Functional analyses of membrane proteins by NMR
    • Place of Presentation
      横浜市立大学,神奈川県
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRを用いた膜タンパク質の機能解明2010

    • Author(s)
      嶋田一夫
    • Organizer
      日本分光学会NMR分光部会シンポジウム
    • Place of Presentation
      東京大学,東京都
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      Frankfurt University seminar
    • Place of Presentation
      Frankfurt, Germany
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamical aspects of membrane proteins2010

    • Author(s)
      嶋田一夫
    • Organizer
      International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRによるケモカイン受容体・ケモカイン相互作用解析2010

    • Author(s)
      嶋田一夫
    • Organizer
      第34回阿蘇シンポジウム
    • Place of Presentation
      阿蘇リゾートグランヴィリオホテル,熊本県
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] -超高磁場が拓く生体系NMR:最新技術と応用-膜タンパク質のダイナミックスと機能2010

    • Author(s)
      嶋田一夫
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学,大阪府
    • Year and Date
      2010-07-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRによる膜タンパク質の機能解析2010

    • Author(s)
      嶋田一夫
    • Organizer
      日本学術振興会、回折構造生物学第169委員会、第32回研究会
    • Place of Presentation
      ゆうぽうと,東京都
    • Year and Date
      2010-07-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural bases of the interactions between chemokines and their G-protein-coupled receptors2010

    • Author(s)
      嶋田一夫
    • Organizer
      Symposium on Structure and Folding of Disease Related Proteins
    • Place of Presentation
      Seoul National University, Korea
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural bases of the interactions between chemokines and their G-protein-coupled receptors2010

    • Author(s)
      嶋田一夫
    • Organizer
      EUROMAR/ISMAR
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 過渡的複合体が関わる生命現象の統合的理解2010

    • Author(s)
      嶋田一夫
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター,北海道
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional analyses of membrane proteins by NMR2010

    • Author(s)
      嶋田一夫
    • Organizer
      COLD SPRING HARBOR ASIA CONFERENCES
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRによる膜タンパク質の機能解明2010

    • Author(s)
      嶋田一夫
    • Organizer
      構造と機能を基盤とした膜蛋白質研究から覗く未来への展望
    • Place of Presentation
      サントリー研究センター・大阪
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 創薬研究と構造生物学2010

    • Author(s)
      嶋田一夫
    • Organizer
      EMP
    • Place of Presentation
      東京大学・東京
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] NMR studies of the interactions between membrane proteins and their ligands2009

    • Author(s)
      嶋田一夫
    • Organizer
      Structural biology seminar
    • Place of Presentation
      Vanderbilt University, USA
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protein recognition by NMR2009

    • Author(s)
      嶋田一夫
    • Organizer
      INPEC2009
    • Place of Presentation
      Itamambuca, Brasil
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] NMRによるリガンド・受容体相互作用解析2009

    • Author(s)
      嶋田一夫
    • Organizer
      第一回シグナルネットワーク研究会
    • Place of Presentation
      東京大学・東京
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional Equilibrium of GPCR

    • Author(s)
      嶋田一夫
    • Organizer
      Symposium “Perspectives of NMR in drug discovery
    • Place of Presentation
      Novartis, Basel, Switzerland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMR を用いた高分子量タンパク質複合体の相互作用解析法の開発と応用

    • Author(s)
      嶋田一夫
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMRによる膜タンパク質の機能解明

    • Author(s)
      嶋田一夫
    • Organizer
      第13回若手NMR研究会
    • Place of Presentation
      北海道、支笏湖
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 膜タンパク質を対象としたNMR創薬基盤技術

    • Author(s)
      嶋田一夫
    • Organizer
      第25回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      東京都港区
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional Dynamics of Membrane Proteins

    • Author(s)
      嶋田一夫
    • Organizer
      ICMRBS
    • Place of Presentation
      リヨン、フランス
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional Dynamics of Membrane Proteins

    • Author(s)
      嶋田一夫
    • Organizer
      The 3rd International Symposium on Drug Discovery and Design by NM
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMRによる膜タンパク質の機能解明

    • Author(s)
      嶋田一夫
    • Organizer
      第34回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      京都府京都市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional Equilibrium of Membrane Proteins

    • Author(s)
      嶋田一夫
    • Organizer
      Frontiers of NMR in Biology, Keystone Symposia,
    • Place of Presentation
      Snowbird, Utah, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Encyclopedia of Biophysics, GCR. Roberts (ed.)2011

    • Author(s)
      Ichio Shimada
    • Total Pages
      1
    • Publisher
      Springer-Verlag Berlin Heidelberg Ichio Sliimada
    • Related Report
      2011 Annual Research Report
  • [Remarks] 過渡的複合体 HP

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京大学大学院薬学系研究科 生命物理化学教室

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/index_j.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科 生命物理化学教室

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/index_j.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/index.html#

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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