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In Vitro Reconstitution of Multicellular Computing Systems

Planned Research

Project AreaMulticellular neurobiocomputing
Project/Area Number 21H05164
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (IV)
Research InstitutionTohoku University

Principal Investigator

Yamamoto Hideaki  東北大学, 電気通信研究所, 准教授 (10552036)

Co-Investigator(Kenkyū-buntansha) 谷井 孝至  早稲田大学, 理工学術院, 教授 (20339708)
平野 愛弓  東北大学, 電気通信研究所, 教授 (80339241)
Project Period (FY) 2021-08-23 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2023: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2022: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2021: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Keywords多細胞バイオ計算 / 培養神経回路 / リザバーコンピューティング / マイクロ流体デバイス / 多点電極アレイ / 蛍光カルシウムイメージング / 自発活動 / オプトジェネティクス / 数理モデル / スパイキングニューラルネットワーク / カルシウムイメージング / マイクロ加工 / バイオインターフェース / レザバー計算
Outline of Research at the Start

本計画班では,マイクロ加工基板表面に形成した「人工神経細胞回路」(※接続様式が厳密に規定された培養神経回路)とその摂動解析系を基盤として,実神経細胞が構成する多細胞ネットワークの大自由度システムとしての動的特性と自己組織性をボトムアップに解析するための新しい実験系を創成する.そして,マウス大脳皮質視覚野(A03松井班)と運動野(A04正水班)の実細胞モデル系となる階層的フィードフォワード神経回路とリカレント型神経回路を再構成し,A01香取班との連携のもとで,時空間発火パターンの構造基盤を記述する数理モデルを構築する.

Outline of Final Research Achievements

We developed "artificial neuronal networks," i.e., cultured neuronal networks with well-defined connection patterns, and their perturbation analysis systems, and constructively analyzed the dynamical properties of multicellular networks composed of biological neurons. We succeeded in recording and modeling the perturbation responses of artificial neuronal networks with modular structure and in demonstrating the proof-of-concept of physical reservoir computing using biological neurons.

Academic Significance and Societal Importance of the Research Achievements

神経科学の基礎研究・物理リザバーコンピューティング・創薬支援技術などの多くの分野で期待が高まっている培養神経回路を対象として,その構造・機能をマイクロ加工基板やマイクロ流体デバイスを用いて制御する技術を開発した.これにより,生体脳に近い神経細胞ネットワークを培養系で再構築することが可能になった.

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (96 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (6 results) Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (77 results) (of which Int'l Joint Research: 31 results,  Invited: 11 results) Remarks (2 results)

  • [Int'l Joint Research] バルセロナ大学/グラナダ大学(スペイン)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] マックスプランク研究所(ドイツ)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] バルセロナ大学/グラナダ大学/カタルーニャ工科大学(スペイン)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] マックスプランク研究所(ドイツ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] バルセロナ大学/グラナダ大学/カタルーニャ工科大学(スペイン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] マックスプランク研究所(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Enhanced responses to inflammatory cytokine interleukin-6 in micropatterned networks of cultured cortical neurons2024

    • Author(s)
      M. Sakaibara, H. Yamamoto, H. Murota, N. Monma, S. Sato, A. Hirano-Iwata
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 695 Pages: 149379-149379

    • DOI

      10.1016/j.bbrc.2023.149379

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical Study on Physical Reservoir Computing With Josephson Junctions2024

    • Author(s)
      Watanabe Kohki、Mizugaki Yoshinao、Moriya Satoshi、Yamamoto Hideaki、Yamashita Taro、Sato Shigeo
    • Journal Title

      IEEE Transactions on Applied Superconductivity

      Volume: 34 Issue: 3 Pages: 1-4

    • DOI

      10.1109/tasc.2024.3350576

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microfluidics technologies for reconstituting neuronal network functions in vitro2023

