| Budget Amount *help |
¥133,640,000 (Direct Cost: ¥102,800,000、Indirect Cost: ¥30,840,000)
Fiscal Year 2014: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2013: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2012: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2011: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2010: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
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| Outline of Final Research Achievements |
NF-κB is a critical signal transduction pathway to regulate immune and inflammatory responses, which are induced by various stimuli such as bacterial and viral infections and irradiation. We identified a novel physiological regulatory mechanism that is mediated by linearly linked ubiquitin molecules. We showed that genetic deficiency of a component of linear ubiquitin-generating enzyme (LUBAC) induces severe chronic dermatitis. Furthermore, we revealed that LUBAC activity is related with B cell lymphomas.
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