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Novel lipid networks regulated by the phospholipase A2 family

Planned Research

Project AreaMachineries of bioactive lipids in homeostasis and diseases
Project/Area Number 22116005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

MURAKAMI Makoto  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 参事研究員 (60276607)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥137,540,000 (Direct Cost: ¥105,800,000、Indirect Cost: ¥31,740,000)
Fiscal Year 2014: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2013: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2012: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2011: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2010: ¥30,290,000 (Direct Cost: ¥23,300,000、Indirect Cost: ¥6,990,000)
Keywords酵素 / 脂質 / 生体分子 / 遺伝子 / 細胞・組織 / 遺伝子改変マウス / リピドミクス / 病態 / リピドミクスピドミクス / 組織・細胞 / ホスホリパーゼA_2 / トランスジェニックマウス / ノックアウトマウス / 生体膜 / 脂質メタボロミクス / リン脂質 / 脂質メディエーター / 不飽和脂肪酸
Outline of Final Research Achievements

Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze the sn-2 position of phospholipids to generate fatty acids and lysophospholipids. Mammalian genomes encode genes for more than 30 PLA2s or related enzymes, which are subdivided into several groups on the basis of their structures and enzymatic properties. In this study, we used transgenic and knockout mice for various PLA2s in combination with lipidomic analyses to decipher their pathophysiological roles and underlying lipid pathways in various pathophysiological events. From this approach, we successfully identified the novel roles of secreted PLA2s in mast cell maturation and allergy (PLA2G3), resolution of contact hypersensitivity (PLA2G2D), metabolic syndrome (PLA2G5 and PLA2G2E), sperm maturation and fertility (PLA2G3 and PLA2G10), and so on. Overall, this study reveal that the sPLA2 family affects various biological events by modulating extracellular phospholipid milieus in response to given microenvironmental cues.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (145 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (52 results) (of which Peer Reviewed: 34 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (79 results) (of which Invited: 36 results) Book (4 results) Remarks (7 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Secreted phospholipase A2s and mast cells.2015

    • Author(s)
      Murakami, M., and Taketomi, Y.
    • Journal Title

      Allergology Int.

      Volume: 64 Issue: 10 Pages: 4-10

    • DOI

      10.1371/journal.pone.0109409

    • NAID

      130004873126

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A new era of secreted phospholipase A2.2015

    • Author(s)
      Murakami, M., Sato, H., Miki, Y., Yamamoto, K., and Taketomi, Y.
    • Journal Title

      J. Lipid Res.

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] sPLA2と炎症・免疫2015

    • Author(s)
      村上誠
    • Journal Title

      炎症と免疫

      Volume: 23 Pages: 78-86

    • Related Report
      2014 Annual Research Report
  • [Journal Article] リン脂質からオメガ3脂肪酸を動員するホスホリパーゼA22015

    • Author(s)
      村上誠
    • Journal Title

      食品と開発

      Volume: 50 Pages: 9-11

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 接触皮膚炎と抗炎症脂質メディエーター2015

    • Author(s)
      三木寿美、山本圭、村上誠
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 156-163

    • Related Report
      2014 Annual Research Report
  • [Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.2014

    • Author(s)
      Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
    • Journal Title

      Cell Metab.

      Volume: 20 Issue: 1 Pages: 119-132

    • DOI

      10.1016/j.cmet.2014.05.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.2014

    • Author(s)
      Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K, Lambeau G.
    • Journal Title

      Biochimie

      Volume: 107Pt A Pages: 105-113

    • DOI

      10.1016/j.biochi.2014.09.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.2014

    • Author(s)
      Hwang, S.K., Lu, Y., Li, X., Kim, Y.D., Cho, Y.S., Jahng, Y., Son, J.K., Lee, Y.J., Kang, W., Taketomi, Y., Murakami, M., Moon, T.C., and Chang, H.W.
    • Journal Title

      J. Allergy Clin. Immunol.

      Volume: 134 Issue: 3 Pages: 714-721

    • DOI

      10.1016/j.jaci.2014.05.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ホスホリパーゼA2によるマスト細胞の制御2014

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 62 Pages: 659-667

    • Related Report
      2014 Annual Research Report
  • [Journal Article] リン脂質シグナル、PLA2と発がん2014

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      The Lipids.

