| Co-Investigator(Renkei-kenkyūsha) |
KAWAGUCHI Ayano 名古屋大学, 大学院医学系研究科, 准教授 (90360528)
SAKAKIBARA Akira 名古屋大学大学, 院医学系研究科, 助教 (20510217)
HASHIMOTO Mitsuhiro 名古屋大学, 大学院医学系研究科, 助教 (90311357)
SHINODA Tomoyasu 名古屋大学, 大学院医学系研究科, 助教 (80505652)
OKAMOTO Mayumi 名古屋大学, 大学院医学系研究科, 特任助教 (30551965)
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| Budget Amount *help |
¥190,190,000 (Direct Cost: ¥146,300,000、Indirect Cost: ¥43,890,000)
Fiscal Year 2014: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2013: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2012: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2011: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
Fiscal Year 2010: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
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| Outline of Final Research Achievements |
Belonging to the "Cross-talk between moving cells and microenvironment as a basis of emerging order in multicellular system", this research project studied how movements of neural progenitor cells are coordinated to establish the safe and efficient "neurogenesis" (i.e. production of neurons to build a brain structure) without suffering from a "traffic jam" of cells in a narrow tissue-developing space. Using new techniques such as live imaging of all cells, quantitative analysis on trajectories of moving cells, and mechanical experiments, we found that cells are cleverly moving in a manner similar to "staggered commuting" (i.e. one cell goes first then the other follows). If this "crowd control" method does not work during development, brain structure cannot form normally (Nature Neuroscience, 2013). We further demonstrated brain cells' migration strategy is different between mice and ferret, suggesting that control of cellular movements may underlie brain evolution.
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