| Budget Amount *help |
¥109,850,000 (Direct Cost: ¥84,500,000、Indirect Cost: ¥25,350,000)
Fiscal Year 2014: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2013: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2010: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
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| Outline of Final Research Achievements |
Germinal centers are the important site for the production of high affinity antibodies against pathogenic microbes. Our study revealed where in the lymphoid tissues B cells become committed to differentiation to germinal center B cells. Real time imaging analyses showed that the transcription factor Bcl6 plays an important role in B cell immigration into germinal centers. Imaging analyses also revealed that S1PR2, a receptor for sphingosine-1-phosophate, expressed by germinal center helper T cells is critical for their retention in germinal centers. In addition, our imaging analyses identified a subset of dendritic cells that is likely to be the most important for cytotoxic T lymphocyte development and differentiation, which are critical for tumor immunity.
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