| Budget Amount *help |
¥121,160,000 (Direct Cost: ¥93,200,000、Indirect Cost: ¥27,960,000)
Fiscal Year 2014: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2012: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2011: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2010: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
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| Outline of Final Research Achievements |
Neurons receive sensory or synaptic inputs that strike on their dendritic arbors. We employed Drosophila Class IV dendritic arborization neuron (Class IV neuron) to study from and function of the arbors. Self-avoidance of dendritic branches is one of remarkable morphological features of dendritic arbors, and we showed that this self-avoidance requires a novel complex of the seven-pass transmembrane cadherin Flamingo (Fmi) and a LIM domain protein Espinas (Esn). We also performed genome-wide analyses and unraveled genetic programs that produce neuronal subtype-selective morphological traits, such as directional control of dendritic branch extension and overall arbor size. Furthermore, we examined responses of Class IV neurons to sensory inputs at molecular, cellular, and behavior levels, and proposed underlying mechanisms by which
Class IV neurons function as somatosensory polymodal nociceptors responsible for noxious thermal, mechanical, and light sensation.
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