      Volume: 25 Pages: 70-78

    • Related Report
      2014 Annual Research Report
  • [Journal Article] リン脂質の質と量の変動が全身の代謝を決める:ホスホリパーゼA2による代謝シグナル2014

    • Author(s)
      佐藤弘泰、村上誠
    • Journal Title

      実験医学増刊―驚愕の代謝システム

      Volume: 32 Pages: 27-33

    • Related Report
      2014 Annual Research Report
  • [Journal Article] sPLA2を起点とした脂質ネットワークによる免疫制御の新機軸2014

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      生化学

      Volume: 86 Pages: 286-291

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 分泌性ホスホリパーゼA2による免疫制御2014

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      医学のあゆみ

      Volume: 248 Pages: 949-955

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction.2014

    • Author(s)
      Mishina H, Watanabe K, Tamaru S, Watanabe Y, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Inoue O, Murakami M, Hanasaki K, Kugiyama K.
    • Journal Title

      Circ Res.

      Volume: 114 Issue: 3 Pages: 493-504

    • DOI

      10.1161/circresaha.114.302319

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family2014

    • Author(s)
      Udagawa O, Ito C, Ogonuki N, Sato H, Lee S, Tripvanuntakul P, Ichi I, Uchida Y, Nishimura T, Murakami M, Ogura A, Inoue T, Toshimori K, Arai H.
    • Journal Title

      Genes Cells.

      Volume: 19 Issue: 1 Pages: 13

    • DOI

      10.1111/gtc.12105

    • URL

      https://pure.teikyo.jp/en/publications/a214ef61-5779-4ba6-8fc8-7e46597ecbef

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.2014

    • Author(s)
      Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
    • Journal Title

      J. Immunol.

      Volume: 192 Issue: 3 Pages: 1130-1137

    • DOI

      10.4049/jimmunol.1300290

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators2013

    • Author(s)
      Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
    • Journal Title

      J Exp Med.

      Volume: 210 Issue: 6 Pages: 1217

    • DOI

      10.1084/jem.20121887

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.2013

    • Author(s)
      Taketomi, Y., Morimoto, K., Murakami, M., et al., 他30名
    • Journal Title

      Nature Immunol.

      Volume: (印刷中) Issue: 6 Pages: 554-63

    • DOI

      10.1038/ni.2586

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2-dependent prostaglandin D₂ generation in mast cells and anaphylaxis in mice.2013

    • Author(s)
      Lu Y, Na MK, Suh SJ, Li X, Kim GJ, Chao GH, Jeong YT, Kim DS, Chang YC, Murakami M, Kang W, Kim CH, Chang HW.
    • Journal Title

      Food Chem Toxicol

      Volume: 57 Pages: 307-313

    • DOI

      10.1016/j.fct.2013.03.029

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation.2013

    • Author(s)
      Tamaru S, Mishina H, Watanabe Y, Watanabe K, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Murakami M, Hanasaki K, Kugiyama K.
    • Journal Title

      J Immunol.

      Volume: 191 Issue: 3 Pages: 1021-1028

    • DOI

      10.4049/jimmunol.1300738

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice.2013

    • Author(s)
      Hwang SL, Li X, Lu Y, Jin Y, Jeong YT, Kim YD, Lee IK, Taketomi Y, Sato H, Cho YS, Murakami M, Chang HW.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 132 Issue: 3 Pages: 729-736

    • DOI

      10.1016/j.jaci.2013.02.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 疾病における脂質代謝ネットワークの機能.2013

    • Author(s)
      三木寿美、山本圭、村上誠.
    • Journal Title

      オレオサイエンス.

