| Budget Amount *help |
¥150,280,000 (Direct Cost: ¥115,600,000、Indirect Cost: ¥34,680,000)
Fiscal Year 2014: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2013: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2012: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2010: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
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| Outline of Final Research Achievements |
The migration of gonadal leader cells (DTCs) is regulated by the extracellular matrix (ECM) as well as by their cytoskeleton in C. elegans. In this study, we found that GON-1 (matrix metalloprotease) and fibulin-1 (ECM molecule) act antagonistically to regulate the metabolism of type IV collagen and that VAB-10, a cytoskeletal linker protein, acts in cell and nuclear migration through regulating polarized outgrowth of DTC microtubules. We also showed that MIG-39, a nuclear protein, acts with Rho family GTPases to halt DTC migration.
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