| Budget Amount *help |
¥39,520,000 (Direct Cost: ¥30,400,000、Indirect Cost: ¥9,120,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
Actinomycetes produce various medically important secondary metabolites such as antibiotics, anticancer drugs, etc. Recent genome analyses revealed that their ability to produce such metabolites was 10-fold higher than previously known. To unveil their hidden ability, we searched for Pfam domains in all proteins coded in four well-annotated actinomycete genomes. The result indicated that there were Pfam domains only or frequently found in secondary metabolism related proteins. We developed a web tool, 2ndFind, to find secondary metabolite biosynthetic genes using those Pfam domains as the indicator. The 2ndFind is freely available at the URL http://biosyn.nih.go.jp/2ndfind/.
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