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Elucidation of molecular pathogenesis in motor neurocircuit degeneration and development of therapy for motor neuron diseases

Planned Research

Project AreaGeneration of synapse-neurocircuit pathology
Project/Area Number 22110005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

KATSUNO Masahisa  名古屋大学, 医学(系)研究科(研究院), 准教授 (50402566)

Co-Investigator(Kenkyū-buntansha) SOBUE Gen  名古屋大学, 医学系研究科, 教授 (20148315)
ADACHI Hiroaki  名古屋大学, 医学系研究科, COE特任講師 (40432257)
鈴木 啓介  名古屋大学, 医学(系)研究科(研究院), 特任助教 (70635408)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥93,340,000 (Direct Cost: ¥71,800,000、Indirect Cost: ¥21,540,000)
Fiscal Year 2014: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2013: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2011: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Keywords神経変性疾患 / 運動ニューロン / 筋萎縮性側索硬化症 / 球脊髄性筋萎縮症 / 骨格筋 / 酸化ストレス / ミトコンドリア / 細胞周期 / TGF-beta / 熱ショック蛋白質 / heat shock factor-1 / ポリグルタミン / レンチウイルスベクター / サーキット変性 / TGF-β / サイクリン依存性キナーゼ / アンドロゲン受容体 / 筋萎縮性側索硬化 / 運動ニューロン疾患 / CGRP-1 / 神経変性
Outline of Final Research Achievements

We investigated the pathomechanism for adult-onset motor neuron diseases: amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA), and identified HSF-1, TGF-beta, CGRP1, and PPARgamma, as common pathigenic molecules for these disorders. We also clarified that compounds that restore the function of these molecules ameliorate motor neuron degeneration in animal models of ALS and SBA.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (63 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (31 results) (of which Peer Reviewed: 30 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (32 results) (of which Invited: 5 results)

  • [Journal Article] Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.2015

    • Author(s)
      Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G
    • Journal Title

      Hum Mol Genet.

      Volume: 24 Issue: 2 Pages: 314-329

    • DOI

      10.1093/hmg/ddu445

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy.2014

    • Author(s)
      Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G.
    • Journal Title

      Hum Mol Genet.

      Volume: 23 Issue: 13 Pages: 3552-3565

    • DOI

      10.1093/hmg/ddu066

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis.2014

    • Author(s)
      Riku Y, Watanabe H, Yoshida M, Tatsumi S, Mimuro M, Iwasaki Y, Katsuno M, Iguchi Y, Masuda M, Senda J, Ishigaki S, Udagawa T, Sobue G
    • Journal Title

      JAMA Neurol.

      Volume: 71 Issue: 2 Pages: 172-179

    • DOI

      10.1001/jamaneurol.2013.5489

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brugada syndrome in spinal and bulbar muscular atrophy.2014

    • Author(s)
      Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y, Nakatsuji H, Watanabe H, Yamamoto M, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G
    • Journal Title

      Neurology

      Volume: 82 Issue: 20 Pages: 1813-1821

    • DOI

      10.1212/wnl.0000000000000434

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anti-androgen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy2014

    • Author(s)
      Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL
    • Journal Title

      Endocrinology.

      Volume: 155 Issue: 7 Pages: 2624-2634

    • DOI

      10.1210/en.2013-1756

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.2014

    • Author(s)
      Suga N, Katsuno M, Koike H, Banno H, Suzuki K, Hashizume A, Mano T, Iijima M, Kawagashira Y, Hirayama M, Nakamura T, Watanabe H, Tanaka F, Sobue G
    • Journal Title

      Neuropathol Appl Neurobiol.

      Volume: 40 Issue: 5 Pages: 628-639

    • DOI

      10.1111/nan.12055

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy (SBMA)2014

    • Author(s)
      Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Watanabe H, Tanaka S, Yamamoto M, Sobue G
    • Journal Title

      Neurology

      Volume: 82 Issue: 3 Pages: 255-262

    • DOI

      10.1212/wnl.0000000000000041

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy2014

    • Author(s)
      Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP
    • Journal Title

      Hum Mol Genet

      Volume: (Epub ahead of print) Issue: 5 Pages: 1376-1386

    • DOI

      10.1093/hmg/ddt527

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm.2013

    • Author(s)
      Tanaka S, Banno H, Katsuno M, Suzuki K, Suga N, Hashizume A, Mano T, Araki A, Watanabe H, Adachi H, Tatsumi H, Yamamoto M, Sobue G.
    • Journal Title

      J Neurol Sci.

      Volume: 337 Issue: 1-2 Pages: 193-200

    • DOI

      10.1016/j.jns.2013.12.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.2013

    • Author(s)
      Takagi S, Iguchi Y, Katsuno M, Ishigaki S, Ikenaka K, Fujioka Y, Honda D, Niwa J, Tanaka F, Watanabe H, Adachi H, Sobue G.
    • Journal Title

      PLoS One.