    • Author(s)
      山本英明, 平野愛弓, 佐藤茂雄
    • Journal Title

      Oyo Buturi

      Volume: 92 Issue: 5 Pages: 278-282

    • DOI

      10.11470/oubutsu.92.5_278

    • ISSN
      0369-8009, 2188-2290
    • Year and Date
      2023-05-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological neurons act as generalization filters in reservoir computing2023

    • Author(s)
      T. Sumi, H. Yamamoto, Y. Katori, K. Ito, S. Moriya, T. Konno, S. Sato, A. Hirano-Iwata
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 120 Issue: 25 Pages: 1-10

    • DOI

      10.1073/pnas.2217008120

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microfluidic technologies for reconstituting neuronal network functions in vitro2023

    • Author(s)
      H. Yamamoto, A. Hirano-Iwata, S. Sato
    • Journal Title

      JSAP Review

      Volume: 2023 Issue: 0 Pages: n/a

    • DOI

      10.11470/jsaprev.230420

    • ISSN
      2437-0061
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modular architecture facilitates noise-driven control of synchrony in neuronal networks2023

    • Author(s)
      H. Yamamoto, F.P. Spitzner, T. Takemuro, V. Buendia, H. Murota, C. Morante, T. Konno, S. Sato, A. Hirano-Iwata, A. Levina, V. Priesemann, M.A. Munoz, J. Zierenberg, J. Soriano
    • Journal Title

      Science Advances

      Volume: 9 Issue: 34 Pages: 1-12

    • DOI

      10.1126/sciadv.ade1755

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Model-free idealization: Adaptive integrated approach for idealization of ion-channel currents2023

    • Author(s)
      M. Sato, M. Hariyama, M. Komiya, K. Suzuki, Y. Tozawa, H. Yamamoto, A. Hirano-Iwata
    • Journal Title

      Biophysical Journal

      Volume: 122 Issue: 19 Pages: 3959-3975

    • DOI

      10.1016/j.bpj.2023.08.019

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks2023

    • Author(s)
      Sato Yuya、Yamamoto Hideaki、Kato Hideyuki、Tanii Takashi、Sato Shigeo、Hirano-Iwata Ayumi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 16 Pages: 1-11

    • DOI

      10.3389/fnins.2022.943310

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An investigation of the relationship between numerical precision and performance of Q-learning for hardware implementation2022

    • Author(s)
      Oguchi Daisuke、Moriya Satoshi、Yamamoto Hideaki、Sato Shigeo
    • Journal Title

      Nonlinear Theory and Its Applications, IEICE

      Volume: 13 Issue: 2 Pages: 427-433

    • DOI

      10.1587/nolta.13.427

    • ISSN
      2185-4106
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Fully Analog CMOS Implementation of a Two-variable Spiking Neuron in the Subthreshold Region and its Network Operation2022

    • Author(s)
      Moriya Satoshi、Yamamoto Hideaki、Sato Shigeo、Yuminaka Yasushi、Horio Yoshihiko、Madrenas Jordi
    • Journal Title

      2022 International Joint Conference on Neural Networks (IJCNN)

      Volume: - Pages: 1-7

    • DOI

      10.1109/ijcnn55064.2022.9891920

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A subthreshold spiking neuron circuit based on the Izhikevich model2021

    • Author(s)
      Shigeo Sato; Satoshi Moriya; Yuka Kanke; Hideaki Yamamoto; Yoshihiko Horio; Yasushi Yuminaka; Jordi Madrenas
    • Journal Title

      Lecture Notes in Computer Science; Artificial Neural Networks and Machine Learning

      Volume: 12895 Pages: 177-181

    • DOI

      10.1007/978-3-030-86383-8_14

    • ISBN
      9783030863821, 9783030863838
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] シナプススケーリング則の最適化:モジュラスパイキングニューラルネットワークへの適用とその影響の解析2024

    • Author(s)
      新川拓海, 加藤秀行, 石川慶孝, 住 拓磨, 山本英明, 香取勇一
    • Organizer
      電子情報通信学会 非線形問題(NLP)研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Generation of Lorenz attractor by reservoir-based predictive coding in cultured neurons with spiking neural network model2024