      Volume: 13 Pages: 23-29

    • NAID

      130005122088

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 脂質メディエーターによるアレルギー制御.2013

    • Author(s)
      武富芳隆、村上誠.
    • Journal Title

      実験医学増刊―病態の理解に向かうアレルギー疾患研究.

      Volume: 31 Pages: 118-127

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 分泌性ホスホリパーゼA2.2013

    • Author(s)
      武富芳隆、村上誠.
    • Journal Title

      The Lipids.

      Volume: 24 Pages: 70-78

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 脂質ネットワークとアナフィラキシー.2013

    • Author(s)
      武富芳隆、村上誠.
    • Journal Title

      アレルギー・免疫.

      Volume: 20 Pages: 38-48

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 分泌性ホスホリパーゼA2による免疫制御.2013

    • Author(s)
      村上誠.
    • Journal Title

      細胞工学.

      Volume: 32 Pages: 1265-1271

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer.2013

    • Author(s)
      Hiyoshi M, Kitayama J, Kazama S, Taketomi Y, Murakami M, Tsuno NH, Hongo K, Kaneko M, Sunami E, Watanabe T.
    • Journal Title

      Oncol Lett.

      Volume: 5 Pages: 533-538

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.2013

    • Author(s)
      Ait-Oufella H, Herbin O, Lahoute C, Coatrieux C, Loyer X, Joffre J, Laurans L, Ramkhelawon B, Blanc-Brude O, Karabina S, Girard CA, Payré C, Yamamoto K, Binder CJ, Murakami M, Tedgui A, Lambeau G, Mallat Z.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Issue: 3 Pages: 466-473

    • DOI

      10.1161/atvbaha.112.300309

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging roles of secreted phospholipase A2 enzymes: an update.2013

    • Author(s)
      Murakami M, Lambeau G.
    • Journal Title

      Biochimie

      Volume: 95 Issue: 1 Pages: 43-50

    • DOI

      10.1016/j.biochi.2012.09.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PGD_2 induces eotaxin-3 via PPARγ from sebocytes : a possible pathogenesis of eosinophilic pustular folliculitis2012

    • Author(s)
      Nakahigashi, K., et al
    • Journal Title

      J.Allergy Clin.Immunol.

      Volume: 129 Issue: 2 Pages: 536-543

    • DOI

      10.1016/j.jaci.2011.11.034

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis2012

    • Author(s)
      Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S
    • Journal Title

      Oncogene

      Volume: 31(24) Issue: 24 Pages: 2943-2952

    • DOI

      10.1038/onc.2011.472

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unraveling the secrets of secreted phospholipase A2.2012

    • Author(s)
      Murakami M, Taketomi Y.
    • Journal Title

      Trends Cell. Mol. Biol.

      Volume: 7 Pages: 57-71

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アナフィラキシーを制御する脂質ネットワーク2012

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 550-559

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans2011

    • Author(s)
      Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., and Yamamoto, K.
    • Journal Title

      Prog. Lipid Res

      Volume: 50 Issue: 2 Pages: 152-192

    • DOI

      10.1016/j.plipres.2010.12.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology2011

    • Author(s)
      Murakami, M., et al
    • Journal Title

      Int.J.Mol.Sci.

      Volume: 12 Issue: 3 Pages: 1474-1495

    • DOI

      10.3390/ijms12031474

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis : integration with lipidomics2011

    • Author(s)
      Yamamoto, K., et al
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400 Issue: 7 Pages: 1829-1842

    • DOI

      10.1007/s00216-011-4864-z

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2 revisited2011

    • Author(s)
      Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
    • Journal Title

      J. Biochem.

      Volume: 150 Issue: 3 Pages: 233-255

    • DOI

      10.1093/jb/mvr088

    • NAID

      10030587186

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin2011

    • Author(s)
      Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 13 Pages: 11616-11631

    • DOI

      10.1074/jbc.m110.206714

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function2011

    • Author(s)
      Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 13 Pages: 11632-11648

