| Budget Amount *help |
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2012: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
In the active site of enzymes, reactive species that are very unstable in artificial systems are sometimes stabilized and play an important role in bioactivation of substrate molecules with extraordinarily high reactivity. For modeling such fabulous features of enzymatic reactions, various types of nano-sized molecular cavities were synthesized and applied to molecular activation. Development of novel synthetic reactions by taking advantage of unique features of reactive intermediates of enzymatic reactions as well as modeling of bioactivation of small molecules such as reactive nitrogen species were investigated.
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