• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Global survey of the prostaglandin receptor-mediated biological actions

Planned Research

Project AreaMachineries of bioactive lipids in homeostasis and diseases
Project/Area Number 22116003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKumamoto University

Principal Investigator

SUGIMOTO Yukihiko  熊本大学, 生命科学研究部(薬), 教授 (80243038)

Co-Investigator(Kenkyū-buntansha) TSUCHIYA Soken  熊本大学, 大学院生命科学研究部, 講師 (80423002)
Co-Investigator(Renkei-kenkyūsha) SEGI Eri (NISHIDA Eri)  東京理科大学, 基礎工学部, 准教授 (70378628)
Research Collaborator INAZUMI Tomoaki  熊本大学, 生命科学研究部, 助教 (80746503)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥130,000,000 (Direct Cost: ¥100,000,000、Indirect Cost: ¥30,000,000)
Fiscal Year 2014: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2013: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2012: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2011: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2010: ¥32,240,000 (Direct Cost: ¥24,800,000、Indirect Cost: ¥7,440,000)
Keywordsプロスタノイド / エイコサノイド / GPCR / シグナル伝達 / 発生 / 雌性生殖生理 / 発現プロファイル / 脂肪細胞 / GPCR / 生殖生理 / プロスタグランジン / ノックアウトマウス / 生殖腺分化
Outline of Final Research Achievements

We characterized and established molecular nature of 12 types of prostaglandin (PG) receptors in zebrafish. Based on the information, we surveyed possible contribution of PG receptor to developmental processes of zebrafish embryos. We finally found that particular PG receptor signals play essential roles at least in gastrulation, vasculogenesis, and so on. We are now investigating molecular mechanisms underlying PG-induced developmental processes in zebrafish, and involvement of PGs in similar processes in mammals.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (96 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (34 results) (of which Peer Reviewed: 31 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (57 results) (of which Invited: 9 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Roles of prostaglandin receptors in female reproduction.2015

    • Author(s)
      Sugimoto Y, Inazumi T, Tsuchiya S
    • Journal Title

      J Biochem

      Volume: 157 Issue: 2 Pages: 73-80

    • DOI

      10.1093/jb/mvu081

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dermal Vγ4(+) γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8(+) T-Cell Activity through TNF-α Production.2015

    • Author(s)
      Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 135 Issue: 4 Pages: 1007-1015

    • DOI

      10.1038/jid.2014.516

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors.2015

    • Author(s)
      Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
    • Journal Title

      Biochim Biophys Acta

      Volume: 1851 Issue: 4 Pages: 414-421

    • DOI

      10.1016/j.bbalip.2014.07.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロスタグランジンによる皮膚マスト細胞の成熟と活性化2015

    • Author(s)
      杉本幸彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 62-67

    • NAID

      40020330437

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.2014

    • Author(s)
      Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K
    • Journal Title

      Nature Immunology

      Volume: 15 Issue: 11 Pages: 1064-9

    • DOI

      10.1038/ni.2992

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostanoid receptors and acute inflammation in skin.2014

    • Author(s)
      Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
    • Journal Title

      Biochimie

      Volume: 107 Pages: 78-81

    • DOI

      10.1016/j.biochi.2014.08.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice2014

    • Author(s)
      Tani Y, Arita M, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H
    • Journal Title

      FASEB J

      Volume: 28 Issue: 9 Pages: 4036

    • DOI

      10.1096/fj.14-251132

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cooperative therapeutic action of retinoic acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer’s disease.2014

    • Author(s)
      Kawahara K, Suenobu M, Ohtsuka H, Kuniyasu A, Sugimoto Y, Nakagomi M, Fukasawa H, Shudo K, Nakayama H
    • Journal Title

      J Alzheimer’s Dis

      Volume: 42 Issue: 2 Pages: 587-605

    • DOI

      10.3233/jad-132720

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.2014

    • Author(s)
      Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T
    • Journal Title

      J Exp Med

      Volume: 211 Issue: 6 Pages: 1063-1078

    • DOI

      10.1084/jem.20132063

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.2014

    • Author(s)
      Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
    • Journal Title

      J. Immunol.

      Volume: 192 Issue: 3 Pages: 1130-1137

    • DOI

      10.4049/jimmunol.1300290

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling.2014

    • Author(s)
      Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
    • Journal Title

      Circulation.