    • DOI

      10.1074/jbc.m110.206755

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2alpha, not iPLA2beta, to lipid mobilization in proximal mast cells and distal fibroblasts.2011

    • Author(s)
      Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 186 Issue: 43 Pages: 37249-37263

    • DOI

      10.1074/jbc.m111.290312

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice2011

    • Author(s)
      Miyazaki, T., Taketomi, Y., Takimoto, M., Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
    • Journal Title

      Circulation

      Volume: 124 Issue: 23 Pages: 2522-2532

    • DOI

      10.1161/circulationaha.111.021675

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation2011

    • Author(s)
      Lu, Y., et al
    • Journal Title

      Biochem.Pharmacol.

      Volume: 82 Pages: 1700-1708

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipid mediators in life science2011

    • Author(s)
      Murakami, M.
    • Journal Title

      Exp.Anim

      Volume: 60 Pages: 7-20

    • NAID

      10029549738

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マスト細胞生物学における脂質代謝ネットワーク2011

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 131 Pages: 73-84

    • NAID

      130000451529

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Group III secreted phospholipase A_2 regulates epididymal sperm maturation and fertility in mice2010

    • Author(s)
      Sato, H., Taketomi, T., 他14名, Murakami, M.
    • Journal Title

      J.Clin.Invest.

      Volume: 120 Pages: 1400-1414

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Group X phospholipase A_2 is released during sperm acrosome reaction and controls fertility outcome in mice2010

    • Author(s)
      Escoffier, J., 他12名, Murakami, M., Lambeau, G, Amoult, C.
    • Journal Title

      J.Clin.Invest.

      Volume: 120 Pages: 1415-1428

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca^<2+>-indpendent phospholipase A_2 (iPLA_<2γ>) deficient mice2010

    • Author(s)
      Yoda, E., 他8 名, Murakami, M, Kudo, I., Hara, S.
    • Journal Title

      J.Lipid Res.

      Volume: 51 Pages: 3003-3015

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging roles of secreted phospholipase A_2 enzymes : lessons from transgenic and knockout mice2010

    • Author(s)
      Murakami, M., 他3名, Lambeau, G.
    • Journal Title

      Biochimie

      Volume: 92 Pages: 561-582

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E synthases : understanding their pathophysiological roles through mouse genetic models2010

    • Author(s)
      Hara, S., 他4名, Murakami, M.
    • Journal Title

      Biochimie

      Volume: 92 Pages: 651-659

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分泌性ホスホリパーゼA_22010

    • Author(s)
      村上誠
    • Journal Title

      日薬理誌

      Volume: 135 Pages: 217-218

    • NAID

      10026439447

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 分泌性ホスホリパーゼA_2遺伝子改変マウス2010

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      The Lipid

      Volume: 121 Pages: 4-12

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ホスホリパーゼA_2の生理的・病理的役割2010

    • Author(s)
      村上誠、佐藤弘泰, 平林哲也, 山本圭, 武富芳隆
    • Journal Title

      実験医学

      Volume: 28 Pages: 114-125

    • Related Report
      2010 Annual Research Report
  • [Presentation] New insights into PLA2s from outside and inside.2015

    • Author(s)
      Murakami, M.
    • Organizer
      The 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2分子ファミリーの新しいパラダイム2015

    • Author(s)
      村上誠
    • Organizer
      第161回脂質談話会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2015-01-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 皮膚脂質代謝の新機軸2014

    • Author(s)
      村上誠、平林哲也、山本圭
    • Organizer
      第7回セラミド研究会
    • Place of Presentation
      東京ユビキタス協創広場CANVAS(東京都中央区)
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] リン脂質からオメガ3脂肪酸を動員するホスホリパーゼA22014

    • Author(s)
      村上誠
    • Organizer
      第16回DHA・EPA協議会
    • Place of Presentation
      アイビーホール青学会館(東京都渋谷区)
    • Year and Date
      2014-10-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新規PNPLA/iPLA2の新しい機能2014

