| Budget Amount *help |
¥137,540,000 (Direct Cost: ¥105,800,000、Indirect Cost: ¥31,740,000)
Fiscal Year 2014: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2013: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2012: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2011: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2010: ¥30,290,000 (Direct Cost: ¥23,300,000、Indirect Cost: ¥6,990,000)
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| Outline of Final Research Achievements |
Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze the sn-2 position of phospholipids to generate fatty acids and lysophospholipids. Mammalian genomes encode genes for more than 30 PLA2s or related enzymes, which are subdivided into several groups on the basis of their structures and enzymatic properties. In this study, we used transgenic and knockout mice for various PLA2s in combination with lipidomic analyses to decipher their pathophysiological roles and underlying lipid pathways in various pathophysiological events. From this approach, we successfully identified the novel roles of secreted PLA2s in mast cell maturation and allergy (PLA2G3), resolution of contact hypersensitivity (PLA2G2D), metabolic syndrome (PLA2G5 and PLA2G2E), sperm maturation and fertility (PLA2G3 and PLA2G10), and so on. Overall, this study reveal that the sPLA2 family affects various biological events by modulating extracellular phospholipid milieus in response to given microenvironmental cues.
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