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Analysis of malignant progression of cancer cells affected by the tumor microenvironment

Planned Research

Project AreaIntegrative Research on Cancer Microenvironment Network
Project/Area Number 22112005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

TAKAKURA NOBUYUKI  大阪大学, 微生物病研究所, 教授 (80291954)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥180,180,000 (Direct Cost: ¥138,600,000、Indirect Cost: ¥41,580,000)
Fiscal Year 2014: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2013: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Fiscal Year 2012: ¥36,270,000 (Direct Cost: ¥27,900,000、Indirect Cost: ¥8,370,000)
Fiscal Year 2011: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Fiscal Year 2010: ¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Keywords癌 / がん幹細胞 / 血管 / ストロマ細胞 / 血管新生 / 微小環境
Outline of Final Research Achievements

In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. In this experiment, we found that apelin normalizes tumor vasculature, resulting in improvement of drug delivery and tumor immunity.

Report

(7 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Products Report
  • Research Products

    (93 results)

All 2020 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article (46 results) (of which Peer Reviewed: 46 results,  Acknowledgement Compliant: 3 results,  Open Access: 4 results) Presentation (36 results) (of which Invited: 21 results) Remarks (5 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 3 results)

  • [Journal Article] APJ Regulates Parallel Alignment of Arteries and Veins in the skin2015

    • Author(s)
      Kidoya K, Naito H, Muramatasu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N
    • Journal Title

      Dev Cell

      Volume: inpress

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart.2015

    • Author(s)
      Kainuma S, Miyagawa S, Fukushima S, Pearson J, Chen YC, Saito A, Harada A, Shiozaki M, Iseoka H, Watabe T, Watabe H, Horitsugi G, Ishibashi M, Ikeda H, Tsuchimochi H, Sonobe T, Fujii Y, Naito H, Umetani K, Shimizu T, Okano T, Kobayashi E, Daimon T, Ueno T, Kuratani T, Toda K, Takakura N, Hatazawa J, Shirai M, Sawa Y.
    • Journal Title

      Mol Ther

      Volume: 23 Issue: 2 Pages: 374-386

    • DOI

      10.1038/mt.2014.225

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of PSF1 as a prognostic biomarker for prostate cancer.2015

    • Author(s)
      Tahara H, Naito H, Kise K, Wakabayashi T, Kamoi K, Okihara K, Yanagisawa A, Nakai Y, Nonomura N, Morii E, Miki T, Takakura N
    • Journal Title

      Prostate Cancer Prostatic Dis

      Volume: 18 Issue: 1 Pages: 56-62

    • DOI

      10.1038/pcan.2014.46

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.2015

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Issue: 13 Pages: 4086-4091

    • DOI

      10.1073/pnas.1417273112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells.2014

    • Author(s)
      Gong Z-Y, Kidoya H, Mohri T, Han Y, Takakura N
    • Journal Title

      PLoS One

      Volume: 9 Issue: 10 Pages: e110483-e110483

    • DOI

      10.1371/journal.pone.0110483

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart2014

    • Author(s)
      Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 4452-4452

    • DOI

      10.1038/ncomms5552

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.2014

    • Author(s)
      Yamamoto S, Yamazaki T, Komazaki S, Yamashita T, Osaki M, Matsubayashi M, Kidoya H, Takakura N, Yamazaki D, Kakizawa S
    • Journal Title

      Dev Biol

      Volume: 393 Issue: 1 Pages: 33-43

    • DOI

      10.1016/j.ydbio.2014.06.024

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014

    • Author(s)
      Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
    • Journal Title

      Diabetologia

      Volume: 57 Issue: 9 Pages: 1968-1976

    • DOI

      10.1007/s00125-014-3306-9

    • NAID

      120005463349

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the sternness and drug resistance of malignant cancer cells in the tumor microenvironment.2014

    • Author(s)
      Yumi Kinuoasa, Takahiro Matsui, Nobuyuki Takakura.
    • Journal Title

      Stem Cells

      Volume: 32(1) Issue: 1 Pages: 145-156

    • DOI

      10.1002/stem.1556

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of niche molecules for the maintenance of cardiac stem cells.2013

    • Author(s)
      Takakura N
    • Journal Title

      Circ J.

