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Structural basis for protein posttranscriptional modifications and cellular signaling

Planned

Project AreaRegulation of signal transduction by post-translational modifications and its pathogenic dysregulation
Project/Area Number 22117007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

ISHITANI Ryuichiro  東京大学, 理学(系)研究科(研究院), 准教授 (90361568)

Co-Investigator(Kenkyū-buntansha) 濡木 理  東京大学, 理学(系)研究科(研究院), 教授 (10272460)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥125,450,000 (Direct Cost: ¥96,500,000、Indirect Cost: ¥28,950,000)
Fiscal Year 2014: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2013: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2012: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2011: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
KeywordsX線結晶構造解析 / タンパク質翻訳後修飾 / 細胞内シグナル伝達 / NF-κBシグナル伝達経路 / TGF-βシグナル伝達経路
Outline of Final Research Achievements

Post-translational modifications play critical roles in the regulation of signal transduction and cellular functions. Structural biology methods, including X-ray crystallography, are powerful tools for dissecting the molecular interaction mechanisms between the factors involved in these signaling pathways. Therefore, synergetic approaches by structural, molecular and cellular biology are important to understand both the mechanisms of signal transduction by post-translational modifications and their pathogenic dysregulation. Our results of the structural analyses of cGAS, A20-ZF7-linear ubiquitine complex, and HHM highlight the importance of synergetic approaches by collaborations between different biological fields.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(50 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Remarks

  • [Journal Article] Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter2015

    • Author(s)
      Lee Y, Nishizawa T, Yamashita K, Ishitani R, Nureki O
    • Journal Title

      Nat Commun

      Volume: 6 Pages: 6112-6112

    • DOI

      10.1038/ncomms7112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase.2014

    • Author(s)
      Kumazaki, K., Kishimoto, T., Furukawa, A., Mori, H., Tanaka, Y., Dohmae, N., Ishitani, R., Tsukazaki, T., and Nureki, O.
    • Journal Title

      Scientific Reports 4

      Volume: 4 Pages: 7299-7299

    • DOI

      10.1038/srep07299

    • NAID

      120005716851

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE2014

    • Author(s)
      Takeda H, Hattori M, Nishizawa T, Yamashita K, Shah ST, Caffrey M, Maturana AD, Ishitani R, Nureki O
    • Journal Title

      Nat. Commun.

      Volume: 5 Pages: 5374-5374

    • DOI

      10.1038/ncomms6374

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation2014

    • Author(s)
      Kobayashi K, Katz A, Rajkovic A, Ishii R, Branson OE, Freitas MA, Ishitani R, Ibba M, Nureki O
    • Journal Title

      Nucleic Acids Res

      Volume: 42 Pages: 12295-12305

    • DOI

      10.1093/nar/gku898

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystallization and preliminary X-ray crystallographic analysis of YfcM: an important factor for EF-P hydroxylation2014

    • Author(s)
      Kobayashi K, Suzuki T, Dohmae N, Ishitani R, Nureki O
    • Journal Title

      Acta Crystallogr F Struct Biol Commun

      Volume: 70 Pages: 1236-1239

    • DOI

      10.1107/s2053230x14015726

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans2014

    • Author(s)
      Kumazaki, K., Tsukazaki, T., Nishizawa, T., Tanaka, Y., Kato, H.E., Nakada-Nakura, Y., Hirata, K., Mori, Y., Suga, H., Dohmae, N., Ishitani, R. and Nureki, O.
    • Journal Title

      Acta Crystallographica Section F

      Volume: 70 Pages: 1056-1060

    • DOI

      10.1107/s2053230x14012540

    • NAID

      120005716852

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP2014

    • Author(s)
      Tominaga T, Kobayashi K, Ishii R, Ishitani R, Nureki O
    • Journal Title

      Acta Crystallogr F Struct Biol Commun

      Volume: 70 Pages: 1009-1014

    • DOI

      10.1107/s2053230x14014046

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp6.2014

    • Author(s)
      Morita J, Kato K, Mihara E, Ishitani R, Takagi J, Nishimasu H, Aoki J, Nureki O
    • Journal Title

      Acta Crystallogr. F Struct. Biol. Commun.

      Volume: 70 Pages: 794-799

    • DOI

      10.1107/s2053230x14008929

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structure of a claudin provides insight into the architecture of tight junctions.2014

    • Author(s)
      Suzuki H, Nishizawa T, Tani K, Yamazaki Y, Tamura A, Ishitani R, Dohmae N, Tsukita S, Nureki O, Fujiyoshi Y
    • Journal Title

      Science.

      Volume: 344 Pages: 303-307

    • DOI

      10.1126/science.1248571

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis for Sec-independent membrane protein insertion by YidC2014

    • Author(s)
      Kumazaki, K., Chiba, S., Takemoto, M., Furukawa, A., Nishiyama, K., Sugano, Y., Mori, T., Dohmae, N., Hirata, K., Nakada-Nakura, Y., Maturana, A.D., Tanaka, Y., Mori, H., Sugita, Y., Arisaka, F., Ito K., Ishitani, R., Tsukazaki, T. and Nureki, O.
    • Journal Title

      Nature

      Volume: 509 Pages: 516-20

    • DOI

      10.1038/nature13167

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases2014

    • Author(s)
      Araiso Y, Huot JL, Sekiguchi T, Frechin M, Fischer F, Enkler L, Senger B, Ishitani R, Becker HD, Nureki O
    • Journal Title

      Nucleic Acids Res

      Volume: 42 Pages: 6052-6063

    • DOI

      10.1093/nar/gku234

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change2014

    • Author(s)
      Yamagata, K., Goto, Y., Nishimasu, H., Morimoto, J., Ishitani, R., Dohmae, N., Takeda, N., Nagai, R., Komuro, I., Suga, H., Nureki, O
    • Journal Title

      Structure

      Volume: 22 Pages: 345-352

    • DOI

      10.1016/j.str.2013.12.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger.2014

    • Author(s)
      Nishizawa T, Kita S, Maturana AD, Furuya N, Hirata K, Kasuya G, Ogasawara S, Dohmae N, Iwamoto T, Ishitani R, Nureki O
    • Journal Title

      Science

      Volume: 341 Pages: 168-172

    • DOI

      10.1126/science.1239002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe2014

    • Author(s)
      Mitsuyasu Kawaguchi
    • Journal Title

      ACS Chem Biol

      Volume: 8 Pages: 1713-1721

    • DOI

      10.1021/cb400150c

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural and functional analyses of DNA-sensing and immune activation by human cGAS.2013

    • Author(s)
      Kazuki Kato, Ryohei Ishii, Eiji Goto, Ryuichiro Ishitani, Fuminori Tokunaga, and Osamu Nureki
    • Journal Title

      PLoS One

      Volume: 8

    • DOI

      10.1371/journal.pone.0076983

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT"2013

    • Author(s)
      Doki, S., Kato, H. E., Solcan, N., Iwaki, M., Koyama, M., Iwase, N., Tsukazaki, T., Sugita, Y., Kandori, H., Newstead, S., Ishitani, R., and Nureki, O.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Pages: 11343-11348

    • DOI

      10.1073/pnas.1301079110

    • NAID

      130003391407

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.2013

    • Author(s)
      Y・ Tanaka, C・J・ Hipolito, A・D・ Maturana, K・ Ito, T・ Kuroda, T・ Higuchi, T・ Katoh, H・E・ Kato, M・ Hattori, K・ Kumazaki, T・ Tsukazaki, R・ Ishitani, H・ Suga, O・ Nureki
    • Journal Title

      Nature

      Volume: 496 Pages: 247-251

    • DOI

      10.1038/nature12014

    • NAID

      120005716854

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm.2013

    • Author(s)
      K. Nozawa, R. Ishitani, T. Yoshihisa, M. Sato, F. Arisaka, S. Kanamaru, N. Dohmae, D. Mangroo, B. Senger, H. D. Becker and O. Nureki
    • Journal Title

      Nucleic Acids Res.