      Volume: 28 Issue: 6 Pages: e66966-e66966

    • DOI

      10.1371/journal.pone.0066966

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.2013

    • Author(s)
      Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.
    • Journal Title

      Nat Commun.

      Volume: 4 Issue: 1 Pages: 1816-1816

    • DOI

      10.1038/ncomms2828

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model2013

    • Author(s)
      Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, IidaM,Tohnai G, Qiang Q, Tanaka F, Yanagawa T, WarabiE,Ishii T, Sobue G
    • Journal Title

      J Neurosci

      Volume: 33 Issue: 18 Pages: 7710-7727

    • DOI

      10.1523/jneurosci.3021-12.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration2013

    • Author(s)
      Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G
    • Journal Title

      Nat Commun

      Volume: 4 Issue: 1 Pages: 1405-1405

    • DOI

      10.1038/ncomms2417

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of TDP-43 causes age-dependent progressive motor neuron degeneration2013

    • Author(s)
      Iguchi Y
    • Journal Title

      Brain

      Volume: 136 Issue: 5 Pages: 1371-1382

    • DOI

      10.1093/brain/awt029

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration2013

    • Author(s)
      Ikenaka K
    • Journal Title

      PLoS One

      Volume: 8 Issue: 2 Pages: e54511-e54511

    • DOI

      10.1371/journal.pone.0054511

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis2012

    • Author(s)
      Katsumata R
    • Journal Title

      PLoS One

      Volume: 7 Issue: 9 Pages: e46185-e46185

    • DOI

      10.1371/journal.pone.0046185

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals.2012

    • Author(s)
      Sahashi K, Hua Y, Ling KK, Hung G, Rigo F, Horev G, Katsuno M, Sobue G, Ko CP, Bennett CF, Krainer AR.
    • Journal Title

      Genes Dev.

      Volume: 26 Issue: 16 Pages: 1874-1884

    • DOI

      10.1101/gad.197418.112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.2012

    • Author(s)
      Ishigaki S, Masuda A, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K
    • Journal Title

      Sci Rep

      Volume: 2 Issue: 1 Pages: 529-529

    • DOI

      10.1038/srep00529

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseases2012

    • Author(s)
      Katsuno M, Tanaka F, Sobue G
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83 Issue: 3 Pages: 329-335

    • DOI

      10.1136/jnnp-2011-301307

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective axonal transport in motor neuron diseases.2012

    • Author(s)
      Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G.
    • Journal Title

      Int J Mol Sci.

      Volume: 13 Issue: 1 Pages: 1225-1238

    • DOI

      10.3390/ijms13011225

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials.2012

    • Author(s)
      Hama T, Hirayama M, Hara T, Nakamura T, Atsuta N, Banno H, Suzuki K, Katsuno M, Tanaka F, Sobue G.
    • Journal Title

      Muscle Nerve

      Volume: 45 Issue: 2 Pages: 169-174

    • DOI

      10.1002/mus.22291

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.2012

    • Author(s)
      Iguchi Y,Katsuno M,Takagi S.Ishigaki S,Niwa JI,Hasegawa M,Tanaka F,Sobue G
    • Journal Title

      Neurobiol Dis

      Volume: 45 Issue: 3 Pages: 862-870

    • DOI

      10.1016/j.nbd.2011.12.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential change of clinical outcome measures in spinal and bulbar muscular atrophy: comparison of natural history with placebo-treated group.2012

    • Author(s)
      Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G.
    • Journal Title

      J Neurol.

      Volume: 259 Issue: 4 Pages: 712-719

    • DOI

      10.1007/s00415-011-6251-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pathophysiology and disease-Modifying therapies for spinal and bulbar muscular atrophy2012

    • Author(s)
      Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
    • Journal Title

      Arch Neurol

      Volume: 69 Issue: 4 Pages: 436-440

    • DOI

      10.1001/archneurol.2011.2308

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese.2011

    • Author(s)
      Iida A
    • Journal Title

      Hum Mol Genet

      Volume: 20 Issue: 18 Pages: 3684-3692

    • DOI

      10.1093/hmg/ddr268

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microarray analysis of gene expression by skeletal muscle of three mouse models of kennedy disease/spinal bulbar muscular atrophy.2010

    • Author(s)
      Mo K, Razak Z, Rao P, Yu Z, Adachi H, Katsuno M, Sobue G, Lieberman AP, Westwood JT, Monks DA.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study) : a multicentre, randomised, double-blind, placebo-controlled trial.2010

    • Author(s)
      Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue G ; for the Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group.
    • Journal Title

      Lancet Neurol.

