| Budget Amount *help |
¥115,180,000 (Direct Cost: ¥88,600,000、Indirect Cost: ¥26,580,000)
Fiscal Year 2014: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2012: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2011: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2010: ¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
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| Outline of Final Research Achievements |
Biosynthesis and metabolic degradation are one of the fundamental examples which are related to the straight toward organic synthesis. The efficient reactions require enzymes as a biocatalyst. Therefore, it will be an appropriate approach for chemists to modify a protein to yield a useful catalyst. Our group has focused on the construction of a biohybrid catalyst in which an artificially created metal complex is linked into an aproprotein after the removal of a cofactor heme of a hemoprotein. As a result, we have demonstrated that several biohybrid catalysts can promote reactions such as C-H bond activation, C-C bond formation or hydrogen evolution which seems to be difficult for natural enzymes. Furthermore, we indicate that the fine-tuning of the reaction scaffold of our biohybrid catalyst by mutagenetic approach is capable of controlling the reaction activity and stereoselectivity.
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