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Control of Structure of Fusion Materials using Artificial Proteins with Functionality

Planned Research

Project AreaFusion Materials: Creative Development of Materials and Exploration of Their Function through Molecular Control
Project/Area Number 22107009
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

ARAKAKI Atsushi  東京農工大学, 工学(系)研究科(研究院), 准教授 (10367154)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥57,720,000 (Direct Cost: ¥44,400,000、Indirect Cost: ¥13,320,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Keywordsハイブリッド材料 / 機能性高分子 / 融合マテリアル / 生体材料 / バイオテクノロジー
Outline of Final Research Achievements

Biominerals show elaborate architecture and specific property which depends on their composition, size, shape, and crystal structure. Molecular studies on biomineralization have shown that the process involves a number of proteins. For structure control of novel fusion materials, we analyze the function of four Mms proteins that are involved in the formation of magnetite crystals in magnetotactic bacteria. All Mms proteins were shown to play key roles in crystal growth and in defining the surface structures of magnetite crystal. By using the protein, morphology of magnetite crystals was successfully controlled according to protein expression levels in bacterial cell.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (58 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (36 results) (of which Invited: 5 results) Book (5 results) Remarks (2 results)

  • [Journal Article] Biomineralization-Inspired Synthesis of Functional Organic/Inorganic Hybrid Materials: Organic Molecular Control of Self-Organization of Hybrids2015

    • Author(s)
      Atsushi Arakaki, Katsuhiko Shimizu, Mayumi Oda, Takeshi Sakamoto, Tatsuya Nishimura, and Takashi Kato
    • Journal Title

      Org. Biomol. Chem.

      Volume: 13 Issue: 4 Pages: 974-989

    • DOI

      10.1039/c4ob01796j

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bioinspired Magnetite Crystallization Directed by Random Copolypeptides2015

    • Author(s)
      Jos J. M. Lenders, Harshal R. Zope, Ayana Yamagishi, Paul H. H. Bomans, Atsushi Arakaki, Alexander Kros, Gijsbertus de With and Nico A. J. M. Sommerdijk
    • Journal Title

      Adv. Funct. Mater.

      Volume: 25 Pages: 711-719

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coordinated Functions of Mms Proteins Define the Surface Structure of Cubo-octahedral Magnetite Crystals in Magnetotactic Bacteria2014

    • Author(s)
      Atsushi Arakaki, Ayana Yamagishi, Ayumi Fukuyo, Masayoshi Tanaka, and Tadashi Matsunaga
    • Journal Title

      Mol. Microbiol.

      Volume: 93 Issue: 3 Pages: 554-567

    • DOI

      10.1111/mmi.12683

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 磁性細菌における磁気微粒子の形態制御機構の解析と応用2014

    • Author(s)
      新垣篤史
    • Journal Title

      Colloid and Interface Communication

      Volume: 39 Pages: 1-3

    • NAID

      40020187425

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Glycosylceramides from marine green microalga Tetraselmis sp.2013

    • Author(s)
      Atsushi Arakaki
    • Journal Title

      Phytochemistry

      Volume: 85 Pages: 107-114

    • DOI

      10.1016/j.phytochem.2012.09.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biologically synthesized or bioinspired process-derived iron oxides as catalysts for living cationic polymerization of a vinyl ether2012

    • Author(s)
      Kanazawa A
    • Journal Title

      CHEMICAL COMMUNICATIONS

      Volume: 48 Pages: 10904-10906

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient DNA release from PAMAM dendrimer-modified superpar amagnetic nanopar tides for DNA recovery2012

    • Author(s)
      Atsushi Arakaki, ほか10名
    • Journal Title

      Polymer Journal

      Volume: (In press) Issue: 6 Pages: 672-677

    • DOI

      10.1038/pj.2012.32

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of magnetic nanoparticles modified with thiol core, functionalized PAMAM dendron for DNA recovery2012

    • Author(s)
      Tsuyoshi Tanaka, Atsushi Arakaki, ほか10名
    • Journal Title

      J.Colloid Interface Sci.