      Volume: 9 Pages: 875-884

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy.2010

    • Author(s)
      Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G.
    • Journal Title

      J Neurosci.

      Volume: 30 Pages: 5702-5707

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy.2010

    • Author(s)
      Suzuki K, Katsuno M, Banno H, Takeuchi Y, Kawashima M, Suga N, Hashizume A, Hama T, Uchida K, Yamashita F, Nakamura T, Hirayama M, Tanaka F, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 81 Pages: 567-571

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dutasteride for spinal and bulbar muscular atrophy : another advance to wards disease-modifying therapy.2010

    • Author(s)
      Banno H, Katsuno M, Suzuki K, Sobue G.
    • Journal Title

      Lancet Neurol.

      Volume: 10 Pages: 113-115

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Transforming growth factor-beta signaling in motor neuron diseases.2010

    • Author(s)
      Katsuno M, Adachi H, Banno H, Suzuki K, Tanaka F, Sobue G.
    • Journal Title

      Current Mol Med.

      Volume: 11 Pages: 48-56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The involvement of glial cells in FUS-related ALS/FTLD pathophysiology -FUS knock-down glial cells have a neuro-protective effect.2014

    • Author(s)
      Fujioka Y, Ishigaki S, Shiromizu T,, Udagawa T, Honda D, Yokoi S, Ikenaka K, Katsuno M, Tomonaga T, Sobue G
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Androgen-dependent deficits in muscle-derived BDNF correlate with motor dysfunction in two mouse models of spinal bulbar muscular atrophy.2014

    • Author(s)
      Halievski K, Xu Y, Henley CL, Katsuno M, Adachi H, Sobue G, Breedlove S, Jordan CL.
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] SBMA motor dysfunction may be due to failed neuromuscular transmission.2014

    • Author(s)
      Xu, Atchison W, Adachi H, Katsuno M, Sobue G, Breedlove S, Jordan CL.
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] The blood-spinal cord barrier is temporarily impaired in TDP-43 conditional knockout mice.2014

    • Author(s)
      Sasaki S, Iguchi Y, Katsuno M, Sobue G
    • Organizer
      The 13th International Congress on Neuromuscular Diseases.
    • Place of Presentation
      Nice, France
    • Year and Date
      2014-07-05 – 2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経変性疾患に対する医師主導治験.2014

    • Author(s)
      勝野雅央.
    • Organizer
      第11回医薬品評価フォーラム
    • Place of Presentation
      東京都渋谷区日本薬学会 長井記念館
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular pathway and therapeutic strategies for motor neuron diseases.2014

    • Author(s)
      Katsuno M.
    • Organizer
      The 5th East Asia Neurology Forum (EANF)
    • Place of Presentation
      Kaoshiung, Taiwan
    • Year and Date
      2014-04-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Pathogenesis of selective neurodegeneration in polyglutamine-mediated motor neuron disease.2014

    • Author(s)
      Katsuno, M., Sobue, G.
    • Organizer
      New Frontier of Molecular Neuropathology 2014
    • Place of Presentation
      東京大学本郷キャンパス 伊藤国際学術研究センター、東京都文京区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Deficits in brain-derived neurotrophic factor may underlie motor dysfunction in spinal bulbar muscular atrophy.2013

    • Author(s)
      Hlievski, K., Henley, C.L., Fu, M., Katsuno, M., Adachi, H., Sobue, G., Breedlove, S.M., Jordan, C.L.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease.2013

    • Author(s)
      Adachi, H., Qiang, Q., Hunag, Z., Jinag, Y.M., Katsuno, M., Kondo, N., Miyazaki, Y., Iida, M., Tohnai, G., Nakatsuji, H., Sobue, G.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heat shock factor-1 (Hsf-1) controls pathological lesion distribution of polyglutamine-induced motor neuron disease.2013

    • Author(s)
      Kondo, N., Katsuno, M., Adachi, H., Minamiyama, M., Matsumoto, S., Nakatsuji, H., Miyazaki, Y., Iida, M., Tohnai, G., Sobue, G.
    • Organizer
      The 24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Loss of TDP-43 Results In Age-dependent Progressive Motor Impairment And Neuropathological Alterations, Mimicking Motor Neuron Disease.2012

    • Author(s)
      Iguchi Y, Katsuno M, Niwa JI, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Sobue G.
    • Organizer
      24th ALS/MND international symposium.
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-12-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Comparison of Fus-regulating gene expression and alternative splicing profiles among different cell lineages in the central nervous system.2012

    • Author(s)
      Ishigaki S, Fujioka Y, Masuda A, Iguchi Y, Katsuno M, Ohno K, Sobue G.
    • Organizer
      42nd Society for Neuroscience annual meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 運動ニューロンの老化と変性.2012