    • Author(s)
      平林哲也、村上誠
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 酸化リン脂質選択的ホスホリパーゼA2のマスト細胞脱顆粒シグナルにおける機能2014

    • Author(s)
      河野望、嶋中雄太、武富芳隆、村上誠、新井洋由
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2を起点とした脂質免疫制御と疾患2014

    • Author(s)
      武富芳隆、村上誠
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Novel biological functions of PLA22014

    • Author(s)
      Murakami, M.
    • Organizer
      Nobel Forum: Lipid Mediators in Health and Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2を基軸とした脂質免疫制御2014

    • Author(s)
      武富芳隆、宮崎拓郎、佐藤弘泰、村上誠
    • Organizer
      第35回日本炎症再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 代謝性慢性炎症を制御するメタボリックsPLA22014

    • Author(s)
      村上誠、佐藤弘泰、武富芳隆
    • Organizer
      第35回日本炎症再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Phospholipase A2 and lipid mediators in health and disease2014

    • Author(s)
      Murakami, M.
    • Organizer
      2014 Yonsei-Igakuken Joint Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脂質分解酵素と生活習慣病との関連2014

    • Author(s)
      村上誠
    • Organizer
      第14回日本抗加齢学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-06-07 – 2014-06-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A new era of secreted phospholipase A2 (sPLA2).2014

    • Author(s)
      Murakami M.
    • Organizer
      The 15th International Winter Eicosanoid Conference.
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] sPLA2と免疫抑制.2014

    • Author(s)
      村上誠.
    • Organizer
      第134会日本薬学会.
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Deciphering the physiological functions of sPLA2s.2013

    • Author(s)
      Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K.
    • Organizer
      The 5th International Conference of Phospholipase A2 Mediated Signaling in Translational Medicine.
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Emerging roles of secreted phospholipase A2s.2013

    • Author(s)
      Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K.
    • Organizer
      FASEB Summer Research Conference on Lysophospholipids and Other Related Mediators.
    • Place of Presentation
      ニセコ
    • Related Report
      2013 Annual Research Report
  • [Presentation] sPLA2の新しいパラダイム.2013

    • Author(s)
      村上誠、武富芳隆、佐藤弘泰、三木寿美、山本圭.
    • Organizer
      第86回日本生化学会.
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] リン脂質代謝異常と生活習慣病.2013

    • Author(s)
      村上誠.
    • Organizer
      フォーラム2013衛生薬学環境トキシコロジー.
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脂質メディエーターの観点から捉えた慢性炎症と肥満症.2013

    • Author(s)
      村上誠、佐藤弘泰、武富良隆.
    • Organizer
      第34回日本肥満学会.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] DEFining the biological functions of DEF of group II sPLA2s.2013

    • Author(s)
      Murakami M.
    • Organizer
      The 13th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases.
    • Place of Presentation
      San Juan, Puerto Rico
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel insights into sPLA2s in health and disease.2013

    • Author(s)
      Murakami M.
    • Organizer
      The 16th GEM-10th GERLI meeting: from membranes to pathologies.
    • Place of Presentation
      Saint-Jean Cap Ferrat, France
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンとマスト細胞.2013

    • Author(s)
      村上誠、武富芳隆.
    • Organizer
      第63回日本アレルギー学会.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 全身性代謝応答を制御するリゾホスホリパーゼ2013

    • Author(s)
      村上誠
    • Organizer
      第133会日本薬学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] sPLA2s in skin biology.2012

    • Author(s)
      Murakami M.
    • Organizer
      The 1st International Conference of Lipid Mediators.
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 油はなぜ体に必要か?脂質代謝酵素のノックアウトマウスから脂質シグナリングの重要性を考える.2012

    • Author(s)
      村上誠
    • Organizer
      第26回モロシヌス研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] sPLA2とメタボリックシンドローム2012

    • Author(s)
      村上誠
    • Organizer
      第33回日本炎症再生医学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Novel roles of phospholipase A2 enzymes and lipid machineries in allergic inflammation.2012

    • Author(s)
      Murakami M, Taketomi Y, Yamamoto K.
    • Organizer
      International Symposium “Allergy and Inflammation”
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細胞外リン脂質環境を制御するsPLA2群のバイオロジー2012

    • Author(s)
      村上誠
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規リゾホスホリパーゼによるGPC産生経路の生理的意義2012

    • Author(s)
      平林哲也、村上誠
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Secreted phospholipase A_2s in reproduction2011

    • Author(s)
      Ushida, A., Murakami, M.
    • Organizer
      The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Secreted phospholipase A_2s in skin homeostasis2011

    • Author(s)
      Yamamoto, K., Murakami, M.
    • Organizer
      The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Secreted phospholipase A_2s in anaphylaxis2011

    • Author(s)
      Taketomi, Y., Murakami, M.
    • Organizer
      The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Secreted phospholipase A_2s in metabolic syndrome2011

    • Author(s)
      Sato, H., Murakami, M.
    • Organizer
      The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Secreted phospholipase A_2s in atopic dermatitis2011

    • Author(s)
      Shimo, K., Murakami, M.
    • Organizer
      The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Searching the secrets of secreted phospholipase A_2s2011

    • Author(s)
      Murakami, M.
    • Organizer
      The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルギー応答を制御する新しい脂質ネットワーク2011

    • Author(s)
      村上誠、武富芳隆
    • Organizer
      第61回日本アレルギー学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Secreted Phospholipase A_2 in epidermal differentiation, acidification, and barrier function2011

    • Author(s)
      Murakami, M., Yamamoto, K.
    • Organizer
      The 8^<th> GERLI Lipidomics meeting
    • Place of Presentation
      Lyon, France(招待講演)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin2011

    • Author(s)
      Yamamoto, K., Murakami, M.
    • Organizer
      The 8^<th> GERLI Lipidomics meeting
    • Place of Presentation
      Lyon, France
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] sPLA_2-IIDは抗炎症性脂質の産生を制御して炎症応答の寛解に関与する2011

    • Author(s)
      三木寿美、村上誠
    • Organizer
      ファーマ・バイオフォーラム2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内II型PAFアセチルハイドロラーゼマスト細胞における機能解析2011

    • Author(s)
      嶋中雄太、村上誠、新井洋由
    • Organizer
      ファーマ・バイオフォーラム2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 皮脂腺に特異的に発現する新規脂質代謝酵素の機能解析2011

    • Author(s)
      平林哲也、村上誠
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] PGE_2-EP3受容体シグナルはマスト細胞の活性化を介して炎症を惹起する2011

    • Author(s)
      森本和志、村上誠、杉本幸彦
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 好酸球性膿疱性毛包炎におけるPGD_2の役割の解明2011

    • Author(s)
      中東恭子、村上誠、椛島健次
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 皮膚病態生理における分泌性ホスホリパーゼA_2の機能2011

    • Author(s)
      山本圭、村上誠
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] アトピー性皮膚炎モデルにおける分泌性ホスホリパーゼA_2分子群の機能解析2011

    • Author(s)
      下華奈子、村上誠
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] X型分泌性ホスホリパーゼA_2の消化、神経機能、体毛形成における新規機能2011

    • Author(s)
      佐藤弘泰、村上誠
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] X型分泌性ホスホリパーゼA_2の生殖における新規機能2011

    • Author(s)
      牛田絢子、村上誠
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] ホスファチジルエタノールアミンは破骨細胞融合に関与する2011

    • Author(s)
      入江敦、山本圭、村上誠
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内II型PAFアセチルヒドラーゼのマスト細胞における機能解析2011

    • Author(s)
      嶋中雄太、村上誠、新井洋由
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Getting new insights into the functions of sPLA_2s2011