    • Author(s)
      Y. Ishikawa, T. Shinkawa, T. Sumi, H. Kato, H. Yamamoto, Y. Katori
    • Organizer
      The 12th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Parameter analysis for biologically plausible learning algorithms for recurrent SNNs: impact of dynamical and anatomical network properties2024

    • Author(s)
      D. Noe, H. Yamamoto, S. Sato
    • Organizer
      The 12th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analog circuit design of multiplicative spike-timing-dependent plasticity in 65-nm CMOS2024

    • Author(s)
      S. Moriya, Y. Iida, H. Yamamoto, S. Sato
    • Organizer
      The 12th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Designing modular neuronal networks with directional connections to enhance dynamical complexity2024

    • Author(s)
      N. Monma, H. Yamamoto, H. Murota, S. Moriya, N. Fujiwara, A.Hirano-Iwata, S. Sato
    • Organizer
      The 12th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of neuronal ensembles by optogenetic stimulation in biological neuronal networks2024

    • Author(s)
      H. Murota, H. Yamamoto, N. Monma, S. Sato, A. Hirano-Iwata
    • Organizer
      The 12th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recovery of neuronal activity in culture and numerical models through functional connectivity reorganization2024

    • Author(s)
      T. Sumi, A. M. Houben, A.-C. H?b, H. Yamamoto, H. Kato, Y. Katori, H. Chiba, J. Soriano, A. Hirano-Iwata
    • Organizer
      The 12th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経細胞ネットワークの機能を理解し応用するための神経工学技術2024

    • Author(s)
      山本英明
    • Organizer
      Beyond AIワークショップ「培養ニューロンの機能と未来」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 脳領域間結合のin vitro再構成に向けたマイクロ流体デバイスの開発2024

    • Author(s)
      遠藤壮太, 山本英明, 西村周泰, 酒井原一守, 門間信明, 正水芳人, 平野愛弓, 佐藤茂雄
    • Organizer
      第71回応用物理学会春季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] In vitro neuroengineering technologies for reconstituting and decoding neuronal network dynamics2023

    • Author(s)
      H. Yamamoto, A. Hirano-Iwata, S. Sato
    • Organizer
      Tohoku NeuroTech Symposium (TNS) 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Physical reservoir computing using dynamics of biological neuronal network with modular structure2023

    • Author(s)
      T. Sumi, H. Yamamoto, Y. Katori, K. Ito, S. Sato, A. Hirano-Iwata
    • Organizer
      10th International Congress on Industrial and Applied Mathematics (ICIAM 2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイクロパターン培養神経ネットワークのダイナミクスを用いたリザバーコンピューティング2023

    • Author(s)
      住 拓磨, 山本英明, 伊藤亘輝, 香取勇一, 佐藤茂雄, 平野愛弓
    • Organizer
      第33回日本神経回路学会全国大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 人工神経細胞回路における摂動応答特性のモジュール構造依存性の解析2023

    • Author(s)
      室田白馬, 山本英明, 竹室汰貴, 佐藤茂雄, J. Soriano, 平野愛弓
    • Organizer
      第33回日本神経回路学会全国大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 結合指向性を有する神経細胞ネットワークの in vitro-in silico モデリング2023

    • Author(s)
      門間信明, 山本英明, 室田白馬, 守谷 哲, 藤原直哉, 平野愛弓, 佐藤茂雄
    • Organizer
      第84回応用物理学会秋季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 大規模モジュール構造型培養神経回路のリザバー特性の解析2023

    • Author(s)
      伊藤亘輝, 山本英明, 住 拓磨, 香取勇一, 佐藤茂雄, 平野愛弓
    • Organizer
      第84回応用物理学会秋季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 人工神経細胞回路における光刺激前後での神経アンサンブルの解析2023