      Volume: 78 Pages: 69-70

    • NAID

      130003382197

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of novel DNA vaccine for VEGF in murine cancer model.2013

    • Author(s)
      Kyutoku M
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3380-3380

    • DOI

      10.1038/srep03380

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of SLD5 for Early Embryogenesis.2013

    • Author(s)
      Mohri T
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e78961-e78961

    • DOI

      10.1371/journal.pone.0078961

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heregulin Induces Resistance to Lapatinib-mediated Growth Inhibition of HER2-Amplified Cancer Cells.2013

    • Author(s)
      Sato Y
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 12 Pages: 1618-1625

    • DOI

      10.1111/cas.12290

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes.2013

    • Author(s)
      Kawahara H, Naito H, Takara K, Wakabayashi T, Kidoya H, Takakura N.
    • Journal Title

      PLos One

      Volume: 8 Issue: 6 Pages: e65499-e65499

    • DOI

      10.1371/journal.pone.0065499

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-3 accelerates m2 macrophage infiltration and angiogenesis in tumors.2013

    • Author(s)
      Jia W
    • Journal Title

      Am J Pathol.

      Volume: 182 Issue: 5 Pages: 1821-1831

    • DOI

      10.1016/j.ajpath.2013.01.017

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1.2013

    • Author(s)
      Yamakawa D
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 18 Pages: 12469-12477

    • DOI

      10.1074/jbc.m112.433979

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible role of mural cell covered mature blood vessels in inducing drug resistance in cancer-initiating cells.2013

    • Author(s)
      Takahiro Matsui, Yumi Kinugasa, Hidekazu Tahara, Yuzuru Kanakura, Nobuyuki Takakura
    • Journal Title

      The American Journal of Pathology

      Volume: 182 Issue: 5 Pages: 1790-1799

    • DOI

      10.1016/j.ajpath.2013.01.019

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration.2013

    • Author(s)
      Wakabayashi T, Naito H, Takara K, Kidoya H, Sakimoto S, Oshima Y, Nishida K, Takakura N
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 54 Issue: 10 Pages: 6686-6693

    • DOI

      10.1167/iovs.13-12342

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of Trib1 for the differentiation of adipose tissue-resident macrophages maintaining metabolic homeostasis.2013

    • Author(s)
      Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S
    • Journal Title

      Nature

      Volume: 495(7442) Issue: 7442 Pages: 524-528

    • DOI

      10.1038/nature11930

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An angiogenic role for adrenomedullin in choroidal neovascularization.2013

    • Author(s)
      Sakimoto S, Kidoya H, Kamei M, Naito H, Yamakawa D, Sakaguchi H, Wakabayashi T, Nishida K, Takakura N.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e58096-e58096

    • DOI

      10.1371/journal.pone.0058096

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose Angiopoietin-12013

    • Author(s)
      Yamakawa D
    • Journal Title

      J Biol Chem

      Volume: 掲載確定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity2013

    • Author(s)
      Sawane M
    • Journal Title

      Diabetes

      Volume: 掲載確定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moqoclonal antibody selectively recognizing murine but not human CD44.2012

    • Author(s)
      Yumi Kinugasa. Nobuyuki Takakura
    • Journal Title

      Hybridoma (Larchmt)

      Volume: 31(4) Issue: 4 Pages: 262-266

    • DOI

      10.1089/hyb.2012.0021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biology of the apelin-APJ axis in vascular formation.2012

    • Author(s)
      Kidoya H, Takakura N.
    • Journal Title

      J Biochem

      Volume: 152(2) Issue: 2 Pages: 125-131

    • DOI

      10.1093/jb/mvs071

    • NAID

      10031166121

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice2012

    • Author(s)
      Sakimoto S.
    • Journal Title

      Development

      Volume: (In press) Issue: 7 Pages: 1327-1335

    • DOI

      10.1242/dev.072330

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy2012

    • Author(s)
      Kidoya H.
    • Journal Title

      Oncogene

      Volume: (In press) Issue: 27 Pages: 3254-64

    • DOI

      10.1038/onc.2011.489

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of endothelial class II PI3K-C2αin angiogenesis and vascular barrier function2012

