| Budget Amount *help |
¥73,970,000 (Direct Cost: ¥56,900,000、Indirect Cost: ¥17,070,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2013: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2012: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2011: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2010: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Outline of Final Research Achievements |
In this study, we have been studying nitric oxide reductase (NOR), which catalyzes NO reduction to N2O in anaerobic respiration (denitrification) of bacteria. We succeeded in proposing the molecular mechanism of the NOR reaction on the basis of its molecular structure, in which the N-O bond is cleaved and the N-N bond is formed. The results provided us the new insight into development of a new type of the catalyst, since NOR utilizes two-iron-complex as the active center, instead of rare-metals, which are usually used in the organic synthesis. In addition, our study can contribute to the discussion of the molecular evolution of the respiratory enzymes on the earth, which was evolved from anaerobic (non-oxygen) to aerobic (oxygen) respiration.
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