    • Author(s)
      室田白馬, 山本英明, 門間信明, 佐藤茂雄, 平野愛弓
    • Organizer
      第84回応用物理学会秋季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高密度多点電極アレイ上にパターニングしたモジュール構造型大規模培養神経回路の活動解析2023

    • Author(s)
      薗 勇輝, 山本英明, 佐藤有弥, 香取勇一, 平野愛弓, 佐藤茂雄
    • Organizer
      第84回応用物理学会秋季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Bottom-Up Investigation of Multicellular Computing Within Biological Neuronal Networks2023

    • Author(s)
      H. Yamamoto, T. Sumi, Y. Sato, S. Sato, A. Hirano-Iwata
    • Organizer
      2023 International Symposium on Nonlinear Theory and Its Applications (NOLTA2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spiking and Bursting Properties of Spontaneous Activities in Modular Spiking Neuronal Networks2023

    • Author(s)
      H. Kato, T. Shinkawa, Y. Ishikawa, T. Sumi, H. Yamamoto, Y. Katori
    • Organizer
      2023 International Symposium on Nonlinear Theory and Its Applications (NOLTA2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modular Topology Enhances Reservoir Computing Performance in Biological Neuronal Networks2023

    • Author(s)
      T. Sumi, H. Yamamoto, Y. Katori, K. Ito, S. Sato, A. Hirano-Iwata
    • Organizer
      2023 International Symposium on Nonlinear Theory and Its Applications (NOLTA2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Reservoir-Based Predictive Coding in Cultured Neurons with Spiking Neural Network Model2023

    • Author(s)
      Y. Ishikawa, T. Shinkawa, T. Sumi, H. Kato, H. Yamamoto, Y. Katori
    • Organizer
      2023 International Symposium on Nonlinear Theory and Its Applications (NOLTA2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人工神経細胞回路を用いた物理リザバーコンピューティング2023

    • Author(s)
      山本英明, 住 拓磨, 平野愛弓, 佐藤茂雄
    • Organizer
      化学とマイクロ・ナノシステム学会第48回研究会 (CHEMINAS48)
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 生体工学と機械学習による神経回路機能の探求2023

    • Author(s)
      山本英明
    • Organizer
      計測自動制御学会 システム・情報部門 学術講演会 2023 (SSI2023)
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Optogenetic perturbation of engineered neuronal networks grown in vitro2023

    • Author(s)
      H. Yamamoto, S. Sato, A. Hirano-Iwata
    • Organizer
      16th International Symposium on Nanomedicine (ISNM2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Enhanced modulation of spontaneous neural activity by interleukin-6 in micropatterned neuronal networks2023

    • Author(s)
      M. Sakaibara, H. Yamamoto, H. Murota, N. Monma, S. Sato, A. Hirano-Iwata
    • Organizer
      16th International Symposium on Nanomedicine (ISNM2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of synaptic scaling on spontaneous firing activity in spiking neural networks with modular structure2023

    • Author(s)
      T. Shinkawa, H. Kato, Y. Ishikawa, T. Sumi, H. Yamamoto, Y. Katori
    • Organizer
      2023 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing (NCSP'23)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analog CMOS implementation of spiking neural networks for edge computing2023

    • Author(s)
      S. Sato, S. Moriya, H. Yamamoto, Y. Horio, Y. Yuminaka, J. Madrenas
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stimulus responses of modular neuronal networks grown on engineered substrates2023

    • Author(s)
      H. Yamamoto, T. Takemuro, T. Sumi, J. Soriano, S. Sato, A. Hirano-Iwata
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimization of reservoir neural network structure for sensorimotor control2023

    • Author(s)
      A. Fujimoto, H. Yamamoto, S. Moriya, K. Tokuda, Y. Katori, S. Sato
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of synaptic scaling and network size on spontaneous firing activity in spiking neural network2023

    • Author(s)
      T. Shinkawa, H. Kato, Y. Ishikawa, T. Sumi, H. Yamamoto, Y. Katori
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physical reservoir computing with biological neuronal network with modular organization2023