    • Author(s)
      Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz JR, Okamoto H, Sasaki T,Matsui O, Asano M, Adams HR, Takakura N, Takuwa Y.
    • Journal Title

      Nature med

      Volume: 18 Issue: 10 Pages: 1560-1569

    • DOI

      10.1038/nm.2928

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origins and properties of dental, thymic, and bone marrow mesenchymal cells and their stem cells2012

    • Author(s)
      Komada Y, Yamane T, Kadota D, Isono K,Takakura N, Hayashi S, Yamazaki H
    • Journal Title

      PLoS One

      Volume: 7(11) Issue: 11 Pages: e46436-e46436

    • DOI

      10.1371/journal.pone.0046436

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation2012

    • Author(s)
      kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, and Shizuo Akira
    • Journal Title

      Immunity

      Volume: 37 Issue: 6 Pages: 1024-1036

    • DOI

      10.1016/j.immuni.2012.08.022

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin2012

    • Author(s)
      Muramatsu F.
    • Journal Title

      Oncogene

      Volume: (In press) Issue: 4 Pages: 414-421

    • DOI

      10.1038/onc.2012.68

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of Lymphatic Integrity by Angiopoietin-1/Tie2 Signaling during Inflammation2012

    • Author(s)
      Kajiya K.
    • Journal Title

      Am J Pathol.

      Volume: 180 Issue: 3 Pages: 1273-1282

    • DOI

      10.1016/j.ajpath.2011.11.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mutual relationship between vascular biology and hematology2012

    • Author(s)
      Takakura N. Guest editorial
    • Journal Title

      Int J Hematol

      Volume: 95 Issue: 2 Pages: 117-118

    • DOI

      10.1007/s12185-012-1014-0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of non-vascular stem cells in blood vessel formation2012

    • Author(s)
      Takakura N.
    • Journal Title

      Int J Hematol.

      Volume: 95 Issue: 2 Pages: 138-142

    • DOI

      10.1007/s12185-012-1011-3

    • NAID

      10030267223

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation and regulation of the cancer stem cell niche2012

    • Author(s)
      Takakura N.
    • Journal Title

      Cancer Sci.

      Volume: (In press) Issue: 7 Pages: 1177-1181

    • DOI

      10.1111/j.1349-7006.2012.02270.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of intimate interactions between endothelial cells and the surrounding accessory cells in the maturation of blood vessels2011

    • Author(s)
      Takakura N.
    • Journal Title

      J Thromb Haemost.

      Volume: 9 Pages: 144-150

    • DOI

      10.1111/j.1538-7836.2011.04275.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apelin attenuates UVB-induced edema and inflammation by promoting vessel function2011

    • Author(s)
      Sawane M.
    • Journal Title

      Am J Pathol.

      Volume: 179 Issue: 6 Pages: 2691-2697

    • DOI

      10.1016/j.ajpath.2011.08.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-Methoxycinnamaldehyde inhibits tumor angiogenesis by suppressing Tie2 activation2011

    • Author(s)
      Yamakawa D.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 415 Issue: 1 Pages: 174-180

    • DOI

      10.1016/j.bbrc.2011.10.053

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in blood vessel maturation in the fibrous cap of the tumor rim2011

    • Author(s)
      Naito H.
    • Journal Title

      Cancer Sci.

      Volume: 103 Issue: 3 Pages: 433-438

    • DOI

      10.1111/j.1349-7006.2011.02157.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a resident vascular stem/ progenitor cell population in preexisting blood vessels2011

    • Author(s)
      Naito H, Kidoya H, Sakimoto S, Wakabayashi T, Takakura N
    • Journal Title

      EMBO J.

