• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on biosynthetic assembly line of meroterpenoids

Planned Research

Project AreaBiosynthetic machinery: Deciphering and regulating the system for bioactive metabolite diversification
Project/Area Number 22108004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionThe University of Tokyo

Principal Investigator

ABE IKURO  東京大学, 薬学研究科(研究院), 教授 (40305496)

Co-Investigator(Kenkyū-buntansha) MATSUDA Yudai  東京大学, 大学院薬学系研究科, 助教 (10720766)
Co-Investigator(Renkei-kenkyūsha) WAKIMOTO Toshiyuki  東京大学, 大学院薬学系研究科, 准教授 (70363900)
AWAKAWA Takayoshi  東京大学, 大学院薬学系研究科, 助教 (80609834)
MORITA Hiroyuki  東京大学, 大学院薬学系研究科, 助教 (20416663)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥55,640,000 (Direct Cost: ¥42,800,000、Indirect Cost: ¥12,840,000)
Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsメロテルペノイド / 生合成 / 遺伝子クラスター / 多様性創出 / 機能制御 / 二次代謝酵素 / 酵素 / 遺伝子 / 生合成クラスター / 生合成工学
Outline of Final Research Achievements

Meroterpenoids are hybrid natural products of both terpenoid and polyketide origin. We identified several biosynthetic gene clusters of pharmaceutically important fungal meroterpenoids, which includes that is responsible for the production of pyripyropene A, terretonin, anditomin, and andrastin, through reconstituted biosynthesis in a heterologous fungal expression system. Interestingly, the biosynthetic assembly lines are rich sources for interesting enzymes and chemistry, such as previously unknown membrane-bound terpene cyclases and multifunctional oxygenases, for the generation of structurally divergent complex fungal meroterpenoids.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (65 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (31 results) (of which Peer Reviewed: 31 results,  Acknowledgement Compliant: 5 results,  Open Access: 3 results) Presentation (26 results) (of which Invited: 13 results) Book (2 results) Remarks (5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase2015

    • Author(s)
      Matsuda, Y., Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 137 Issue: 9 Pages: 3393-3401

    • DOI

      10.1021/jacs.5b00570

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid2014

    • Author(s)
      Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 136 Issue: 43 Pages: 15326-15336

    • DOI

      10.1021/ja508127q

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis2014

    • Author(s)
      Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 136 Issue: 28 Pages: 9910-9913

    • DOI

      10.1021/ja505224r

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont2014

    • Author(s)
      Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I.
    • Journal Title

      Nature Chem. Biol.

      Volume: 10 Issue: 8 Pages: 648-655

    • DOI

      10.1038/nchembio.1573

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An environmental bacterial taxon with a large and distinct metabolic repertoire2014

    • Author(s)
      Wilson, M. C., Mori, T., Ruckert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crusemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
    • Journal Title

      Nature

      Volume: 506 Issue: 7486 Pages: 58-62

    • DOI

      10.1038/nature12959

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis2013

    • Author(s)
      Y. Matsuda, T. Awakawa, T. Wakimoto, and I. Abe
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 30 Pages: 10962-10965

    • DOI

      10.1021/ja405518u

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstituted biosynthesis of fungal meroterpenoid andrastin A2013

    • Author(s)
      Matsuda, Y., Awakawa, T., Abe, I.
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 38 Pages: 8199-8204

    • DOI

      10.1016/j.tet.2013.07.029

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from Citrus microcarpa2013

    • Author(s)
      Mori, T., Shimokawa, Y., Matsui, T., Kinjo, K., Kato, R., Noguchi, H., Sugio, S., Morita, H., Abe, I.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 40 Pages: 28845-28858

    • DOI

      10.1074/jbc.m113.493155

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility2013

    • Author(s)
      Yan Y., Chen, J., Zhang, L., Zheng, Q., Han, Y., Zhang, H., Awakawa, T., Abe, I., Liu, W.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 52 Issue: 47 Pages: 12308-12312

    • DOI

      10.1002/anie.201305569

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid2012

    • Author(s)
      Itoh, T.
    • Journal Title

      ChemBioChem

      Volume: 13 Issue: 8 Pages: 1132-1135

    • DOI

      10.1002/cbic.201200124

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terretonin biosynthesis requires methylation as essential step for cyclization.2012