    • Author(s)
      T. Sumi, H. Yamamoto, K. Ito, Y. Katori, S. Sato, A. Hirano-Iwata
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro modeling of neural activity modulation induced by interleukin-62023

    • Author(s)
      M. Sakaibara, H. Yamamoto, H. Murota, S. Sato, A. Hirano-Iwata
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] State transition of spontaneously firing single neurons in autaptic culture upon electric stimulation2023

    • Author(s)
      S. Kishino, N. Mochizuki, A. Hirano-Iwata, H. Yamamoto, T. Tanii
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro reconstruction of artificial neuronal networks with oriented inter-modular connections2023

    • Author(s)
      N. Monma, H. Murota, H. Yamamoto, A. Hirano-Iwata, S. Sato
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of structure-function relationship of micropatterned modular neuronal networks on high-density multi-electrode arrays2023

    • Author(s)
      Y. Sato, H. Yamamoto, H. Kato, T. Tanii, S. Sato, A. Hirano-Iwata
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stimulus responses of micropatterned neuronal networks with modular structure grown on high-density multielectrode arrays2023

    • Author(s)
      Y. Sono, H. Yamamoto, Y. Sato, T. Tanii, A. Hirano-Iwata, S. Sato
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analog LSI implementation of spiking neural network for energy efficient computing2023

    • Author(s)
      S. Moriya, H. Yamamoto, Y. Yuminaka, S. Sato, Y. Horio, J. Madrenas
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analog CMOS implementation of majority circuit with large fan-in for neural network applications2023

    • Author(s)
      S. Ono, S. Moriya, Y. Kanke, H. Yamamoto, Y. Yuminaka, S. Sato
    • Organizer
      The 11th RIEC International Symposium on Brain Functions and Brain Computer (BFBC2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高密度多点電極アレイを用いたモジュール構造型培養神経細胞回路の構造機能相関の解析2023

    • Author(s)
      佐藤有弥, 山本英明, 加藤秀行, 谷井孝至, 佐藤茂雄, 平野愛弓
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高密度多点電極アレイ上にパターニングしたモジュール構造型培養神経回路の刺激応答特性の解析2023

    • Author(s)
      薗 勇輝, 山本英明, 佐藤有弥, 谷井孝至, 平野愛弓, 佐藤茂雄
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 電気刺激による単一神経細胞回路の自発発火頻度の変化2023

    • Author(s)
      岸野颯馬, 望月直樹, 平野愛弓, 山本英明, 谷井孝至
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] マイクロパターン培養神経回路を用いた炎症性サイトカインによる神経活動変調効果のin vitroモデリング2023

    • Author(s)
      酒井原一守, 山本英明, 室田白馬, 佐藤茂雄, 平野愛弓
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大規模モジュール構造型培養神経回路の作製と自発活動の解析2023

    • Author(s)
      伊藤亘輝, 山本英明, 住 拓磨, 室田白馬, 門間信明, 佐藤茂雄, 平野愛弓
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] モジュール構造型培養神経回路のリザバー計算特性の解析2023

    • Author(s)
      住 拓磨, 山本英明, 伊藤亘輝, 香取勇一, 佐藤茂雄, 平野愛弓
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 結合行列の対称性制御によるリカレントニューラルネットワークの構造最適化2022

    • Author(s)
      藤本ありさ, 山本英明, 守谷 哲, 徳田慶太, 香取勇一, 佐藤茂雄
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ニューラルネットワーク応用へ向けたアナログCMOS多数決回路のLSI実装2022

    • Author(s)
      小野哲史, 守谷 哲, 菅家由佳, 山本英明, 弓仲康史, 佐藤茂雄
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 炎症性サイトカインによる神経活動変調効果のin vitroモデリング2022

    • Author(s)
      酒井原 一守, 山本 英明, 佐藤 茂雄, 平野 愛弓
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高密度多点電極アレイ上でのモジュール構造型培養神経回路のパターニング2022

