| Budget Amount *help |
¥129,870,000 (Direct Cost: ¥99,900,000、Indirect Cost: ¥29,970,000)
Fiscal Year 2014: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2013: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2012: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2011: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2010: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
|
|---|
| Outline of Final Research Achievements |
HTLV-1 bZIP factor (HBZ) gene is encoded in the minus strand of HTLV-1 provirus. The HBZ gene is constantly expressed in ATL cells and HTLV-1 infected cells. HBZ enhances transcription of Foxp3 gene through activation of TGF-β pathway. However, since this expression is unstable, Foxp3+ T cells are converted to Foxp3- T cells, which highly produce IFN-γ. Overproduction of IFN-γ is associated with inflammation and lymphomagenesis. Transcription factors, TCF1 and LEF1, inhibit function of Tax. Therefore, HTLV-1 infected cells are rare in thymic T cells that highly express TCF1 and LEF1. This is the mechanism why HTLV-1 favors effector/memory T cells in vivo.
|
