| Budget Amount *help |
¥97,240,000 (Direct Cost: ¥74,800,000、Indirect Cost: ¥22,440,000)
Fiscal Year 2014: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2013: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2011: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
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| Outline of Final Research Achievements |
In this research, we aimed to clarify the mechanism by which random cell motility arises spontaneously based on the dynamics of intracellular reaction networks. We found that the Phosphatidylinositol (PtdIns) lipids are self-organized to generate spontaneous signals for random motility. Characteristic oscillatory dynamics within the PtdIns lipids system were determined experimentally and the reaction-diffusion model was developed to reproduce the characteristic oscillatory dynamics. Results show that the self-organization of the PtdIns lipids system provides the noise-robust mechanisms necessary to establish the spontaneous motility. In addition, the molecular noise can give rise to the phenotypic variability and thus be the origin of the spontaneous signals observed in random cellular motility. The model suggests that random cell motility is affected by the molecular noise, and that it contributes to adaptability and a flexible search strategy in a changing and complex environment.
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