      Volume: (In press) Issue: 1 Pages: 469-475

    • DOI

      10.1016/j.jcis.2012.03.039

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 有機分子の制御による異方的結晶成長と無機/有機ハイブリッド構造の形成2012

    • Author(s)
      坂本健
    • Journal Title

      セラミックス

      Volume: 47 Pages: 285-290

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 微生物が合成する磁性ナノ粒子:その合成機構の解析とバイオ応用2012

    • Author(s)
      新垣篤史
    • Journal Title

      日本磁気学会誌 まぐね

      Volume: 7 Pages: 154-161

    • NAID

      10030958863

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 有機分子の制御による異方的結晶成長と無機/有機ハイブリッド構造の形成2012

    • Author(s)
      坂本健、新垣篤史、清水克彦、西村達也、加藤隆史
    • Journal Title

      CERAMICS JAPAN

      Volume: 47 Pages: 285-290

    • NAID

      10031155536

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Magnetic bacterial protein Mms6 controls morphology, crystallinity and magnetism of cobalt-doped magnetite nanoparticles in vitro2011

    • Author(s)
      Johanna M Galloway, Atsushi Arakaki, ほか4名
    • Journal Title

      J.Mater.Chem.

      Volume: 21 Issue: 39 Pages: 15244-15254

    • DOI

      10.1039/c1jm12003d

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mms6 protein regulates crystal morphology during nano-sized magnetite biomineralization in vivo2011

    • Author(s)
      M.Tanaka, E.Mazuyama, A.Arakaki, T.Matsunaga
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Pages: 6386-6392

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 磁石を作る細菌のゲノム2010

    • Author(s)
      松永是、新垣篤史
    • Journal Title

      生物の科学

      Volume: 64 Pages: 85-91

    • NAID

      40017430465

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ナノ磁石を合成する細胞内小器官2010

    • Author(s)
      新垣篤史
    • Journal Title

      化学

      Volume: 65 Pages: 68-69

    • Related Report
      2010 Annual Research Report
  • [Presentation] Control of Magnetite Morphology by Regulating Expression of Mms Protein in Magnetotactic Bacteria2014

    • Author(s)
      Atsushi Arakaki, Ayana Yamagishi, Tadashi Matsunaga
    • Organizer
      The 2nd International Symposium on Fusion Materials
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Year and Date
      2014-11-02 – 2014-11-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional Analysis of Crystal Morphology Regulator Protein Mms from Magnetotactic Bacteria by Partial Deletion of Amino Acid Sequence2014

    • Author(s)
      Ayana Yamagishi, Kaori Narumiya, Tadashi Matsunaga, Atsushi Arakaki
    • Organizer
      The 2nd International Symposium on Fusion Materials
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Year and Date
      2014-11-02 – 2014-11-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 磁性細菌における磁気微粒子形態制御タンパク質の部分配列欠損による機能解析2014

    • Author(s)
      成宮香織, 山岸彩奈, 松永是, 新垣篤史
    • Organizer
      第4回CSJ化学フェスタ2014
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 磁性細菌が作る酸化鉄ナノクリスタルの形成機構2014

    • Author(s)
      新垣篤史
    • Organizer
      日本セラミックス協会 第27回秋季シンポジウム
    • Place of Presentation
      鹿児島大学、鹿児島
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 磁性細菌における酸化鉄磁気微粒子の形態制御機構2013

    • Author(s)
      新垣篤史
    • Organizer
      日本農芸化学会 2013年度大会
    • Place of Presentation
      東北大学、仙台
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Morphology control mechanism of iron oxide crystals in magnetotactic bacteria2013

    • Author(s)
      Atsushi Arakaki
    • Organizer
      The 3rd International Symposium on Life Science in Toyama
    • Place of Presentation
      富山大学、富山
    • Year and Date
      2013-03-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Understanding of Biomineralization Mechanism in Magnetotactic Bacteria toward Designed Synthesis of Iron Oxide Nano-Particle2013

    • Author(s)
      A. Arakaki
    • Organizer
      The 11th International Conference on Ferrites (ICF11)
    • Place of Presentation
      Okinawa Convention Center
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 酸化鉄バイオミネラリゼーションに関わるMms6タンパク質の部分配列欠損による機能領域の同定2013

    • Author(s)
      新垣篤史
    • Organizer
      第15回マリンバイオテクノロジー学会大大会
    • Place of Presentation
      沖縄県市町村自治会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] アミノ酸配列への変異導入による酸化鉄バイオミネラリゼーションタンパク質の機能領域の同定2013

    • Author(s)
      新垣篤史
    • Organizer
      第62回高分子討論会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 磁性細菌の遺伝子組換えによる磁気微粒子の形態制御2012