    • Author(s)
      佐藤 有弥, 山本 英明, 住 拓磨, 谷井 孝至, 佐藤 茂雄, 平野 愛弓
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] ボトムアップアプローチによる神経回路機能の探求と応用2022

    • Author(s)
      山本英明
    • Organizer
      第21回 ExCELLSセミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] モジュール構造型人工神経細胞回路の摂動応答特性2022

    • Author(s)
      山本 英明, 竹室 汰貴, 住 拓磨, 金野 智浩, Jordi Soriano, 平野 愛弓
    • Organizer
      第83回秋季応用物理学会学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] マイクロパターン基板を用いた神経回路機能の実細胞再構成2022

    • Author(s)
      山本英明
    • Organizer
      第83回秋季応用物理学会学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] モジュール間結合に指向性を有する人工神経細胞回路の作製と自発活動解析2022

    • Author(s)
      門間 信明, 山本 英明, 守谷 哲, 平野 愛弓, 佐藤 茂雄
    • Organizer
      第83回秋季応用物理学会学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高密度多点電極アレイ上への神経細胞回路のパターニングと構造機能相関の解析2022

    • Author(s)
      佐藤 有弥, 山本 英明, 加藤 秀行, 谷井 孝至, 佐藤 茂雄, 平野 愛弓
    • Organizer
      第83回秋季応用物理学会学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 神経アンサンブルの機能特性解析のための人工神経細胞回路の構築2022

    • Author(s)
      室田白馬, 山本英明, 住 拓磨, 佐藤茂雄, 平野愛弓
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] スパイキングニューラルネットワークのアナログ回路実装と時系列情報処理への応用2022

    • Author(s)
      守谷 哲, 山本英明, 弓仲康史, 佐藤茂雄, 堀尾喜彦
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Ultra-low power analog CMOS implementation of spiking neural networks for reservoir computing applications2022

    • Author(s)
      S. Moriya, H. Yamamoto, S. Sato, Y. Yuminaka, Y. Horio, J. Madrenas
    • Organizer
      2022 International Symposium on Nonlinear Theory and Its Applications (NOLTA2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Time-series classification in micropatterned neuronal network reservoirs2022

    • Author(s)
      T. Sumi, H. Yamamoto, Y. Katori, K. Ito, S. Sato, A. Hirano-Iwata
    • Organizer
      2022 International Symposium on Nonlinear Theory and Its Applications (NOLTA2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 減衰付きSTDP学習則のアナログ回路設計とLSI実装2022

    • Author(s)
      守谷 哲, 加藤達暉, 弓仲康史, 山本英明, 佐藤茂雄, 堀尾喜彦
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ニューロン回路への応用を目的としたアナログCMOS多数決回路の設計2022

    • Author(s)
      小野哲史, 守谷 哲, 菅家由佳, 山本英明, 弓仲康史, 佐藤茂雄
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The launch of "Multicellular Neurobiocomputing"2022

    • Author(s)
      H. Yamamoto, Y. Katori, T. Matsui, Y. Masamizu
    • Organizer
      The 1st Symposium on Multicellular Neurobiocomputing (The 10th RIEC International Symposium on Brain Functions and Brain Computer)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Spiking neuron circuit and efficient CMOS reservoir computing2022

    • Author(s)
      S. Sato, S. Moriya, S. Ono, Y. Kanke, H. Yamamoto, Y. Horio, Y. Yuminaka, J. Madrenas
    • Organizer
      The 10th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dynamical richness defined by modular organization in engineered neuronal networks2022

    • Author(s)
      山本英明, 平野愛弓, 佐藤茂雄
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Artificial reconstitution of neuronal network functions with living cells2022

    • Author(s)
      H. Yamamoto, T. Sumi, T. Takemuro, S. Moriya, S. Sato, A. Hirano-Iwata
    • Organizer
      The 3rd International Symposium on Neuromorphic AI Hardware
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 薄膜型マイクロ流体デバイスを用いた神経細胞モジュール間の結合指向性制御2022