    • Author(s)
      Y. Matsuda, T. Awakawa, T. Itoh, T. Wakimoto, T. Kushiro, I. Fujii, Y. Ebizuka, I. Abe
    • Journal Title

      ChemBioChem

      Volume: 13(12) Issue: 12 Pages: 1738-1741

    • DOI

      10.1002/cbic.201200369

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis: an HR-PKS stereo surprise2012

    • Author(s)
      Abe, I.
    • Journal Title

      Nature Chemical Biology

      Volume: 8 Issue: 4 Pages: 322-323

    • DOI

      10.1038/nchembio.924

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineering of plant type III polyketide synthases2012

    • Author(s)
      Wakimoto, I.
    • Journal Title

      Methods in Enzymology

      Volume: 51 Pages: 337-358

    • DOI

      10.1016/b978-0-12-394290-6.00016-1

    • ISBN
      9780123942906
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenylation of a nonaromatic carbon of indolylbutenone by a fungal indole prenyltransferase2012

    • Author(s)
      Chen, J.
    • Journal Title

      Organic Letters

      Volume: 14 Issue: 12 Pages: 3080-3083

    • DOI

      10.1021/ol301129x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic pathway for highly structural diversity of a common dilactone core in antimycin production2012

    • Author(s)
      Yan, Y.
    • Journal Title

      Organic Letters

      Volume: 14 Issue: 16 Pages: 4142-4145

    • DOI

      10.1021/ol301785x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel applications of plant polyketide synthases2012

    • Author(s)
      Abe, I.
    • Journal Title

      Current Opinion in Chemical Biology

      Volume: 16 Pages: 179-185

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, purification, and crystallization of an indole prenyltransferase from Aspergillus fumigatus2012

    • Author(s)
      Chen, J., Morita, H., Kato, R., Noguchi, H., Sugio, S., Abe, I.
    • Journal Title

      Acta Crystallogr., Sect.F : Struct.Biol.Cryst.Commun.

      Volume: 68 Issue: 3 Pages: 355-358

    • DOI

      10.1107/s1744309112004964

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benzophenone synthase from Garcinia mangostana L.pericarps2012

    • Author(s)
      Natsajee Nualkaew, Hiroyuki Morita, Yoshihiko Shimokawa, Keishi Kinjo, Tetsuo Kushiro, Wanchai De-Eknamkul, Yutaka Ebizuka, Ikuro Abe
    • Journal Title

      Phytochem.

      Volume: 77 Pages: 60-69

    • DOI

      10.1016/j.phytochem.2012.02.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benzalacetone synthase2012

    • Author(s)
      Yoshihiko Shimokawa, Hiroyuki Morita, Ikuro Abe
    • Journal Title

      Frontiers in Plant Science

      Volume: 3 Pages: 57-57

    • DOI

      10.3389/fpls.2012.00057

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid2012

    • Author(s)
      Itoh, T., Tokunaga, K., Radhakrishnan, E.K., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
    • Journal Title

      ChemBioChem

      Volume: 13(in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase2011

    • Author(s)
      Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Issue: 33 Pages: 13504-13509

    • DOI

      10.1073/pnas.1107782108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase2011

    • Author(s)
      Wakimoto, T., Mori, T., Morita, H., Abe, I.
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 Issue: 13 Pages: 4746-4749

    • DOI

      10.1021/ja2006737

    • NAID

      10029237041

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus2011

    • Author(s)
      Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Issue: 42 Pages: 17533-17537

    • DOI

      10.1073/pnas.1110577108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray analysis of 4-coumarate : CoA ligase from Arabidopsis thaliana2011

    • Author(s)
      Morita, H., Mori, T., Wanibuchi, K., Kato, R., Sugio, S., Abe, I.
    • Journal Title

      Acta Crystallogr., Sect.F : Struct.Biol.Cryst.Commun.

