| Budget Amount *help |
¥129,870,000 (Direct Cost: ¥99,900,000、Indirect Cost: ¥29,970,000)
Fiscal Year 2014: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2013: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2012: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2011: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2010: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
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| Outline of Final Research Achievements |
Chronic infection with Helicobacter pylori is associated with gastric cancer development. We have investigated the role of inflammation in gastric tumorigenesis using gastric cancer mouse model. Activation of innate immune responses by bacterial infection induced generation of inflammatory microenvironment in gastric tumor tissues, and macrophages are infiltrated and activated. Moreover, we found that macrophage-expressing TNF-alpha plays a role in tumorigenesis through maintenance of tumor cells in undifferentiated status. These results indicate that targeting inflammatory microenvironment will be a possible preventive or therapeutic strategy against gastric cancer.
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