| Budget Amount *help |
¥82,550,000 (Direct Cost: ¥63,500,000、Indirect Cost: ¥19,050,000)
Fiscal Year 2014: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2012: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2011: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2010: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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| Outline of Final Research Achievements |
We have developed a new biological fluorescence observation system in combination with a fluorescence zoom microscopy and a confocal laser microscopy. Using the mew microscopy system, cancer cells and blood vessels could be visualized in real-time from whole tumor tissues of mouse to single cell levels. I addition, we developed several cell lines that can be visualized cell cycle progression and TGF-beta signaling. Finally, cell cycle and TGF-beta signaling of cancer cells as well as protease activity of tumor microenvironment including Cathepsins and MMPs were visualized and evaluated in vivo.
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