      Volume: 67 Issue: 3 Pages: 409-411

    • DOI

      10.1107/s1744309111002181

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic formation of an aromatic dodecaketide by engineered plant polyketide synthase2011

    • Author(s)
      Wanibuchi, K., Morita, H., Noguchi, H., Abe, I.
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 21 Issue: 7 Pages: 2083-2086

    • DOI

      10.1016/j.bmcl.2011.01.135

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning, modeling and site-directed mutagenesis of type III polyketide synthase from Sargassum binderi2011

    • Author(s)
      Baharum, H., Morita, H., Tomitsuka, A., Lee, F.-C., Ng, K.-Y., Rahim, R.A., Abe, I., Ho, C.-L.
    • Journal Title

      Marine Biotech.

      Volume: 13 Issue: 5 Pages: 845-856

    • DOI

      10.1007/s10126-010-9344-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic Tetramic Acid Derivative Produced by a Plant Type-III Polyketide Synthase2011

    • Author(s)
      T.Wakimoto, T.Mori, H.Morita, I.Abe
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133(In press(掲載確定))

    • NAID

      10029237041

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-Based Engineering of Aloe arborescens Octaketide Synthase2011

    • Author(s)
      K.Wanibuchi, H.Morita, H.Noguchi, I.Abe
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 21 Pages: 2083-2086

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis for The One-pot Formation of The Diarylheptanoid Scaffold by Curcuminoid Synthase from Oryza sativa2010

    • Author(s)
      H.Morita, K.Wanibuchi, H.Nii, R.Kato, S.Sugio, I.Abe
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 19778-19783

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Structure-Based Mechanism for Benzalacetone Synthase from Rheum palmatum2010

    • Author(s)
      H.Morita, Y.Shimokawa, M.Tanio, R.Kato, H.Noguchi, S.Sugio, T.Kohno, I.Abe
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 669-673

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-Based Engineering of Benzalacetone Synthase2010

    • Author(s)
      H.Morita, K.Wanibuchi, R.Kato, S.Sugio, I.Abe
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 5099-5103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 複雑骨格天然物の生合成マシナリーの解明2015

    • Author(s)
      阿部郁朗
    • Organizer
      日本化学会 第95春季年会 イブニングセッション
    • Place of Presentation
      千葉県船橋市
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2014

    • Author(s)
      阿部郁朗
    • Organizer
      2014 Fall Annual Convention of Pharmaceutical Society of Korea
    • Place of Presentation
      Gyeongju, Korea
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 天然物の生合成工学2014

    • Author(s)
      阿部郁朗
    • Organizer
      第49回天然物化学談話会
    • Place of Presentation
      岡山県倉敷市
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Biosynthesis of Fungal Meroterpenoids2014

    • Author(s)
      阿部郁朗
    • Organizer
      97th Canadian Chemistry Conference and Exhibition
    • Place of Presentation
      Vancouver, British Columbia, Canada
    • Year and Date
      2014-06-01 – 2014-06-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2014

    • Author(s)
      阿部郁朗
    • Organizer
      9th International Symposium on Chromatography of Natural Products
    • Place of Presentation
      Medical University of Lublin, Lublin, POLAND
    • Year and Date
      2014-05-26 – 2014-05-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] メロテルペノイド生合成マシナリーの解明と制御2014

    • Author(s)
      阿部郁朗
    • Organizer
      日本薬学会 第134回年会(熊本)シンポジウム 「天然物化学の新潮流と将来への展望」
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] メロテルペノイド生合成マシナリーの解明と制御2014

    • Author(s)
      阿部郁朗
    • Organizer
      日本化学会第94春期年会特別企画「バイオインフォマティクスを駆使した生物活性天然物の供給への挑戦」
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Plant Polyphenols2013

    • Author(s)
      Abe, I.
    • Organizer
      Banbury Conference on Evolution of Plant Metabolic Diversity
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2013-03-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Biosynthesis of fungal meroterpenoids2013

    • Author(s)
      Abe, I.
    • Organizer
      TERPNET2013, Biosynthesis, Function and Biotechnology of Isoprenoids in Terrestrial and Marine Organisms
    • Place of Presentation
      Kolymvari, Crete, Greece
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expanding the catalytic repertoires of biosynthetic enzymes2013

    • Author(s)
      Abe, I.
    • Organizer
      Enzyme Engineering XXII: Emerging topics in Enzyme Engineering
    • Place of Presentation
      富山県富山市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Engineered biosynthesis of medicinal natural products2013