      Volume: 129 Issue: 4 Pages: 487-496

    • DOI

      10.1161/circulationaha.113.004726

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロスタグランジンE2による炎症惹起の分子機構2014

    • Author(s)
      北條寬典、杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 248 Pages: 977-983

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.2013

    • Author(s)
      Taketomi, Y., Morimoto, K., Murakami, M., et al., 他30名
    • Journal Title

      Nature Immunol.

      Volume: (印刷中) Issue: 6 Pages: 554-63

    • DOI

      10.1038/ni.2586

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and pharmacological characterization of zebrafish ‘relaxant’ prostanoid receptors.2013

    • Author(s)
      Tsuge, K., Iwasaki, R., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., and Sugimoto, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 436 Issue: 4 Pages: 685-690

    • DOI

      10.1016/j.bbrc.2013.06.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors.2013

    • Author(s)
      Iwasaki, R., Tsuge, K., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., Sugimoto, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 438 Issue: 2 Pages: 353-358

    • DOI

      10.1016/j.bbrc.2013.07.075

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Birth regulates the initiation of sensory map formation through serotonin signaling.2013

    • Author(s)
      Toda T., Homma D., Tokuoka H., Hayakawa I., Sugimoto Y., Ichinose H. and Kawasaki H
    • Journal Title

      Developmental Cell

      Volume: 27 Issue: 1 Pages: 32-46

    • DOI

      10.1016/j.devcel.2013.09.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗原非依存性急性炎症におけるプロスタグランジンの役割2013

    • Author(s)
      杉本幸彦、森本和志、土屋創健
    • Journal Title

      血栓と循環

      Volume: 21 Pages: 178-182

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.2013

    • Author(s)
      Taketomi Y et al.
    • Journal Title

      Nature Immunol.

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus.2013

    • Author(s)
      Sakaida M et al.
    • Journal Title

      Neuropharmacol.

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functions of Prostaglandin Receptors in Contact Dermatitis and Application to Drug Discovery2012

    • Author(s)
      Morimoto K., Tsachiya S., Sugimoto Y.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 132 Issue: 11 Pages: 1217-1223

    • DOI

      10.1248/yakushi.12-00232-2

    • NAID

      130001871995

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restriction of Mast Cell Proliferation through Hyaluronan Synthesis by Co-cultured Fibroblasts2012

    • Author(s)
      Takano H, Furuta K, Yamashita K, Sakanaka M, Itano N, Gohda E, Nakayama K, Kimata K, Sugimoto Y, Ichikawa A., Tanaka S.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 3 Pages: 408-412

    • DOI

      10.1248/bpb.35.408

    • NAID

      130001872324

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor2012

    • Author(s)
      Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T
    • Journal Title

      J.Neurochem.

      Volume: 120 Issue: 5 Pages: 795-805

    • DOI

      10.1111/j.1471-4159.2011.07567.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracerebral microinjection of interleukin-4/interleukin-13 reduces beta-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young APP23 mice2012

    • Author(s)
      Kawahara K, Suenobu M, Yoshida A, Koga K, Hyodo A, Ohtsuka H, Kuniyasu A, Tamamaki N, Sugimoto Y, Nakayama H
    • Journal Title

      Neuroscience

      Volume: 207 Pages: 243-260

    • DOI

      10.1016/j.neuroscience.2012.01.049

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The intrinsic prostaglandin E(2)-EP(4) system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice2012

    • Author(s)
      Nakagawa N, Yuhki KI, Kawabe JI, Fujino T, Takahata O, 他9名
    • Journal Title

      Kidney Int

      Volume: (in press) Issue: 2 Pages: 158-171

    • DOI

      10.1038/ki.2012.115

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attelluates aortic aneurysm formation2012

    • Author(s)
      Yokoyama U
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e36724-e36724

    • DOI

      10.1371/journal.pone.0036724

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation2012

    • Author(s)
      Yokoyama, U., Ishiwata, R., Jin, M., Kato, Y., Suzuki, O., Jin, H., Ichikawa, Y., Kumagaya, S., Katayama, Y., Fujita, T., Okumura, S., Sato, M., Sugimoto, Y., Aoki, H., Suzuki, S., Masuda, M., Minamisawa, S., Ishikawa, Y.
    • Journal Title

      PLOS One

      Volume: (印刷中)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E_2-EP4signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism2011

    • Author(s)
      Inazumi, T., Shirata, N., Morimoto, K., Takano, H., Nishida, S.E., Sugimoto, Y.
    • Journal Title

      J Lipid Res

      Volume: 52 Issue: 8 Pages: 1500-1508

    • DOI

      10.1194/jlr.m013615

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling.2010

    • Author(s)
      Tamba, S., Yodoi, R., Morimoto, K., Sugimoto, Y., et al.
    • Journal Title

      Biochimie

      Volume: 92 Pages: 665-675

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads.2010

    • Author(s)
      Kusaka, M., Katoh-Fukui, Y., Ogawa, H., Miyabayashi, K., Baba, T., Shima, Y., Sugimoto, Y., Morohashi, K, et al.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5893-5904

    • NAID

      120005227384

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.2010

    • Author(s)
      Katoh, H., Hosono, K., Ito, Y., Suzuki, T., Ogawa, Y., Kubo, H., Sugimoto, Y., Narumiya, S., Majima, M., et al.
    • Journal Title

      Am.J.Pathol.

      Volume: 176 Pages: 1469-1483

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Prostaglandin E2-EP1 Receptor Signaling in Regulation of Gastric Motor Activity and Emptying.2010

    • Author(s)
      Mizuguchi, S., Ohno, T., Hattori, Y., Ae, T., Minamino, T., Satoh, T., Arai, K., Saeki, T., Hayashi, I., Sugimoto, Y., et al.
    • Journal Title

      Am.J.Physiol.Gastrointest.Liver Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation.2010

    • Author(s)
      Ueno, T., Suzuki, T., Oikawa, A., Hosono, K., Kosaka, Y., Amano, H., Kitasato, H., Ito, Y., Sugimoto, Y., Narumiya, S., et al.
    • Journal Title

      Biomed.Pharmacother.

      Volume: 64 Pages: 93-100

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangi ogenesis.2010

    • Author(s)
      Kubo, H., Hosono, K., Suzuki, T., Ogawa, Y., Kato, H., Kamata, H., Ito, Y., Amano, H., Sugimoto, Y., Narumiya, S., et al.
    • Journal Title

      Biomed.Pharmacother.

      Volume: 64 Pages: 101-106

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular biology of histidine decarboxylase and prostaglandin receptors.2010

    • Author(s)
      Ichikawa, A., Sugimoto, Y., Tanaka, S.
    • Journal Title

      Proc.Jpn.Acad.

      Volume: 86 Pages: 848-866

    • NAID

      130000442356

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ゼブラフィッシュ発生過程におけるプロスタグランジン受容体の役割-NSAIDsによる胎児毒性の解明に向けて2015

    • Author(s)
      土屋創健, 杉本幸彦
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Prostaglandin E2-EP3 signaling triggers mast cell activation and acute inflammation.2015

    • Author(s)
      Sugimoto Y
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Physiological regulation of adipocyte function by prostaglandin E2.2015

    • Author(s)
      Inazumi T, Tsuchiya S, Narumiya S, Sugimoto Y
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of multiple prostanoid receptors in embryo implantation and spacing.2015

    • Author(s)
      Tsuchiya S, Ma X, Okubo K, Inazumi T, Sugimoto T, Horikoshi Y, Takeo T, Nakagata N, Narumiya S, Sugimoto Y
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prostaglandin E2 facilitates neurite outgrowth in preoptic neurons.2015

    • Author(s)
      Hohjoh H, Yoshioka M, Tsuchiya H, Tsuchiya S, Misumi S, Segi-Nishida E, Sugimoto Y
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The roles of prostanoid receptors during somite stages of zebrafish development.2015

    • Author(s)
      Tsuge K, Iwasaki R, Kishimoto K, Inazumi T, Kawahara A, Tsuchiya S, Sugimoto Y
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of prostanoid receptors in vasculogenesis of zebrafish.2015

    • Author(s)
      Iwasaki R, Tsuge K, Inazumi T, Kawahara A, Tsuchiya S, Sugimoto Y
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゼブラフィッシュ初期発生におけるプロスタグランジンI2-IP受容体シグナルの役割解析2014

    • Author(s)
      岸本幸一朗, 告恭史郎, 岩﨑亮, 川原敦雄, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第30回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタグランジンEP4受容体を介した脂質代謝調節機構2014

    • Author(s)
      山田清隆, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第30回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタグランジンE2-EP4による視索前野ニューロンの神経突起伸長制御2014

    • Author(s)
      北條寛典, 吉岡美樹, 土屋裕義, 土屋創健, 三隅将吾, 瀬木-西田恵里, 杉本幸彦
    • Organizer
      第8回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタグランジン受容体EP2 におけるGs/β -arrestin シグナル活性化の相関2014

    • Author(s)
      江口幸臣, 松永拓子, 告恭史郎, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第8回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prostaglandin E2 - EP3 signaling triggers acute inflammation by mast cell activation2014

    • Author(s)
      Sugimoto Y
    • Organizer
      5th European Workshop on Lipid Mediators
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of prostaglandin EP4 receptor in adipose tissue2014

    • Author(s)
      Inazumi T, Tsuchiya S, Narumiya S, Sugimoto Y
    • Organizer
      5th European Workshop on Lipid Mediators
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 初期発生におけるゼブラフィッシュ・プロスタノイド受容体の役割2014

    • Author(s)
      岩崎亮, 告恭史郎, 川原敦雄, 土屋創健, 杉本幸彦
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 着床時子宮における Ca2+動員型プロスタグランジン受容体の機能2014

    • Author(s)
      馬驍彦, 稲住知明, 杉本聡子, 土屋創健, 堀越裕佳, 竹尾透, 中潟直己, 成宮周, 杉本幸彦
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタサイクリン受容体IPによるIL-33誘導性サイトカイン産生の抑制メカニズム2014

    • Author(s)
      鈴木 佑治, 渡辺 真由帆, 森本 和志, 土屋 創健, 杉本 幸彦
    • Organizer
      第13回次世代を担う若手ファーマ・バイオフォーラム2014
    • Place of Presentation
      富山
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタグランジンEP4受容体による視索前野ニューロンの細胞骨格制御2014

    • Author(s)
      北條寛典, 吉岡美樹, 土屋裕義, 土屋創健, 川原浩一, 三隅将吾, 瀬木-西田恵里, 杉本幸彦
    • Organizer
      第56回 日本脂質生化学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタグランジン受容体と雌性生殖生理2014

    • Author(s)
      杉本幸彦
    • Organizer
      第11回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-09 – 2014-05-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] プロスタノイド受容体の構造解析へのアプローチ2014

    • Author(s)
      豊田洋輔, 関口雄介, 浅田秀基, 寿野良二, 中根崇根, 椎村裕樹, 中北智哉, 森本和志, 稲住知明, 告恭史郎, 杉本幸彦, 岩田想, 成宮周, 小林拓也
    • Organizer
      第11回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-09 – 2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪組織におけるプロスタグランジンの生理機能2014

    • Author(s)
      杉本幸彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュGs共役型プロスタグランジン受容体の基盤解析2013

    • Author(s)
      告恭史郎、岩崎亮、川原敦雄、土屋創健、杉本幸彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロスタグランジンの新たな生理機能2013

    • Author(s)
      杉本幸彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュCa2+動員型プロスタノイド受容体の薬理学的解析2013

    • Author(s)
      岩崎亮、川原敦雄、井上飛鳥、青木淳賢、土屋創健、杉本幸彦
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂肪細胞におけるプロスタグランジンEP4受容体の機能解析2013

    • Author(s)
      稲住知明、土屋創健、成宮 周、杉本幸彦
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      松島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 魚類における性行動発現の嗅覚メカニズム:性フェロモン・プロスタグランジンF2aが活性化するゼブラフィッシュ嗅覚受容体および神経回路素子の同定2013

    • Author(s)
      矢吹陽一、小出哲也、宮坂信彦、脇阪紀子、増田美和、告恭史郎、杉本幸彦、渡邉和忠、吉原良浩
    • Organizer
      Neuro2013 第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandins, mast cells and acute inflammation.2013

    • Author(s)
      Yukihiko Sugimoto.
    • Organizer
      FASEB Science Research Conferences, Lysophospholipid and other Related Mediators - From Bench to Clinic
    • Place of Presentation
      Niseko, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of embryo implantation and spacing by multiple prostanoid receptors.2013

    • Author(s)
      Tsuchiya, S., Ma, X.-Y., Inazumi, T., Sugimoto, T., Takeo, T., Nakagata, N., Narumiya, S., and Sugimoto, Y.
    • Organizer
      FASEB Science Research Conferences, Lysophospholipid and other Related Mediators - From Bench to Clinic
    • Place of Presentation
      Niseko, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] プロスタグランジンによる炎症惹起の分子機構2013

    • Author(s)
      杉本幸彦
    • Organizer
      生体機能と創薬シンポジウム2013
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IL-33誘導性マスト細胞応答におけるプロスタサイクリン受容体IPの役割2013

    • Author(s)
      鈴木佑治, 渡辺真由帆, 森本和志, 土屋創健, 成宮 周, 杉本幸彦
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] プロスタグランディンと雌性生殖生理2013

    • Author(s)
      杉本幸彦
    • Organizer
      フォーラム2013:衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンEP4受容体による視索前野ニューロンの細胞骨格制御2013

    • Author(s)
      北條寛典、吉岡美樹、土屋裕義、土屋創健、川原浩一、三隅将吾、瀬木-西田恵里、杉本幸彦
    • Organizer
      第12回次世代を担う若手ファーマ・バイオフォーラム2013
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandins, Masct Cells, and Acute Inflammation.2013

    • Author(s)
      Sugimoto, Y., Morimoto, K., Tsuchiya, S., Taketomi, Y., Murakami, M., and Shuh Narumiya.
    • Organizer
      16th GEM-10th GERLI lipidomics meeting
    • Place of Presentation
      Saint-Jean-Cap-Ferrat, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] プロスタグランジンF受容体FPの可視化系の構築2013

    • Author(s)
      平井友貴、北條寛典、杉本聡子、野中夏姫、高宗暢暁、三隅将吾、土屋創健、杉本幸彦
    • Organizer
      第29回日本薬学会九州支部大会
    • Place of Presentation
      佐世保
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗原非依存性炎症におけるプロスタグランジンの役割2012

    • Author(s)
      森本和志、白田成俊、武富芳隆、土屋創健、瀬木-西田恵里、田中智之、椛島健治、村上誠、成宮周、杉本幸彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンEP4受容体は脂肪細胞のインスリン応答を抑制する2012

    • Author(s)
      稲住知明、白田成俊、瀬木-西田恵里、土屋創健、杉本幸彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-33誘導性マスト細胞応答におけるプロスタグランジンI2受容体IPの役割2012

    • Author(s)
      渡辺真由帆、森本和志、土屋創健、成宮周、杉本幸彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゼブラフィッシュGs共役型プロスタグランジン受容体の性状解析2012

    • Author(s)
      告恭史郎、岩崎亮、川原敦雄、土屋創健、杉本幸彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゼブラフィッシュカルシウム動員系プロスタノイド受容体の性状解析2012

    • Author(s)
      岩崎亮、川原敦雄、井上飛鳥、青木淳賢、土屋創健、杉本幸彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ca2+動員型プロスタグランジン受容体は着床時のEmbryo-spacingに必須の役割を果たす2012

    • Author(s)
      馬 驍彦、稲住知明、杉本聡子、土屋創健、川原浩一、竹尾透、中潟直己、成宮周、杉本幸彦
    • Organizer
      第28回日本薬学会九州支部大会
    • Place of Presentation
      熊本大学薬学部(熊本)
    • Year and Date
      2012-12-08
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロスタグランジンEP4受容体は脂肪細胞のインスリン応答を抑制する2012

    • Author(s)
      稲住知明、白田成俊、土屋創健、瀬木-西田恵里、成宮周、杉本幸彦
    • Organizer
      第11回次世代を担う若手ファーマ・バイオフォーラム2012
    • Place of Presentation
      九州大学馬出キャンパス(福岡)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロスタグランジンE2はマスト細胞のEP3受容体に作用して脱顆粒を引き起こし皮膚炎症を惹起する2012

    • Author(s)
      森本和志、白田成俊、武富芳隆、瀬木-西田恵里、田中智之、村上誠、成宮周、杉本幸彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロスタグランジンEP2受容体によるGs/β-arrestin活性化の相関2012

    • Author(s)
      松永拓子、岩崎亮、告恭史郎、稲住知明、森本和志、成宮周、杉本幸彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるmicroRNA-210の癌細胞増殖抑制効果2012

    • Author(s)
      土屋創建、嶋田裕、杉本幸彦、辻本豪三、清水一治
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪細胞の分化・成熟における内因性プロスタグランジンの役割2011

    • Author(s)
      稲住知明、白田成俊、瀬木-西田恵里, 成宮周、杉本幸彦
    • Organizer
      第10回次世代を担う若手ファーマ・バイオフォーラム2011
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2011-10-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロスタグランジンE2はEP4受容体を介してマウス視床下部神経細胞の突起伸長を促進する2011

    • Author(s)
      土屋裕義, 杉本幸彦, 藤原葉子, 藤村昭夫, 輿水崇鏡
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロスタグランジンEP4受容体による視索前野ニューロンの細胞骨格制御の分子機構2011

    • Author(s)
      北條寛典、吉岡美樹、川原浩一、三隅将吾、瀬木-西田恵里、成宮周、杉本幸彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゼブラフィッシュ プロスタノイド受容体のクローニングと性状解析2011

    • Author(s)
      告恭史郎, 岩崎亮, 川原敦雄, 井上飛鳥, 青木淳賢, 杉本幸彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪細胞への分化における内因性プロスタグランジンの役割2011

    • Author(s)
      稲住知明、白田成俊、瀬木-西田恵里杉本幸彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロスタグランジンE2-EP3受容体シグナルはマスト細胞の活性化を介して炎症を惹起する2011

    • Author(s)
      森本和志、白田成俊、武富芳隆、瀬木-西田恵里、田中智之、村上誠、成宮周、杉本幸彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful mammalian fertilization2011

    • Author(s)
      Yukihiko Sugimoto
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Holderness school (Holderness, NH, USA)(招待講演)
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロスタグランジン-ケモカイン相互作用の受精における役割2011

    • Author(s)
      杉本幸彦
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸国際会議場(神戸)(招待講演)
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロスタグランジンE2による視索前野ニューロン突起伸長の促進機構2010

    • Author(s)
      杉本幸彦、吉岡美樹、北條寛典、川原浩一、瀬木-西田恵里、成宮周
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(神戸)(招待講演)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] sPLA2-III, a mast cell-derived anaphylactic sPLA2, regulates mast cell-dependentanaphylactic response.2010

    • Author(s)
      Yoshitaka Taketomi、Hiroyasu Sato、Satoshi Tanaka、Masanori Nakamura、Noriko Ueno、Yasumasa Nishito、Kei Yamamoto、Yukihiko Sugimoto、Shuntaro Hara、Makoto Murakami
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロスタグランジンE2はマスト細胞のEP3受容体を活性化することで炎症を惹起する2010

    • Author(s)
      森本和志、白田成俊、森大介、高野裕嗣、田中智之、瀬木-西田恵里、杉本幸彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] PGE2 stimulation accelerated the neurite growth in mouse hypothalamic cell line.2010

    • Author(s)
      Hiroyasu Tsuchiya、Yukihiko Sugimoto、Yoko Hujiwara、Akio Fujimura、Taka-aki Koshimizu
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪細胞の分化・成熟における内因性プロスタグランジンの役割2010

    • Author(s)
      稲住知明、白田成俊、瀬木-西田恵里、成宮周、杉本幸彦
    • Organizer
      第9回次世代を担う若手ファーマ・バイオフォーラム2010
    • Place of Presentation
      京都大学薬学研究科(京都)
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cumulus Matrix Capacitation for Successful Sperm Penetration : Roles of Prostaglandin and Chemokine2010

    • Author(s)
      Sugimoto, Y.
    • Organizer
      11^<th> International Symposium on Spermatology
    • Place of Presentation
      Okinawa Convention Center (Okinawa)(invited)
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/yseika/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/yseika/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒトプロスタグランジンE2受容体EP4に対する抗体2011

    • Inventor(s)
      高山喜好、清水朋子、漆畑祐司、杉本幸彦
    • Industrial Property Rights Holder
      エヌビィー健康研究所・熊本大学
    • Filing Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ヒトプロスタグランジンE_2受容体EP4に対する抗体2010

    • Inventor(s)
      高山喜好、清水朋子、漆畑祐司、杉本幸彦
    • Industrial Property Rights Holder
      エヌビィー健康研究所・熊本大学
    • Industrial Property Number
      2010-218158
    • Filing Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 不妊治療剤、体外受精促進剤及び不妊治療剤のスクリーニング方法2010

    • Inventor(s)
      杉本幸彦、丹波茂郎、市川厚
    • Industrial Property Rights Holder
      杉本幸彦
    • Acquisition Date
      2010-07-23
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi