| Budget Amount *help |
¥110,370,000 (Direct Cost: ¥84,900,000、Indirect Cost: ¥25,470,000)
Fiscal Year 2014: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2012: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2011: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2010: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
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| Outline of Final Research Achievements |
Selective hydroxylation of hydrocarbons is one of the most important but is still very difficult chemical transformation reactions in synthetic organic chemistry and industrial chemistry. In this study, we have developed transition-metal active-oxygen speceis supported by simple pyridyl(alkylamine) ligands, which are capable of performing selective hydroxylation reactions of aliphatic and aromatic compounds using molecular oxygen or hydrogen peroxide as an oxidant. We have also succeeded to developed osmium complexes supported by the same series of pyridyl(alkylamine) ligands, which can catalyze efficient cis-dihydroxylation and 1,2-aminohydroxylation reactions of olefins. Mechanistic studies on the above reactions have been performed in detail to get insights into the structure and properties of the transition-metal active-oxygen intermediates.
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