    • Author(s)
      門間信明, 山本英明, 竹室汰貴, 守谷 哲, 藤本ありさ, 本田 渉, 平野愛弓, 佐藤茂雄
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 神経アンサンブルの機能特性のin vitroモデリングに向けた薄膜型マイクロ流体デバイスの作製2022

    • Author(s)
      室田白馬, 山本英明, 竹室汰貴, 門間信明, 佐藤茂雄, 平野愛弓
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 電気刺激による神経細胞回路の自発発火頻度の変調2022

    • Author(s)
      岸野颯馬, 鞍掛碧流, 望月直樹, 平野愛弓, 山本英明, 谷井孝至
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイクロパターン培養神経回路に対する光摂動系の構築2021

    • Author(s)
      竹室汰貴, 山本英明, 脇村 桂, 住 拓磨, 金野智浩, 佐藤茂雄, Jordi Soriano, 平野愛弓
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 多点電極アレイ上でのモジュール構造型培養神経回路のパターニング2021

    • Author(s)
      佐藤有弥, 山本英明, 竹室汰貴, 住 拓磨, 酒井原一守, 谷井孝至, 佐藤茂雄, 平野愛弓
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 帰還接続における伝搬遅延によるSTDPシナプスの選別2021

    • Author(s)
      望月直樹, 石田実穂子, 鞍掛碧流, 池田 翔, 山本英明, 平野愛弓, 谷井孝至
    • Organizer
      第31回日本神経回路学会全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] リカレントニューラルネットワークの固有値分布における対称性解析2021

    • Author(s)
      藤本ありさ, 山本英明, 守谷 哲, 佐藤茂雄
    • Organizer
      第31回日本神経回路学会全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 人工神経回路への 2 針電極による刺激と応答計測2021

    • Author(s)
      鞍掛碧流, 望月直樹, 池田 翔, 岸野颯馬, 小熊奏一郎, 藤原 彩, 山本英明, 平野愛弓, 谷井孝至
    • Organizer
      第31回日本神経回路学会全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] リザバー計算に基づく人工神経細胞回路のパターン分類特性の評価2021

    • Author(s)
      住 拓磨, 山本英明, 守谷 哲, 竹室汰貴, 金野智浩, 佐藤茂雄, 平野愛弓
    • Organizer
      第31回日本神経回路学会全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイクロパターン培養神経回路のリザバー計算特性の解析2021

    • Author(s)
      住 拓磨, 山本英明, 守谷 哲, 竹室汰貴, 金野智浩, 佐藤茂雄, 平野愛弓
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] FPGA実装に向けた強化学習モデルの丸め誤差と学習性能に関する考察2021

    • Author(s)
      小口大輔, 守谷 哲, 山本英明, 佐藤茂雄
    • Organizer
      電子情報通信学会 ニューロコンピューティング(NC)研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] バイオ界面制御による神経回路機能の人工再構成2021

    • Author(s)
      山本英明, 平野愛弓, 佐藤茂雄
    • Organizer
      薄膜材料デバイス研究会第18回研究集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Polydimethylsiloxane microfluidic films for in vitro engineering of mesoscale neuronal networks2021

    • Author(s)
      H. Yamamoto, T. Takemuro, N. Monma, S. Sato, A. Hirano-Iwata
    • Organizer
      14th International Symposium on Nanomedicine (ISNM2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] An investigation of the Relationship between numerical precision and performance of Q-learning for hardware implementation2021

    • Author(s)
      D. Oguchi, S. Moriya, H. Yamamoto, S. Sato
    • Organizer
      The 2021 Nonlinear Science Workshop (NLSW2021)
    • Related Report
      2021 Annual Research Report
  • [Remarks] 領域ホームページ

    • URL

      https://www.mnbc.riec.tohoku.ac.jp/

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
  • [Remarks] 領域ホームページ

    • URL

      https://www.mnbc.riec.tohoku.ac.jp/index.html

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2021-10-22   Modified: 2025-01-30  

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