    • Author(s)
      新垣篤史
    • Organizer
      新学術領域研究 若手合同シンポジウム 「配位プログラム」×「融合マテリアル」
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2012-12-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 磁性細菌の遺伝子組換えによる磁性粒子の形態制御2012

    • Author(s)
      新垣篤史
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Control of magnetite crystal shape in magnetotactic bacteria2012

    • Author(s)
      Atsushi Arakaki
    • Organizer
      Gordon Research Conferences 2012 (Biomineralization)
    • Place of Presentation
      Colby-Sawyer College, New London, NH, USA
    • Year and Date
      2012-08-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Coordinating Expression of Mms Proteins Regulates Surface Structure of Cubo-octahedral Magnetite Crystal in Magnetospirillum magneticum Strain AMB-12012

    • Author(s)
      Atsushi Arakaki
    • Organizer
      The 3rd International Magnetotactic Bacteria Meeting (MTB2012)
    • Place of Presentation
      UC Berkeley, Berkeley, CA, USA
    • Year and Date
      2012-06-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Morphological Control of Magnetite Nanoparticles in Magnetotactic Bacteria2012

    • Author(s)
      Atsushi Arakaki
    • Organizer
      2012 MRS Spring Meeting
    • Place of Presentation
      Moscone West Convention Center, San Francisco, CA, USA
    • Year and Date
      2012-04-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 結晶形態制御タンパク質の多重遺伝子欠損磁性細菌株が合成する酸化鉄磁気微粒子の形態解析2012

    • Author(s)
      福世亜由美
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海洋微細藻類由来の新規glycosylceramidesの単離と構造同定2012

    • Author(s)
      梁越
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 人工機能化タンパク質を用いた融合マテリアルの構造制御2012

    • Author(s)
      新垣篤史
    • Organizer
      新学術領域研究「融合マテリアル」第4回公開シンポジウム
    • Place of Presentation
      大阪大学中之島センター、大阪
    • Year and Date
      2012-01-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] in vivoにおける磁性細菌粒子の形態制御2011

    • Author(s)
      山岸彩奈
    • Organizer
      第6回バイオミネラリゼーションワークショップ
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Morphology control of magnetite crystals in magnetotactic bacteria2011

    • Author(s)
      Atsushi Arakaki
    • Organizer
      The 1st International Symposium on Fusion Materials
    • Place of Presentation
      Toba Hotel International, Mie, Japan(招待講演)
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Conformational change upon iron-binding of morphology controlling proteins from bacterial magnetic particles2011

    • Author(s)
      Mayumi Oda
    • Organizer
      The 1st International Symposium on Fusion Materials
    • Place of Presentation
      Toba Hotel International, Mie, Japan
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質のバイオミネラリゼーション機能を利用した磁性酸化鉄微粒子の合成2011

    • Author(s)
      新垣篤史
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学、岡山
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 磁性細菌粒子の形態制御タンパク質の鉄イオンとの相互作用に伴う構造変化2011

    • Author(s)
      小田真弓
    • Organizer
      第63回日本生物工学会大会
    • Place of Presentation
      東京農工大学、東京
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] mms7遺伝子の発現調節による磁性細菌粒子の形態制御2011

    • Author(s)
      山岸彩奈
    • Organizer
      第63回日本生物工学会大会
    • Place of Presentation
      東京農工大学、東京
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of influenza virus gene detection technique based on localized heating of magnetic nanoparticles2011

    • Author(s)
      Mami Takahashi
    • Organizer
      The 62nd Annual Meeting of the International Society of Electrochemistry
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2011-09-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 人工機能化タンパク質を用いた融合マテリアルの構造制御2011

    • Author(s)
      新垣篤史
    • Organizer
      新学術領域研究「融合マテリアル」第2回公開シンポジウム
    • Place of Presentation
      福岡ガーデンパレス、福岡
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] High density microcavity array for target cell analysis from heterogeneous cell populations2010

    • Author(s)
      Atsushi Arakaki
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Magnetite synthesis by mimic peptides from the Mms6 protein of magnetotactic bacteria2010

    • Author(s)
      Atsushi Arakaki
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protein-mediated morphological control of magnetite crystal in magnetotactic bacteha2010

