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Swarm intelligence of new neurons: understanding behaviors for efficient regeneration

Planned Research

Project AreaHeterogeneous swarm intelligence: Innovative design of swarm intelligence inspired by collective behavior of variety of cells
Project/Area Number 21H05106
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (II)
Research InstitutionDoshisha University (2022-2023)
Nagoya City University (2021)

Principal Investigator

Kaneko Naoko  同志社大学, 脳科学研究科, 教授 (20464571)

Project Period (FY) 2021-08-23 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000)
Fiscal Year 2023: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2022: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2021: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Keywords脳室下帯 / 細胞移動 / アストロサイト / 数理モデル / 神経再生 / 群知能 / ニューロン再生 / 脳梗塞 / 新生ニューロン / 鎖状細胞移動
Outline of Research at the Start

成体脳内の脳室下帯で産生された新生ニューロンは、細長い細胞塊を作り、交互に足場となりながら、周囲のグリア細胞に作らせたトンネルの内部を移動して、再生に寄与する。しかし、移動・足場形成・トンネル誘導という複数のタスクを交互に分担するヘテロな細胞群としての挙動のメカニズムは不明である。本研究では、この挙動を抽象度の高い数理モデルを用いて群としての移動制御機構を見出すとともに、その基盤となる分子機構を解析し、新生ニューロンが「群」として精緻な脳機能の修復に寄与する群知能的な移動制御メカニズムを解明する。

Outline of Final Research Achievements

Immature new neurons produced in the ventricular-subventricular zone within the adult brain migrate at high speed over long distances and contribute to the regeneration of neural circuits after brain injury. These new neurons form elongated clusters like chains, within which they move over and past one another. This unique mode of migration is thought to be essential for migration in the adult brain tissue, but the relationship between individual behavior in cell groups and behavior as a population has been unclear. In this study, we analyzed the behavior of individual cells in a population in detail by live imaging of newborn neurons migrating in a swarm and by using a highly abstract mathematical model. It was suggested that the diversity and heterogeneity of the behavior of newborn neurons in a swarm contributes to the efficiency of migration as a swarm.

Academic Significance and Societal Importance of the Research Achievements

再生能力の低い霊長類の脳において、数少ない新生ニューロンの移動を効率化させることは、内在性の細胞を用いた傷害の再生に不可欠である。これまで個々の細胞の挙動を制御するメカニズムについては知見が蓄積されてきたが、集団としての移動制御に関しては非常に知見が乏しい。本研究で、集団内でシンクロしない新生ニューロンの個々の挙動のヘテロ性が集団としての移動効率の向上に重要であることが示唆された。これらの成果は、脳疾患の再生医学的アプローチ開発に有用である。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (44 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (31 results) (of which Int'l Joint Research: 1 results,  Invited: 17 results) Remarks (5 results)

  • [Int'l Joint Research] バレンシア大学(スペイン)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] バレンシア大学(スペイン)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] コペンハーゲン大学(デンマーク)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Identification of the growth cone as a probe and driver of neuronal migration in the injured brain2024

    • Author(s)
      Nakajima C、Sawada M、Umeda E、Takagi Y、Nakashima N、Kuboyama K、Kaneko N、Yamamoto S、Nakamura H、Shimada N、Nakamura K、Matsuno K、Uesugi S、Veprek NA、Kuellmer F、Nasufovic V、Uchiyama H、Nakada M、Otsuka Y、Ito Y、Herranz-Perez V、Garcia-Verdugo JM、Ohno N、Arndt H-D、Trauner D、Tabata Y、Igarashi M、Sawamoto K
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 1877-1877

    • DOI

      10.1038/s41467-024-45825-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery2023

    • Author(s)
      Yuya Ohno, Chikako Nakajima, Itsuki Ajioka, Takahiro Muraoka, Atsuya Yaguchi, Teppei Fujioka, Saori Akimoto, Misaki Matsuo, Ahmed Lotfy, Sayuri Nakamura, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Noriyuki Matsukawa, Naoko Kaneko, Kazunobu Sawamoto.
    • Journal Title

      Biomaterials

      Volume: 294 Pages: 122003-122003

    • DOI

      10.1016/j.biomaterials.2023.122003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chitinase-like protein 3: A novel niche factor for mouse neural stem cells2022

