Elucidation of molecular pathogenesis in motor neurocircuit degeneration and development of therapy for motor neuron diseases

• Project Area: Generation of synapse-neurocircuit pathology
• Project/Area Number: 22110005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: KATSUNO Masahisa 名古屋大学, 医学(系)研究科(研究院), 准教授 (50402566)
• Co-Investigator(Kenkyū-buntansha): SOBUE Gen 名古屋大学, 医学系研究科, 教授 (20148315) ; ADACHI Hiroaki 名古屋大学, 医学系研究科, COE特任講師 (40432257) ; 鈴木 啓介 名古屋大学, 医学(系)研究科(研究院), 特任助教 (70635408)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥93,340,000 (Direct Cost: ¥71,800,000、Indirect Cost: ¥21,540,000); Fiscal Year 2014: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2013: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2011: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
• Keywords: 神経変性疾患 / 運動ニューロン / 筋萎縮性側索硬化症 / 球脊髄性筋萎縮症 / 骨格筋 / 酸化ストレス / ミトコンドリア / 細胞周期 / TGF-beta / 熱ショック蛋白質 / heat shock factor-1 / ポリグルタミン / レンチウイルスベクター / サーキット変性 / TGF-β / サイクリン依存性キナーゼ / アンドロゲン受容体 / 筋萎縮性側索硬化 / 運動ニューロン疾患 / CGRP-1 / 神経変性

Outline of Final Research Achievements

We investigated the pathomechanism for adult-onset motor neuron diseases: amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA), and identified HSF-1, TGF-beta, CGRP1, and PPARgamma, as common pathigenic molecules for these disorders. We also clarified that compounds that restore the function of these molecules ameliorate motor neuron degeneration in animal models of ALS and SBA.

Research Products

• [Journal Article] Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors. (2015)
  • Author(s): Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G
  • Journal Title: Hum Mol Genet. Volume: 24 Issue: 2 Pages: 314-329
  • DOI: 10.1093/hmg/ddu445
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy. (2014)
  • Author(s): Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G.
  • Journal Title: Hum Mol Genet. Volume: 23 Issue: 13 Pages: 3552-3565
  • DOI: 10.1093/hmg/ddu066
  • Peer Reviewed / Open Access
• [Journal Article] Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (2014)
  • Author(s): Riku Y, Watanabe H, Yoshida M, Tatsumi S, Mimuro M, Iwasaki Y, Katsuno M, Iguchi Y, Masuda M, Senda J, Ishigaki S, Udagawa T, Sobue G
  • Journal Title: JAMA Neurol. Volume: 71 Issue: 2 Pages: 172-179
  • DOI: 10.1001/jamaneurol.2013.5489
  • Peer Reviewed
• [Journal Article] Brugada syndrome in spinal and bulbar muscular atrophy. (2014)
  • Author(s): Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y, Nakatsuji H, Watanabe H, Yamamoto M, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G
  • Journal Title: Neurology Volume: 82 Issue: 20 Pages: 1813-1821
  • DOI: 10.1212/wnl.0000000000000434
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anti-androgen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy (2014)
  • Author(s): Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL
  • Journal Title: Endocrinology. Volume: 155 Issue: 7 Pages: 2624-2634
  • DOI: 10.1210/en.2013-1756
  • Peer Reviewed
• [Journal Article] Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3. (2014)
  • Author(s): Suga N, Katsuno M, Koike H, Banno H, Suzuki K, Hashizume A, Mano T, Iijima M, Kawagashira Y, Hirayama M, Nakamura T, Watanabe H, Tanaka F, Sobue G
  • Journal Title: Neuropathol Appl Neurobiol. Volume: 40 Issue: 5 Pages: 628-639
  • DOI: 10.1111/nan.12055
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy (SBMA) (2014)
  • Author(s): Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Watanabe H, Tanaka S, Yamamoto M, Sobue G
  • Journal Title: Neurology Volume: 82 Issue: 3 Pages: 255-262
  • DOI: 10.1212/wnl.0000000000000041
  • Peer Reviewed
• [Journal Article] Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy (2014)
  • Author(s): Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP
  • Journal Title: Hum Mol Genet Volume: (Epub ahead of print) Issue: 5 Pages: 1376-1386
  • DOI: 10.1093/hmg/ddt527
  • Peer Reviewed
• [Journal Article] Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm. (2013)
  • Author(s): Tanaka S, Banno H, Katsuno M, Suzuki K, Suga N, Hashizume A, Mano T, Araki A, Watanabe H, Adachi H, Tatsumi H, Yamamoto M, Sobue G.
