|Budget Amount *help
¥112,450,000 (Direct Cost: ¥86,500,000、Indirect Cost: ¥25,950,000)
Fiscal Year 2013: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2012: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2011: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2010: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Protein is one of the central biomolecules that is involved in almost all biological events and thus its quantitative analysis has been actively conducted for many years. Recently, it is now regarded that protein analysis in natural habitats (living systems is ideal) should be crucial, in addition to the analysis in the purified test tube systems. In this research project, we successfully developed several original methods (or synthetic small molecules) based on chemistry that allow for selective labeling and imaging target proteins under nearly natural conditions. These methods may contribute to analyzing protein structure and functions in living cells.