| Budget Amount *help |
¥168,740,000 (Direct Cost: ¥129,800,000、Indirect Cost: ¥38,940,000)
Fiscal Year 2014: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2013: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Fiscal Year 2012: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2011: ¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
Fiscal Year 2010: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
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| Outline of Final Research Achievements |
In human cells, a wide array of extracellular stimuli generates intracellular signals that converge on a limited number of protein kinase cascades, commonly referred to as mitogen-activated protein kinase (MAPK) pathways. MAPK cascades, which consist of a three-tiered core of protein kinases, are the major signaling systems that dictate cell fate decisions such as survival, proliferation, and apoptosis. There are at least three subfamilies of MAPKs, named p38, JNK, and ERK. Perturbation of these cellular signaling systems is involved in a variety of life-threatening diseases. Therefore, these signaling systems are of clinical importance. In this study, we identified: 1) The ERK pathway is regulated at least in part by protein sumoylation and O-GlcNAcylation ; 2) MCRIP1, a novel ERK substrate, regulates epithelial-mesenchymal transition; 3) Oscillation of the p38/JNK activities in cells is critical for the regulation of the immune response.
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