  • Journal Title: J Neurol Sci. Volume: 337 Issue: 1-2 Pages: 193-200
  • DOI: 10.1016/j.jns.2013.12.010
  • Peer Reviewed
• [Journal Article] RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43. (2013)
  • Author(s): Takagi S, Iguchi Y, Katsuno M, Ishigaki S, Ikenaka K, Fujioka Y, Honda D, Niwa J, Tanaka F, Watanabe H, Adachi H, Sobue G.
  • Journal Title: PLoS One. Volume: 28 Issue: 6 Pages: e66966-e66966
  • DOI: 10.1371/journal.pone.0066966
  • Peer Reviewed
• [Journal Article] A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. (2013)
  • Author(s): Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 1816-1816
  • DOI: 10.1038/ncomms2828
  • Peer Reviewed
• [Journal Article] p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model (2013)
  • Author(s): Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, IidaM,Tohnai G, Qiang Q, Tanaka F, Yanagawa T, WarabiE,Ishii T, Sobue G
  • Journal Title: J Neurosci Volume: 33 Issue: 18 Pages: 7710-7727
  • DOI: 10.1523/jneurosci.3021-12.2013
  • Peer Reviewed
• [Journal Article] Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration (2013)
  • Author(s): Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G
  • Journal Title: Nat Commun Volume: 4 Issue: 1 Pages: 1405-1405
  • DOI: 10.1038/ncomms2417
  • Peer Reviewed
• [Journal Article] Loss of TDP-43 causes age-dependent progressive motor neuron degeneration (2013)
  • Author(s): Iguchi Y
  • Journal Title: Brain Volume: 136 Issue: 5 Pages: 1371-1382
  • DOI: 10.1093/brain/awt029
  • Peer Reviewed / Open Access
• [Journal Article] dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration (2013)
  • Author(s): Ikenaka K
  • Journal Title: PLoS One Volume: 8 Issue: 2 Pages: e54511-e54511
  • DOI: 10.1371/journal.pone.0054511
  • Peer Reviewed
• [Journal Article] c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis (2012)
  • Author(s): Katsumata R
  • Journal Title: PLoS One Volume: 7 Issue: 9 Pages: e46185-e46185
  • DOI: 10.1371/journal.pone.0046185
  • Peer Reviewed
• [Journal Article] TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals. (2012)
  • Author(s): Sahashi K, Hua Y, Ling KK, Hung G, Rigo F, Horev G, Katsuno M, Sobue G, Ko CP, Bennett CF, Krainer AR.
  • Journal Title: Genes Dev. Volume: 26 Issue: 16 Pages: 1874-1884
  • DOI: 10.1101/gad.197418.112
  • Peer Reviewed
• [Journal Article] Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. (2012)
  • Author(s): Ishigaki S, Masuda A, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K
  • Journal Title: Sci Rep Volume: 2 Issue: 1 Pages: 529-529
  • DOI: 10.1038/srep00529
  • Peer Reviewed
• [Journal Article] Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseases (2012)
  • Author(s): Katsuno M, Tanaka F, Sobue G
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 83 Issue: 3 Pages: 329-335
  • DOI: 10.1136/jnnp-2011-301307
  • Peer Reviewed
• [Journal Article] Defective axonal transport in motor neuron diseases. (2012)
  • Author(s): Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G.
  • Journal Title: Int J Mol Sci. Volume: 13 Issue: 1 Pages: 1225-1238
  • DOI: 10.3390/ijms13011225
  • Peer Reviewed
• [Journal Article] Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials. (2012)
  • Author(s): Hama T, Hirayama M, Hara T, Nakamura T, Atsuta N, Banno H, Suzuki K, Katsuno M, Tanaka F, Sobue G.
  • Journal Title: Muscle Nerve Volume: 45 Issue: 2 Pages: 169-174
  • DOI: 10.1002/mus.22291
  • Peer Reviewed
• [Journal Article] Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies. (2012)
  • Author(s): Iguchi Y,Katsuno M,Takagi S.Ishigaki S,Niwa JI,Hasegawa M,Tanaka F,Sobue G
  • Journal Title: Neurobiol Dis Volume: 45 Issue: 3 Pages: 862-870
  • DOI: 10.1016/j.nbd.2011.12.002
  • Peer Reviewed
• [Journal Article] Differential change of clinical outcome measures in spinal and bulbar muscular atrophy: comparison of natural history with placebo-treated group. (2012)
  • Author(s): Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G.
  • Journal Title: J Neurol. Volume: 259 Issue: 4 Pages: 712-719
  • DOI: 10.1007/s00415-011-6251-2
  • Peer Reviewed
• [Journal Article] Molecular pathophysiology and disease-Modifying therapies for spinal and bulbar muscular atrophy (2012)
  • Author(s): Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
  • Journal Title: Arch Neurol Volume: 69 Issue: 4 Pages: 436-440
  • DOI: 10.1001/archneurol.2011.2308
  • Peer Reviewed
• [Journal Article] A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. (2011)
  • Author(s): Iida A
  • Journal Title: Hum Mol Genet Volume: 20 Issue: 18 Pages: 3684-3692
  • DOI: 10.1093/hmg/ddr268
  • Peer Reviewed
• [Journal Article] Microarray analysis of gene expression by skeletal muscle of three mouse models of kennedy disease/spinal bulbar muscular atrophy. (2010)
  • Author(s): Mo K, Razak Z, Rao P, Yu Z, Adachi H, Katsuno M, Sobue G, Lieberman AP, Westwood JT, Monks DA.
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study) : a multicentre, randomised, double-blind, placebo-controlled trial. (2010)
  • Author(s): Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue G ; for the Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group.
  • Journal Title: Lancet Neurol. Volume: 9 Pages: 875-884
  • Peer Reviewed
• [Journal Article] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy. (2010)
  • Author(s): Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G.
  • Journal Title: J Neurosci. Volume: 30 Pages: 5702-5707
  • Peer Reviewed
• [Journal Article] The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy. (2010)
  • Author(s): Suzuki K, Katsuno M, Banno H, Takeuchi Y, Kawashima M, Suga N, Hashizume A, Hama T, Uchida K, Yamashita F, Nakamura T, Hirayama M, Tanaka F, Sobue G.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 81 Pages: 567-571
  • Peer Reviewed
• [Journal Article] Dutasteride for spinal and bulbar muscular atrophy : another advance to wards disease-modifying therapy. (2010)
  • Author(s): Banno H, Katsuno M, Suzuki K, Sobue G.
  • Journal Title: Lancet Neurol. Volume: 10 Pages: 113-115
• [Journal Article] Transforming growth factor-beta signaling in motor neuron diseases. (2010)
  • Author(s): Katsuno M, Adachi H, Banno H, Suzuki K, Tanaka F, Sobue G.
  • Journal Title: Current Mol Med. Volume: 11 Pages: 48-56
  • Peer Reviewed
• [Presentation] The involvement of glial cells in FUS-related ALS/FTLD pathophysiology -FUS knock-down glial cells have a neuro-protective effect. (2014)
  • Author(s): Fujioka Y, Ishigaki S, Shiromizu T,, Udagawa T, Honda D, Yokoi S, Ikenaka K, Katsuno M, Tomonaga T, Sobue G
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Androgen-dependent deficits in muscle-derived BDNF correlate with motor dysfunction in two mouse models of spinal bulbar muscular atrophy. (2014)
  • Author(s): Halievski K, Xu Y, Henley CL, Katsuno M, Adachi H, Sobue G, Breedlove S, Jordan CL.
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] SBMA motor dysfunction may be due to failed neuromuscular transmission. (2014)
  • Author(s): Xu, Atchison W, Adachi H, Katsuno M, Sobue G, Breedlove S, Jordan CL.
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] The blood-spinal cord barrier is temporarily impaired in TDP-43 conditional knockout mice. (2014)
  • Author(s): Sasaki S, Iguchi Y, Katsuno M, Sobue G
  • Organizer: The 13th International Congress on Neuromuscular Diseases.
  • Place of Presentation: Nice, France
  • Year and Date: 2014-07-05 – 2014-07-10
• [Presentation] 神経変性疾患に対する医師主導治験. (2014)
  • Author(s): 勝野雅央.
  • Organizer: 第11回医薬品評価フォーラム
  • Place of Presentation: 東京都渋谷区日本薬学会 長井記念館
  • Year and Date: 2014-04-24
  • Invited
• [Presentation] Molecular pathway and therapeutic strategies for motor neuron diseases. (2014)
  • Author(s): Katsuno M.
  • Organizer: The 5th East Asia Neurology Forum (EANF)
  • Place of Presentation: Kaoshiung, Taiwan
  • Year and Date: 2014-04-12
  • Invited
• [Presentation] Pathogenesis of selective neurodegeneration in polyglutamine-mediated motor neuron disease. (2014)
  • Author(s): Katsuno, M., Sobue, G.
  • Organizer: New Frontier of Molecular Neuropathology 2014
  • Place of Presentation: 東京大学本郷キャンパス 伊藤国際学術研究センター、東京都文京区
  • Invited
• [Presentation] Deficits in brain-derived neurotrophic factor may underlie motor dysfunction in spinal bulbar muscular atrophy. (2013)
  • Author(s): Hlievski, K., Henley, C.L., Fu, M., Katsuno, M., Adachi, H., Sobue, G., Breedlove, S.M., Jordan, C.L.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
• [Presentation] Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease. (2013)
  • Author(s): Adachi, H., Qiang, Q., Hunag, Z., Jinag, Y.M., Katsuno, M., Kondo, N., Miyazaki, Y., Iida, M., Tohnai, G., Nakatsuji, H., Sobue, G.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
• [Presentation] Heat shock factor-1 (Hsf-1) controls pathological lesion distribution of polyglutamine-induced motor neuron disease. (2013)
  • Author(s): Kondo, N., Katsuno, M., Adachi, H., Minamiyama, M., Matsumoto, S., Nakatsuji, H., Miyazaki, Y., Iida, M., Tohnai, G., Sobue, G.
  • Organizer: The 24th International Symposium on ALS/MND
  • Place of Presentation: Milan, Italy
• [Presentation] Loss of TDP-43 Results In Age-dependent Progressive Motor Impairment And Neuropathological Alterations, Mimicking Motor Neuron Disease. (2012)
  • Author(s): Iguchi Y, Katsuno M, Niwa JI, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Sobue G.
  • Organizer: 24th ALS/MND international symposium.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2012-12-04
• [Presentation] Comparison of Fus-regulating gene expression and alternative splicing profiles among different cell lineages in the central nervous system. (2012)
  • Author(s): Ishigaki S, Fujioka Y, Masuda A, Iguchi Y, Katsuno M, Ohno K, Sobue G.
  • Organizer: 42nd Society for Neuroscience annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-13
• [Presentation] 運動ニューロンの老化と変性. (2012)
  • Author(s): 勝野雅央.
  • Organizer: 第34回日本生物学的精神医学会シンポジウム『老いを科学する―神経変性の視点から』
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2012-09-29
  • Invited
• [Presentation] Elucidation of neuronal death signaling pathways and development of disease-modifying therapies for Kennedy's disease (2011)
  • Author(s): Katsuno, M.
  • Organizer: Kennedy's Disease Association 2011 Annual Conference and Education Symposium
  • Place of Presentation: Bowie, USA(招待)
  • Year and Date: 2011-11-09
• [Presentation] TGF-betaからみた神経変性機序 (2011)
  • Author(s): 勝野雅央
  • Organizer: 第52回日本神経学会学術大会シンポジウム
  • Place of Presentation: 名古屋(招待)
• [Presentation] Effect of leuprorelin in patients with spinal and bulbar muscular atrophy (SBMA) : a multicenter, randomized, double-blind, placebo-controlled trial (2011)
  • Author(s): Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue G; for the Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group
  • Organizer: 63rd American Academy of Neurology Annual Meeting
  • Place of Presentation: Honolulu, USA
• [Presentation] Long-term effects of the luteinizing hormone-releasing hormone analogues for spinal and bulbar muscular atrophy (2011)
  • Author(s): Ota K, Ishikawa K, Suzuki K, Banno H, Katsuno M, Sobue G, Mizusawa H
  • Organizer: 63rd American Academy of Neurology Annual Meeting
  • Place of Presentation: Honolulu, USA
• [Presentation] Central motor conduction time (CMCT) in patients with spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Suzuki K, Katsuno M, Banno H, Suga N, Hashizume A, Hara T, Hama T, Nakamura T, Hirayama M, Tanaka F, Sobue G
  • Organizer: 15th Congress of the European Federation of Neurological Societies
  • Place of Presentation: Budapest, Hungary
• [Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
  • Organizer: Gordon conference on CAG triplet repeat disorders
  • Place of Presentation: Il Ciocco, Italy
• [Presentation] Heat shock factor-1 (Hsf-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
  • Organizer: Gordon conference on CAG triplet repeat disorders
  • Place of Presentation: Il Ciocco, Italy
• [Presentation] 球脊髄性筋萎縮症における細胞周期異常 (2011)
  • Author(s): 勝野雅央, 足立弘明, 南山誠, 土井英樹, 近藤直英, 松本慎二郎, 宮崎雄, 坂野晴彦, 鈴木啓介, 田中章景, 祖父江元
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 球脊髄性筋萎縮症モデルマウスにおける異常蛋白凝集の病理学的分布はHsf-1の影響を受ける (2011)
  • Author(s): 近藤直英, 勝野雅央, 足立弘明, 南山誠, 土井英樹, 松本慎二郎, 宮崎雄, 飯田円, 田中章景, 祖父江元
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 球脊髄性筋萎縮症(SBMA)病態関連遺伝子CGRP1の分子機構 (2011)
  • Author(s): 南山誠, 勝野雅央, 足立弘明, 土井英樹, 近藤直英, 田中章景, 祖父江元, 栗原裕基.
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Katsuno M, Adachi H, Minamiyama M, Kondo N, Doi H, Matsumoto S, Miyazaki Y, Tanaka F, Sobue G
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Molecular pathology of SBMA (Spinal Bulbar Muscular Atrophy) related gene CGRP1 (2011)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Tanaka F, Sobue G, Kurihara H
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Heat shock factor-1 (HSF-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA) (2011)
  • Author(s): Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tanaka F, Sobue G
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 球脊髄性筋萎縮症に対する臨床治験の取組 (2010)
  • Author(s): 勝野雅央
  • Organizer: 平成22年度厚生労働科学研究費補助金(難治性疾患克服研究事業)「今後の難病対策に関する研究」シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-08-28
• [Presentation] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy. (2010)
  • Author(s): Katsuno M, Adachi H, Minamiyama M, Doi H, Kondo N, Matsumoto S, Miyazaki Y, Banno H, Suzuki K, Tanaka F, Sobue G.
  • Organizer: 21st International Symposium on ALS/MND.
  • Place of Presentation: Orlando, USA
• [Presentation] A peony extract alleviates polyglutamine-mediated motor neuron disease. (2010)
  • Author(s): Adachi H, Tohnai G, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Tanaka F, Sobue G.
  • Organizer: Neuroscience 2010
  • Place of Presentation: San Diego, USA
• [Presentation] Oxidative stress induces TDP-43 modification, recapitulating its pathological feature. (2010)
  • Author(s): Iguchi Y, Katsuno M, Takagi S, Sobue G.
  • Organizer: Neuroscience 2010
  • Place of Presentation: San Diego, USA
• [Presentation] 球脊髄性筋萎縮症(SBMA)におけるナトリウムチャンネルの発現異常 (2010)
  • Author(s): 勝野雅央、足立弘明、南山誠、土井英樹、近藤直英、松本慎二郎、坂野晴彦、鈴木啓介、田中章景、祖父江元
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
• [Presentation] Neurobiological Study of Postmortem Brain from Brain Bank: for the study of spinal disorders.
  • Author(s): Katsuno M.
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館、京都市
  • Invited