    • Author(s)
      勝野雅央.
    • Organizer
      第34回日本生物学的精神医学会シンポジウム『老いを科学する―神経変性の視点から』
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2012-09-29
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Elucidation of neuronal death signaling pathways and development of disease-modifying therapies for Kennedy's disease2011

    • Author(s)
      Katsuno, M.
    • Organizer
      Kennedy's Disease Association 2011 Annual Conference and Education Symposium
    • Place of Presentation
      Bowie, USA(招待)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] TGF-betaからみた神経変性機序2011

    • Author(s)
      勝野雅央
    • Organizer
      第52回日本神経学会学術大会シンポジウム
    • Place of Presentation
      名古屋(招待)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of leuprorelin in patients with spinal and bulbar muscular atrophy (SBMA) : a multicenter, randomized, double-blind, placebo-controlled trial2011

    • Author(s)
      Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue G; for the Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group
    • Organizer
      63rd American Academy of Neurology Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Long-term effects of the luteinizing hormone-releasing hormone analogues for spinal and bulbar muscular atrophy2011

    • Author(s)
      Ota K, Ishikawa K, Suzuki K, Banno H, Katsuno M, Sobue G, Mizusawa H
    • Organizer
      63rd American Academy of Neurology Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Central motor conduction time (CMCT) in patients with spinal and bulbar muscular atrophy (SBMA)2011

    • Author(s)
      Suzuki K, Katsuno M, Banno H, Suga N, Hashizume A, Hara T, Hama T, Nakamura T, Hirayama M, Tanaka F, Sobue G
    • Organizer
      15th Congress of the European Federation of Neurological Societies
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA)2011

    • Author(s)
      Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
    • Organizer
      Gordon conference on CAG triplet repeat disorders
    • Place of Presentation
      Il Ciocco, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] Heat shock factor-1 (Hsf-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA)2011

    • Author(s)
      Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
    • Organizer
      Gordon conference on CAG triplet repeat disorders
    • Place of Presentation
      Il Ciocco, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] 球脊髄性筋萎縮症における細胞周期異常2011

    • Author(s)
      勝野雅央, 足立弘明, 南山誠, 土井英樹, 近藤直英, 松本慎二郎, 宮崎雄, 坂野晴彦, 鈴木啓介, 田中章景, 祖父江元
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 球脊髄性筋萎縮症モデルマウスにおける異常蛋白凝集の病理学的分布はHsf-1の影響を受ける2011

    • Author(s)
      近藤直英, 勝野雅央, 足立弘明, 南山誠, 土井英樹, 松本慎二郎, 宮崎雄, 飯田円, 田中章景, 祖父江元
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 球脊髄性筋萎縮症(SBMA)病態関連遺伝子CGRP1の分子機構2011

    • Author(s)
      南山誠, 勝野雅央, 足立弘明, 土井英樹, 近藤直英, 田中章景, 祖父江元, 栗原裕基.
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA)2011

    • Author(s)
      Katsuno M, Adachi H, Minamiyama M, Kondo N, Doi H, Matsumoto S, Miyazaki Y, Tanaka F, Sobue G
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular pathology of SBMA (Spinal Bulbar Muscular Atrophy) related gene CGRP12011

    • Author(s)
      Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Tanaka F, Sobue G, Kurihara H
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Heat shock factor-1 (HSF-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA)2011

    • Author(s)
      Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tanaka F, Sobue G
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 球脊髄性筋萎縮症に対する臨床治験の取組2010

    • Author(s)
      勝野雅央
    • Organizer
      平成22年度厚生労働科学研究費補助金(難治性疾患克服研究事業)「今後の難病対策に関する研究」シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy.2010

    • Author(s)
      Katsuno M, Adachi H, Minamiyama M, Doi H, Kondo N, Matsumoto S, Miyazaki Y, Banno H, Suzuki K, Tanaka F, Sobue G.
    • Organizer
      21st International Symposium on ALS/MND.
    • Place of Presentation
      Orlando, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] A peony extract alleviates polyglutamine-mediated motor neuron disease.2010

    • Author(s)
      Adachi H, Tohnai G, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Tanaka F, Sobue G.
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oxidative stress induces TDP-43 modification, recapitulating its pathological feature.2010

    • Author(s)
      Iguchi Y, Katsuno M, Takagi S, Sobue G.
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 球脊髄性筋萎縮症(SBMA)におけるナトリウムチャンネルの発現異常2010

    • Author(s)
      勝野雅央、足立弘明、南山誠、土井英樹、近藤直英、松本慎二郎、坂野晴彦、鈴木啓介、田中章景、祖父江元
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neurobiological Study of Postmortem Brain from Brain Bank: for the study of spinal disorders.

    • Author(s)
      Katsuno M.
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館、京都市
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2010-08-23   Modified: 2019-07-29  

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