    • Author(s)
      Namiki Jun、Suzuki Sayuri、Shibata Shinsuke、Kubota Yoshiaki、Kaneko Naoko、Yoshida Kenji、Yamaguchi Ryo、Matsuzaki Yumi、Masuda Takeshi、Ishihama Yasushi、Sawamoto Kazunobu、Okano Hideyuki
    • Journal Title

      Stem Cell Reports

      Volume: 17 Issue: 12 Pages: 2704-2717

    • DOI

      10.1016/j.stemcr.2022.10.012

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration2021

    • Author(s)
      Yaguchi Atsuya、Oshikawa Mio、Watanabe Go、Hiramatsu Hirotsugu、Uchida Noriyuki、Hara Chikako、Kaneko Naoko、Sawamoto Kazunobu、Muraoka Takahiro、Ajioka Itsuki
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 6623-6623

    • DOI

      10.1038/s41467-021-26896-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates2021

    • Author(s)
      Okada Masayasu、Kawagoe Yosuke、Sato Yuta、Nozumi Motohiro、Ishikawa Yuya、Tamada Atsushi、Yamazaki Hiroyuki、Sekino Yuko、Kanemura Yonehiro、Shinmyo Yohei、Kawasaki Hiroshi、Kaneko Naoko、Sawamoto Kazunobu、Fujii Yukihiko、Igarashi Michihiro
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s13041-021-00755-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 末梢神経軸索再生過程におけるシュワン細胞との相互作用2024

    • Author(s)
      山科孝太、宮本拓哉、齊藤志郎、岩田英敏、齋藤瑳智子、澤本和延、金子奈穂子.
    • Organizer
      第17回神経発生討論会・第20回成体脳のニューロン新生懇談会合同大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 傷害部へ移動する新生ニューロンの足場形成における血管-アストロサイト相互作用2024

    • Author(s)
      石丸大誠,岩田英敏,松本真実,大竹杏佳,Vicente Herranz-Perez,Jose Manuel Garcia Verdugo,澤本和延,金子奈穂子
    • Organizer
      第17回神経発生討論会・第20回成体脳のニューロン新生懇談会合同大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 新生ニューロン集団移動の不均一性の解析2024

    • Author(s)
      蘇武佑里子、金子奈穂子
    • Organizer
      第17回神経発生討論会・第20回成体脳のニューロン新生懇談会合同大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Oligodendrocyte precursor migration to injured brain is assisted by neuroblasts.2024

    • Author(s)
      Edward William Ko Uy、Mayaka Hashimoto、Takuya Miyamoto、Hirohide Takebayashi、Kazunobu Sawamoto、Naoko Kaneko
    • Organizer
      第17回神経発生討論会・第20回成体脳のニューロン新生懇談会合同大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 脳室下帯の細胞構築形成におけるERM蛋白質Ezrinの役割2024

    • Author(s)
      西島邑咲紀、中島徳彦、石崎友崇、田村淳、樋口慧、月田早智子、澤本和延、金子奈穂子
    • Organizer
      第17回神経発生討論会・第20回成体脳のニューロン新生懇談会合同大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 内在性神経幹細胞を生かした脳の再生促進2024

    • Author(s)
      金子奈穂子
    • Organizer
      第23回 日本再生医療学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 大好きなことを仕事に!2024

    • Author(s)
      金子奈穂子
    • Organizer
      第23回 日本再生医療学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 成体脳内で生まれるニューロンの移動制御と傷害脳の再生2023

    • Author(s)
      金子奈穂子
    • Organizer
      第五回 三融会・武田神経科学シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Migration and maturation of new neurons in the post-stroke brain.2023

    • Author(s)
      Naoko Kaneko
    • Organizer
      The 64th Annual Meeting of Japanese Society for Neurochemistry
    • Related Report
      2023 Annual Research Report
  • [Presentation] 成熟脳内で生まれる新しい神経細胞と精神機能2023

    • Author(s)
      金子奈穂子
    • Organizer
      中央区民カレッジ「脳の働きを知り、再生を科学する」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 内在性の神経再生機構の限界と可能性の探究2023

    • Author(s)
      金子奈穂子
    • Organizer
      先端モデル動物支援プラットフォーム2023年度 若手技術支援講習会,
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 脳梗塞後のニューロン再生過程における遅延制御2023

    • Author(s)
      金子奈穂子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Swarm behaviors of newborn neurons for efficient migration2023

    • Author(s)
      Naoko Kaneko
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 傷害脳における新生ニューロン-アストロサイト相互作用とその制御2023