      Volume: 31 Issue: 4 Pages: 842-855

    • DOI

      10.1038/emboj.2011.465

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model2011

    • Author(s)
      Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 1451-1455

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling2011

    • Author(s)
      Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I
    • Journal Title

      Circ Res

      Volume: 108 Pages: 664-675

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia2010

    • Author(s)
      Kidoya H, Naito H, Takakura N
    • Journal Title

      Blood

      Volume: 115 Pages: 3166-3174

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor : investigation based on a new S1P3 receptor antagonist2010

    • Author(s)
      Murakami A, Takasugi H, Ohnuma S, Koide Y, Sakurai A, Takeda S, Hasegawa T, Sasamori J, Konno T, Hayashi K, Watanabe Y, Mori K, Sato Y, Takahashi A, Mochizuki N, Takakura N
    • Journal Title

      Mol Pharmacol

      Volume: 77 Pages: 704-713

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of PSF1 promotes the growth of breast cancer cells2010

    • Author(s)
      Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 1015-1024

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010

    • Author(s)
      Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S
    • Journal Title

      Cell Metab

      Volume: 12 Pages: 483-495

    • NAID

      120002661942

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of endothelial tip cell-enriched genes2010

    • Author(s)
      del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A
    • Journal Title

      Blood

      Volume: 116 Pages: 4025-4033

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 既存血管における血管内皮幹細胞システムの解明2015

    • Author(s)
      高倉伸幸
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Maintenance of the stemness in cancer stem cells requires CD44 expressed by tumor stromal cells via tissue hypoxia2015

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      Joint International Symposium on TGF-β and Cancer
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2015-01-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Discovery of endothelial stem like cell for the maintenance of blood vessels2014

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      CREST International Symposium on Homeodynamics during Development and Diseases
    • Place of Presentation
      八芳園(東京)
    • Year and Date
      2014-12-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulation of angiogenesis in the tumor microenvironment2014

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      The 31st Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      ウインク愛知(名古屋)
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Discovery of endothelial stem cells and their application in the tissue regeneration2014

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      2014 Annual Meeting of Vascular Science and Medicine Organization at Busan
    • Place of Presentation
      Haeundae (海雲臺) Grand Hotel(韓国釜山)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] がん幹細胞ニッチの形成と制御2014

    • Author(s)
      高倉 伸幸
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-07-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 血管形成と幹細胞制御2014

    • Author(s)
      高倉 伸幸
    • Organizer
      第38回日本リンパ学会総会
    • Place of Presentation
      北里大学薬学部コンベンションホール(東京)
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cancer stem cells and their vascular niche formation2014

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      2014 Korean Society for Biochemistry and Molecular Biology (KSBMB) Annual Meeting
    • Place of Presentation
      COEX(韓国・ソウル)
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Requirement of endothelial stem cell population for the maintenance and reconstitution of blood vessels2014

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこメッセ(京都)
    • Year and Date
      2014-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] New approach for cancer treatment2014

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      Asia Partnership Conference of Pharmaceutical Associations
    • Place of Presentation
      帝国ホテル(東京)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tumor mature blood vessel specific drug delivery is required for disruption of cancer stem vascular niche2012

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      第20回日本血管生物医学会学術集会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2012-12-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Requirement for perivascular niche for maintenance of cancer stemcells2012

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血管成熟化過程の分子機構2012

    • Author(s)
      高倉 伸幸
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血管成熟化過程におけるアクセサリー細胞の役割2012

    • Author(s)
      高倉 伸幸
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2012-06-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Requirement of endothelial stem-like cells and Tie2-APJ axis for mature blood vessel formation.2012

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      The International Vascular Biology Meeting (IVBM)2012
    • Place of Presentation
      Rhein-Main-Hallen(ドイツ)
    • Year and Date
      2012-06-03
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Identification of endothelial stem like cells in preexisting blood vessels2012

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      2012Suzhou International Symposium on Basic and Translational Vascular Research
    • Place of Presentation
      Soochow University(中国)
    • Year and Date
      2012-05-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血管成熟化による血管病の治療戦略2012

    • Author(s)
      高倉 伸幸
    • Organizer
      第49回日本臨床分子医学会学術総会
    • Place of Presentation
      みやこめっせ(京都)
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cancer stem cells and their vascular niche2011

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)(招待講演)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impact of blood vessel maturation on vascular diseases2011

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      University of Washington-Kobe University Joint Symposium on Integrative Membrane Biology and Signal Transduction Medicine
    • Place of Presentation
      神戸ポートピアホテル(神戸)(invited speaker)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of endothelial stem cell population in the pre-existing blood vessels2011