    • Author(s)
      Abe, I.
    • Organizer
      8. International Conference on Medicinal Chemistry and Timmerman Award 2013
    • Place of Presentation
      Jakarta, Indonesia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Plant Polyphenols2012

    • Author(s)
      Abe, I.
    • Organizer
      International Seminar on Natural Product Medicines
    • Place of Presentation
      Bandung, Indonesia
    • Year and Date
      2012-11-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Expanding the Catalytic Repertoires of Biosynthetic Enzymes2012

    • Author(s)
      Abe, I.
    • Organizer
      Directing Biosynthesis III
    • Place of Presentation
      Nottingham, UK
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Engineering Plant Polyketide Synthases2012

    • Author(s)
      Abe, I.
    • Organizer
      The International Conference of Natural Product Biosynthesis (8th US-Japan Seminar)
    • Place of Presentation
      Awajishima, Japan
    • Year and Date
      2012-06-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 二次代謝酵素の機能制御2012

    • Author(s)
      阿部郁朗
    • Organizer
      第132回日本薬学会年会シンポジウム「酵素は何をしているのか?最新科学が解き明かす新機構」
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二次代謝酵素の潜在的触媒能力と機能制御2011

    • Author(s)
      阿部郁朗
    • Organizer
      文部科学省科学研究費補助金「新学術領域研究」生合成マシナリー第1回公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-01-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Engineering Plant Polykedite Synthases2011

    • Author(s)
      Abe, I.
    • Organizer
      Enzyme Engineering XXI
    • Place of Presentation
      Veil, Colorado, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Engineering Plant Polykedite Synthases2011

    • Author(s)
      Abe, I.
    • Organizer
      Phytochemical Society of North America 50^<th> Anniversary Symposium
    • Place of Presentation
      Kohala Coast, Hawaii, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然薬物の生合成工学2010

    • Author(s)
      阿部郁朗
    • Organizer
      徳島文理大学文部科学省戦略的研究基盤形成支援事業研究報告会
    • Place of Presentation
      徳島
    • Year and Date
      2010-12-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Engineering of Plant Polyketide Synthases2010

    • Author(s)
      I.Abe
    • Organizer
      International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Engineering Natural Products Biosynthesis2010

    • Author(s)
      I.Abe
    • Organizer
      9th NRCT-JSPS Joint Seminar
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 植物二次代謝酵素の潜在的触媒能力と機能拡張2010

    • Author(s)
      阿部郁朗
    • Organizer
      第47回 植物化学シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Engineering Natural Products Biosynthesis2010

    • Author(s)
      I.Abe
    • Organizer
      25th Symposium on Natural Products
    • Place of Presentation
      Kaoshung, Taiwan
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 植物ポリケタイド合成酵素の酵素工学2010

    • Author(s)
      阿部郁朗
    • Organizer
      第14回 生体触媒化学シンポジウム「酵素工学と生体触媒化学」
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Engineering of Plant Polyketide Synthases2010

    • Author(s)
      I.Abe
    • Organizer
      Directing Biosynthesis 2010 : Discovery, Evolution, Function
    • Place of Presentation
      Durham, United Kingdom
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Engineering of Plant Polyketide Synthases2010

    • Author(s)
      I.Abe
    • Organizer
      50th Anniversary symposium of the Korean Society for Applied Biological Chemistry
    • Place of Presentation
      Gyeongju, Korea
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Book] Natural Products: Discourse, Diversity and Design (分担執筆)2014

    • Author(s)
      Abe, I.
    • Total Pages
      300
    • Publisher
      Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites (分担執筆)2014

    • Author(s)
      Abe, I., Matsuda, Y.
    • Total Pages
      300
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科天然物化学教室ホームページ

    • URL

      http://www.f.u-tokyo.ac.jp/~tennen/head.htm

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科天然物化学教室

    • URL

      http://www.f.u-tokyo.ac.jp/~tennen/head.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科天然物化学教室

    • URL

      http://www.f.u-tokyo.ac.jp/~tennen/head.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~tennen/head.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~tennen/head.htm

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 植物ポリケタイド合成酵素を用いた3環性非天然型アルカロイドの生産2010

    • Inventor(s)
      阿部郁朗、脇本敏幸、森田洋行、山下誠
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2010-212208
    • Filing Date
      2010-09-22
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi