| Budget Amount *help |
¥127,790,000 (Direct Cost: ¥98,300,000、Indirect Cost: ¥29,490,000)
Fiscal Year 2014: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2013: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2012: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2011: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2010: ¥32,630,000 (Direct Cost: ¥25,100,000、Indirect Cost: ¥7,530,000)
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| Outline of Final Research Achievements |
Lysophospholipids are phospholipids that have only one acy chains. In the past two decades many GPCRs have been shown to react specifically with some of lysophospholipids. These include receptor for lysophosphatidic acid (LPA) and sphingosine 1 phosphate (S1P). In addition, specific enzymes that produce these lysophosphspholipids have been identified. Interestingly, these receptors and synthetic enzymes for lysophospholipids are highly conserved in vertebrates. Thus, in this study, to identify the patho-physiological roles of lysophospholipids, which is conserved among the wide range of vertebrates, we performed functional analyses of lysophospholipid receptors and synthetic enzymes using zebrafishes and mice as animal models. As one of the results in this study, we found new molecular mechanism underlining the embryonic blood formation mediated by LPA-degrading enzyme.
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