| Budget Amount *help |
¥110,240,000 (Direct Cost: ¥84,800,000、Indirect Cost: ¥25,440,000)
Fiscal Year 2014: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2013: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2011: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
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| Outline of Final Research Achievements |
Massive deposition of amyloid β peptide (Aβ) as senile plaques is the pathological hallmark of Alzheimer disease (AD), although the mechanism of Aβ deposition remains unclear. In this study, we examined whether synaptic activity influences Aβ secretion and deposition in vivo. Optogenetics is a state-of-the-art technique that enables the selective control of a specific population of neurons by light. We adopted optogenetics and chronically stimulated the perforant pathway, a major input into the hippocampus, of AD model mice, and found a significant increase in Aβ deposition at the projection area of the perforant pathway. These findings implicate functional abnormalities of specific neuronal circuitry in Aβ pathology and AD.
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