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      The 1^<st> Asia-Pacific Vascular Biology Meeting
    • Place of Presentation
      東京ステーションコンファレンス(東京)(invited speaker)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cancer stem cells and their vascular niche2011

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      The 2^<nd> Pacific Symposium on Vascular Biology
    • Place of Presentation
      Shilla Hotel(済州島・韓国)(invited speaker)
    • Year and Date
      2011-11-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cancer stem cells and their vascular niche2011

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      日本脳神経外科学会第70回学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)(招待講演)
    • Year and Date
      2011-10-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular Analysis of Blood Vessel Maturation2011

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      XXIII Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      国立京都国際会館(京都)(invited speaker)
    • Year and Date
      2011-07-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管新生における血管成熟化の意義2011

    • Author(s)
      高倉伸幸
    • Organizer
      第63回日本細胞生物学会
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cancer stem cells and their vascular niche2011

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The impact of blood vessel maturation on tumor growth2010

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      第18回日本血管生物医学会学術集会、The 8^<th> Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cancer stem cells and their vascular niche2010

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん幹細胞の生態学的適所である血管ニッチの形成2010

    • Author(s)
      高倉伸幸
    • Organizer
      日本分子生物学会第10回春季シンポジウム
    • Place of Presentation
      宮城県松島(招待講演)
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生過程における血管成熟化の分子機構の解明2010

    • Author(s)
      高倉伸幸
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生における血管内皮幹細胞様システム2010

    • Author(s)
      高倉伸幸
    • Organizer
      第33回日本血栓止血学会学術集会
    • Place of Presentation
      鹿児島県(招待講演)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of endothelial stem like cells in the preexisting blood vessels.

    • Author(s)
      高倉 伸幸
    • Organizer
      第8回研究所ネットワーク国際シンポジウム
    • Place of Presentation
      京都市(京都大学・芝蘭会館)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Growth and maintenance of blood vessels by endothelial stem like cells.

    • Author(s)
      高倉 伸幸
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 血管の幹細胞システム-オーバービュー

    • Author(s)
      高倉 伸幸
    • Organizer
      第21回日本血管生物医学会学術総会
    • Place of Presentation
      大阪府(千里阪急ホテル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 血管ニッチと幹細胞性制御

    • Author(s)
      高倉 伸幸
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Regulation of angiogenesis in vascular diseases.

    • Author(s)
      高倉 伸幸
    • Organizer
      12th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 内皮幹細胞による血管の形成と維持

    • Author(s)
      高倉 伸幸
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都市(国立京都国際会館)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 大阪大学微生物病研究所情報伝達分野

    • URL

      http://st.biken.osaka-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究所ホームページ

    • URL

      http://st.biken.osaka-u.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://st.biken.osaka-u.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://st.biken.osaka-u.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://st.biken.osaka-u.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 白血球浸潤促進剤および腫瘍免疫活性化剤2020

    • Inventor(s)
      高倉伸幸、内藤尚道、高良和弘
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2020
    • Related Report
      Products Report
    • Overseas
  • [Patent(Industrial Property Rights)] 白血球浸潤促進剤および腫瘍免疫活性化剤2020

    • Inventor(s)
      高倉伸幸、内藤尚道、高良和弘
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2020
    • Related Report
      Products Report
    • Overseas
  • [Patent(Industrial Property Rights)] 白血球浸潤促進剤および腫瘍免疫活性化剤2020

    • Inventor(s)
      高倉伸幸、内藤尚道、高良和弘
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2020
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 白血球浸潤促進剤および腫瘍免疫活性化剤2020

    • Inventor(s)
      高倉伸幸、内藤尚道、高良和弘
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2020
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 白血球浸潤促進剤および腫瘍免疫活性化剤2016

    • Inventor(s)
      高倉伸幸、内藤尚道、高良和弘
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 白血球浸潤促進剤および腫瘍免疫活性化剤2016

    • Inventor(s)
      高倉伸幸、内藤尚道、高良和弘
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Related Report
      Products Report
    • Overseas

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Published: 2010-08-23   Modified: 2023-03-30  

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