    • Author(s)
      Atsushi Arakaki
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA(招待講演)
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁性細菌の酸化鉄結晶形成に関与するmms5遺伝子の機能解析2010

    • Author(s)
      福世亜由美
    • Organizer
      第5回バイオミネラリゼーションワークショップ
    • Place of Presentation
      東京大学弥生講堂、東京
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁性細菌から分離されたMms6タンパク質の鉄イオンの相互作用に伴う構造変化2010

    • Author(s)
      小田真弓
    • Organizer
      第5回バイオミネラリゼーションワークショップ
    • Place of Presentation
      東京大学弥生講堂、東京
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁性細菌のマグネタイト結晶形成に関与するmms5遺伝子の解析2010

    • Author(s)
      福世亜由美
    • Organizer
      第62回日本生物工学会大会
    • Place of Presentation
      宮崎シーガイア、宮崎
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁性細菌の遺伝子欠損株を用いた磁気微粒子形態制御機構の解析2010

    • Author(s)
      新垣篤史
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪大学、大阪
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Iron-binding protein Mms6 regulates crystal surface structure of magnetite in Magnetospirillum magneticum AMB-12010

    • Author(s)
      Atsushi Arakaki
    • Organizer
      Symposium on Magnetotactic Bacteria and Biomineralization
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Control over the morphology of magnetite crystal by the Mms6 protein in magnetotactic bacteria2010

    • Author(s)
      Atsushi Arakaki
    • Organizer
      Gordon Research Conferences (Biomineralization)
    • Place of Presentation
      New London, NH, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細菌が合成するナノ磁石の形態制御機構

    • Author(s)
      新垣篤史
    • Organizer
      EIIRIS特別講演会
    • Place of Presentation
      豊橋技術科学大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Morphology Change of Magnetite from Bullet-Shape to Cubo-Octahedron in Magnetotactic Bacteria

    • Author(s)
      A. Arakaki
    • Organizer
      Fusion Materials Meeting
    • Place of Presentation
      The University of Tokyo
    • Related Report
      2013 Annual Research Report
  • [Book] 地球を救うメタルバイオテクノロジー -微生物と金属資源のはなし-「第3章 3.3.3 磁性細菌の機能を利用した磁性材料の合成技術」を分担執筆2014

    • Author(s)
      新垣篤史、山岸彩奈、松永 是(編著/山下光雄、清 和成)
    • Total Pages
      242
    • Publisher
      成山堂書店
    • Related Report
      2014 Annual Research Report
  • [Book] 生物模倣技術と新材料・新製品開発への応用「第5章 第1節 磁性細菌の磁気微粒子形態制御機構の解析と磁性材料合成への応用」を分担執筆2014

    • Author(s)
      新垣篤史、山岸彩奈、松永 是(監修/文部科学省 科学研究費新学術領域「生物規範工学」、高分子学会 バイオミメティクス研究会、エアロアクアバイオメカニズム学会)
    • Total Pages
      702
    • Publisher
      監修/文部科学省 科学研究費新学術領域「生物規範工学」, 高分子学会 バイオミメティクス研究会, エアロアクアバイオメカニズム学会
    • Related Report
      2014 Annual Research Report
  • [Book] Molecular Bioengineering of Magnetosomes for Biotechnological Applications, In Coordination Chemistry in Protein Cages2013

    • Author(s)
      A. Arakaki, M. Nemoto, T. Matsunaga
    • Publisher
      Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] Chapter 10 'Molecular Bioengineering of Magnetosomes for Biotechnological Applications', Coordination Chemistry in Protein Cages: Principles, Design, and Applications2013

    • Author(s)
      Atsushi Arakaki
    • Total Pages
      25
    • Publisher
      Wiley
    • Related Report
      2012 Annual Research Report
  • [Book] Molecular Bioengineering of Magnetosomes for Biotechnological Applications in "Coordination Chemistry in Protein Cages-Understanding, Design, and Applications- (ED: Profs Takafumi Ueno and Yoshihito Watanabe)"2012

    • Author(s)
      Atsushi Arakaki, Michiko Nemoto, Tadashi Matsunaga
    • Total Pages
      20
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2011 Annual Research Report
  • [Remarks] 生命分子工学・海洋生命工学研究室

    • URL

      http://www.tuat.ac.jp/~biomol/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 生命分子工学・海洋生命工学研究室

    • URL

      http://www.tuat.ac.jp/~biomol/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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