    • Author(s)
      金子奈穂子
    • Organizer
      生理研研究会「多次元脳形態研究会」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 傷害脳を再生するニューロンの細胞骨格ダイナミクス制御2023

    • Author(s)
      金子奈穂子
    • Organizer
      日本化学会第103春季年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 成体脳内の神経幹細胞の分化と傷害脳の再生2023

    • Author(s)
      金子奈穂子
    • Organizer
      第128回日本解剖学会総会・全国学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 脳梗塞後のニューロン再生と機能回復2023

    • Author(s)
      金子奈穂子
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脳を知り、再生に挑む2023

    • Author(s)
      金子奈穂子
    • Organizer
      世界脳週間京都講演会2022年度
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 潜在する再生能力を活用した傷害脳の再生2022

    • Author(s)
      金子奈穂子
    • Organizer
      第14回脳科学若手の会関西部会セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 成体脳で生まれる神経細胞の挙動制御と傷害脳の再生2022

    • Author(s)
      金子奈穂子
    • Organizer
      地方独立行政法人神奈川県立産業技術総合研究所セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 脳の再生能力を考える2022

    • Author(s)
      金子奈穂子
    • Organizer
      脳科学サテライト教室
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Interaction between new neurons and astrocyte in the post-stroke brain2022

    • Author(s)
      Naoko Kaneko
    • Organizer
      第96回日本薬理学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Heterogeneous movement of chain-forming neurons for efficient migration in the adult brain.2022

    • Author(s)
      Naoko Kaneko
    • Organizer
      The 45th Annual Meeting of the Molecular Biology Society of Japan
    • Related Report
      2022 Annual Research Report
  • [Presentation] Swarming migration of new neurons in the adult brain for neuronal regeneration.2022

    • Author(s)
      Naoko Kaneko
    • Organizer
      日本発生生物学会第55回大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] JNK-dependent phosphorylation sites of GAP-43 in the growing axons of rodents and human.2022

    • Author(s)
      Masayasu Okada, Asami Kawasaki, Naoko Kaneko, Motohiro Nozumi, Hiroyuki Yamazaki, Kazunobu Sawamoto, Hayato Fukusumi, Yonehiro Kanemura, Yukihiko Fujii, Michihiro Igarashi.
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 成体脳内で生まれるニューロンの状況依存的な移動・分化2022

    • Author(s)
      金子奈穂子
    • Organizer
      第18回成体脳のニューロン新生懇談会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Adult-born neurons migrate and differentiate in response to the microenvironment in the post-stroke brain.2021

    • Author(s)
      Naoko Kaneko and Kazunobu Sawamoto
    • Organizer
      第44回 日本分子生物学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Neurogenic potential in common marmoset ventricular-subventricular zone during postnatal brain development.2021

    • Author(s)
      Naoko Kaneko, Mariyam Akter, Vicente Herranz-perez, Hisashi Oishi, Jose Manuel Garcia-verdugo, Kazunobu Sawamoto
    • Organizer
      International Society for Stem Cell Research 2021 Tokyo
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成熟脳内で生まれるニューロンの移動制御と傷害の再生2021

    • Author(s)
      金子奈穂子
    • Organizer
      第11回名古屋市立大学IBSセミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 動的な鎖状細胞塊を形成して脳傷害部へ移動する新生神経細胞2021

    • Author(s)
      金子奈穂子, 澤本和延.
    • Organizer
      日本数理生物学会2021年大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 脳梗塞切片を移動する生きた神経細胞の挙動を記録するライブイメージング法2021

    • Author(s)
      金子奈穂子, 澤本和延
    • Organizer
      第11回日本脳血管・認知症学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Remarks] ヘテロ群知能領域HP

    • URL

      https://heteroswarm.org/

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
  • [Remarks] 同志社大学大学院脳科学研究科ホームページ部門紹介

    • URL

      https://brainscience.doshisha.ac.jp/introduction/pat/nr.html

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report 2021 Annual Research Report
  • [Remarks] 金子研究室HP

    • URL

      https://kanekolab.org/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 学術変革領域(B)ヘテロ群知能

    • URL

      https://heteroswarm.org/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 澤本和延研究室ホームページ

    • URL

      http://k-sawamoto.com

    • Related Report
      2021 Annual Research Report

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Published: 2021-10-22   Modified: 2025-01-30  

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