    • Author(s)
      Murakami, M.
    • Organizer
      The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] マスト細胞を制御する新しい脂質マシナリー2011

    • Author(s)
      武富芳隆、村上誠
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] An adipokine-like phospholipase A_2 from hypertrophied adipocytes controls lipid metabolism and obesity2011

    • Author(s)
      Sato, H., Murakami, M.
    • Organizer
      The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Group IIF phospholipase A_2 maintains epidermal homeostasis2011

    • Author(s)
      Yamamoto, K., Murakami, M.
    • Organizer
      The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phospholipase A_2s in adiposity and metabolic syndrome2011

    • Author(s)
      Murakami, M.
    • Organizer
      The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
    • Place of Presentation
      札幌(招待講演)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of multiple sPLA_2 enzymes in obesity, hepatic steatosis, insulin tolerance, lipoprotein metabolism and adipose inflammation2011

    • Author(s)
      Sato, H., Murakami, M.
    • Organizer
      The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Metabolic pathways regulating formation and composition of lipid droplets in sebocytes2011

    • Author(s)
      Hirabayashi, T., Murakami, M.
    • Organizer
      The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 外根鞘に局在するsPLA_2-Xは体毛の恒常性維持に関与する2011

    • Author(s)
      山本圭、村上誠
    • Organizer
      第53回脂質生化学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 樹状細胞のsPLA_2-IIDは炎症応答の寛解を制御する2011

    • Author(s)
      三木寿美、村上誠
    • Organizer
      第53回脂質生化学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪過栄養により誘導されるsPLA_2-Vは全身的な脂質代謝異常を制御する2011

    • Author(s)
      佐藤弘泰、村上誠
    • Organizer
      第53回脂質生化学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分泌性ホスホリパーゼA_2と循環器疾患2011

    • Author(s)
      村上誠
    • Organizer
      日本薬学会
    • Place of Presentation
      静岡(招待講演)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホスホリパーゼA_2による精子成熟と活性化の制御2011

    • Author(s)
      佐藤弘泰、原俊太郎、村上誠
    • Organizer
      日本薬学会
    • Place of Presentation
      静岡(招待講演)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] New insights into the functions of secreted phospholipase A_2s2010

    • Author(s)
      村上誠
    • Organizer
      BMB2010
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホスホリパーゼA_2研究における脂質メタボロームの応用展開2010

    • Author(s)
      村上誠
    • Organizer
      ホスファチジルセリン研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分泌性ホスホリパーゼA_2による生命応答の制御2010

    • Author(s)
      村上誠
    • Organizer
      東大脂質談話会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂質メタボロミクスの応用展開:ホスホリパーゼA_2と生活習慣病2010

    • Author(s)
      村上誠
    • Organizer
      日本医用マススペクトル学会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] sPLA_2の新展開:アレルギー、メタボリックシンドロームにおける新しい機能2010

    • Author(s)
      村上誠
    • Organizer
      武田薬品特別シンポジウム
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Secreted phospholipase A_2, lipid mediators, and immunity2010

    • Author(s)
      Murakami, M., Taketomi, Y., Yamamoto, K.
    • Organizer
      14^<th> International Congress of Inflammation
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Emerging roles of secreted phospholipase A_2 in atherosclerosis and metabolic disorders2010

    • Author(s)
      村上誠
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      岐阜(招待講演)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Solving the secrets of secreted phospholipase A_2s2010

    • Author(s)
      Murakami, M
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Steamboat Springs, USA(招待講演)
    • Year and Date
      2010-06-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biological functions of sPLA_2s2010

    • Author(s)
      Murakami, M
    • Organizer
      Keystone Symposia
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] PLA2を起点とした脂質ネットワークによるアレルギー制御.

    • Author(s)
      武富良隆. 村上誠.
    • Organizer
      第12回ホスファチジルセリン研究会.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2分子ファミリーの機能.

    • Author(s)
      村上誠.
    • Organizer
      第11回心血管先端医療フォーラム.
    • Place of Presentation
      甲府
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2と疾患.

    • Author(s)
      村上誠.
    • Organizer
      第3回都医学研シンポジウム.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2分子ファミリーの機能:皮膚の病態生理との関わり.

    • Author(s)
      村上誠.
    • Organizer
      名古屋大学皮膚科セミナー講演会.
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] リン脂質代謝異常とメタボリックシンドローム.

    • Author(s)
      村上誠.
    • Organizer
      第3回Metabolism Scientific Forum.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脂質メディエーターによるアレルギー制御.

    • Author(s)
      武富芳隆, 村上誠.
    • Organizer
      第77回日本皮膚科学会東京支部学術大会.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脂質メディエーターの新機軸.

    • Author(s)
      村上誠、武富芳隆.
    • Organizer
      第25回鹿児島呼吸器内科セミナー.
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] リン脂質代謝酵素ホスホリパーゼA2による生命応答制御の新基軸.

    • Author(s)
      村上誠.
    • Organizer
      順天堂大学アトピー疾患研究センター研究プロジェクト評価会議.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] sPLA2群のバイオロジー

    • Author(s)
      村上誠
    • Organizer
      第23回フォーラム・イン・ドージン
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Bioactive Lipid Mediators: Current Reviews and Protocols2015

    • Author(s)
      Yokomizo T. and Murakami, M.
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学増刊ー脂質疾患学2015

    • Author(s)
      村上誠、横溝岳彦
    • Publisher
      秀潤社
    • Related Report
      2014 Annual Research Report
  • [Book] 遺伝子医学MOOK: 最新生理活性脂質研究ー実験手法、基礎的知識とその応用2013

    • Author(s)
      横溝岳彦、青木淳賢、杉本幸彦、村上誠
    • Total Pages
      304
    • Publisher
      メディカルドウ
    • Related Report
      2013 Annual Research Report
  • [Book] Phospholipase A_2 and lipid mediators2010

    • Author(s)
      Lambeau, G.Murakami, M
    • Total Pages
      728
    • Publisher
      Biochimie Special Issue(Elsevier)
    • Related Report
      2010 Annual Research Report
  • [Remarks] 脂肪細胞から分泌されるリン脂質分解酵素PLA2G5とPLA2G2Eは肥満において異なる役割を担う

    • URL

      http://first.lifesciencedb.jp/archives/8936#more-8936

    • Related Report
      2014 Annual Research Report
  • [Remarks] 脂肪細胞から分泌される脂質代謝酵素による肥満の新しい調節機構の発見

    • URL

      http://www.jst.go.jp/pr/announce/20140606/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 脂肪細胞から分泌される脂質代謝酵素による肥満の新しい調節機構の発見

    • URL

      http://www.igakuken.or.jp/topics/2014/0606.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] マスト細胞の成熟経路の発見

    • URL

      http://www.igakuken.or.jp/lipid/reseacch8.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 体に優しい脂質を働かせ、炎症にブレーキをかける酵素の同定

    • URL

      http://www.igakuken.or.jp/lipid/research9.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.rinshoken.or.jp/P/publication_j.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.rinshoken.or.jp/P/index_japanese.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 皮膚バリア機能促進剤のスクリーニング方法2014

    • Inventor(s)
      村上誠、平林哲也
    • Industrial Property Rights Holder
      村上誠、平林哲也
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-116066
    • Filing Date
      2014-06-04
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] ホスホリパーゼA2G3を指標としたスクリーニング方法2014

    • Inventor(s)
      村上 誠、武富 芳隆
    • Industrial Property Rights Holder
      村上 誠、武富 芳隆
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-073775
    • Filing Date
      2014-03-29
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] PLA2G2Fを指標とした表皮角化細胞の過増殖性疾患に対する薬剤のスクリーニング方法2013

    • Inventor(s)
      村上誠、山本圭
    • Industrial Property Rights Holder
      村上誠、山本圭
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-21
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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