| Budget Amount *help |
¥310,700,000 (Direct Cost: ¥239,000,000、Indirect Cost: ¥71,700,000)
Fiscal Year 2014: ¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
Fiscal Year 2013: ¥56,680,000 (Direct Cost: ¥43,600,000、Indirect Cost: ¥13,080,000)
Fiscal Year 2012: ¥54,080,000 (Direct Cost: ¥41,600,000、Indirect Cost: ¥12,480,000)
Fiscal Year 2011: ¥56,550,000 (Direct Cost: ¥43,500,000、Indirect Cost: ¥13,050,000)
Fiscal Year 2010: ¥93,210,000 (Direct Cost: ¥71,700,000、Indirect Cost: ¥21,510,000)
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| Outline of Final Research Achievements |
1. p47 inhibits NF-kB activation by inducing degradation of NEMO in lysosome. 2. NF-kB activation by HTLV-1 Tax protein requires generation of K63-linked polyubiquitin chains. 3. NF-kB activation in non-cancer stem cells induces expression of JAG1, which in turn stimulates cancer stem cells to increase stem cell population. NF-kB activation also induces expression of TMOD1, which leads to induction of MMP13, a protease that degrades extracellular matrix. 4. RelB-Venus knock-in mice is a tool to analyze spatiotemporal regulation of RelB.
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