| Budget Amount *help |
¥125,710,000 (Direct Cost: ¥96,700,000、Indirect Cost: ¥29,010,000)
Fiscal Year 2014: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2013: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2012: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2011: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2010: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
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| Outline of Final Research Achievements |
The aim of the project was to investigate the mechanisms of inflammation and immune responses caused by self-derived molecules in the regulation of carcinogenic spiral. First, we found that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express high-level N-glycan structures. Second, we focused on HMGB1, known to cause inflammatory responses, for its role in inflammation and cancer. For this study, we first generated mice that allow conditional inactivation of the HMGB1 gene in a cell- and tissue-specific manner. We adduced evidence that intracellular HMGB1 contributes to the protection of mice from endotoxemia and bacterial infection. In addition, we also found that the loss of HMGB1 in the liver results in dramatic reduction of liver metastasis of tumor cells. Overall, these results suggest a novel direction in the control of carcinogenic spiral by the immune system.
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