      Volume: 41 Pages: 3901-14

    • DOI

      10.1093/nar/gkt010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the novel mechanism of drug extrusion by a MATE multidrug transporter2013

    • Author(s)
      Hiroshi Nishimasu, Hirotsugu Ishizu
    • Journal Title

      Nature

      Volume: 491 Pages: 284-284

    • DOI

      10.1038/nature11509

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Zucchini from Drosophila melanogaster2012

    • Author(s)
      Fukuhara S, Nishimasu H, Bonnefond L, Matsumoto N, Ishitani R, Nureki O
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun

      Volume: F68 Pages: 1346-1346

    • DOI

      10.1107/s1744309112038936

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin2012

    • Author(s)
      Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Pages: 16876-16876

    • DOI

      10.1073/pnas.1208017109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular dynamics simulation of Autotaxin : roles of the nuclease-like domain and the glycan modification2012

    • Author(s)
      Michio Koyama, Hiroshi Nishimasu, Ryuichiro Ishitani, Osamu Nureki
    • Journal Title

      J Phys Chem B

      Volume: 116 Pages: 11798-11798

    • DOI

      10.1021/jp303198u

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.2012

    • Author(s)
      Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O
    • Journal Title

      EMBO J

      Volume: 31 Pages: 3856-3856

    • DOI

      10.1038/emboj.2012.241

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for translation termination by archaeal RF1 an GTP-bound EF1α complex.2012

    • Author(s)
      Kan Kobayashi, Kazuki Saito, Ryuichiro Ishitani, Koichi Ito, Osamu Nureki
    • Journal Title

      Nucleic Acids Res

      Volume: 40 Pages: 9319-28

    • DOI

      10.1093/nar/gks660

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp12012

    • Author(s)
      Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
    • Journal Title

      Acta Crystallographica Section F

      Volume: F68 Pages: 778-778

    • DOI

      10.1107/s1744309112019306

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of a dominant-negative helix-loop-helix tran- scriptional regulator suggests mechanisms of autoinhibition2012

    • Author(s)
      Ishii R
    • Journal Title

      EMBO J.

      Volume: 31 Pages: 2541-2552

    • DOI

      10.1038/emboj.2012.77

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the channelrhodops in light-gated cation channel2012

    • Author(s)
      Hideaki E.Kato, Feng Zhang, Ofer Yizhar, Charu Ramakrishnan, Tomohiro Nishizawa, Kunio Hirata, Jumpei Ito, Yusuke Aita, Tomoya Tsukazaki, Shigehiko Hayashi, Peter Hegemann, Andres D.Maturana, Ryuichiro Ishitani, Karl Deisseroth, Osamu Nureki
    • Journal Title

      Nature

      Volume: 482 Pages: 369-374

    • DOI

      10.1038/nature10870

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 3D view of autotaxin2012

    • Author(s)
      Nishimasu H, Ishitani R, Aoki J, Nureki O
    • Journal Title

      Trends Pharmacol Sci.

      Volume: 33 Pages: 138-145

    • DOI

      10.1016/j.tips.2011.12.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray diffraction of the first periplasmic domain of SecDF, a translocon-associated membrane protein, from Thermus thermophilus2011

    • Author(s)
      Echizen Y, Tsukazaki T, Dohmae N, Ishitani R, Nureki O
    • Journal Title

      Acta Cryst.

      Volume: F67 Pages: 376-380

    • DOI

      10.1107/s1744309106007779

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and function of a membrane component SecDF that enhances protein exportStructure and function of a membrane component SecDF that enhances protein export.2011

    • Author(s)
      Tsukazaki, T., et al
    • Journal Title

      Nature

      Volume: 475 Pages: 235-238

    • DOI

      10.1038/nature09980

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators2011

    • Author(s)
      Nishimasu H, 他, Ishitani R, Takagi J, Aoki J, Nureki O
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 18 Pages: 205-212

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog2011

    • Author(s)
      Bonnefond L, (他), Ishitani R, Nureki O.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 3912-3917

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Omnipotent role of archaeal elongation factor 1 alpha (EF1α) in translational elongation and termination, and quality control of protein synthesis.2010

    • Author(s)
      Saito K, Kobayashi K, (他), Ishitani R, Nureki O, Ito K
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Pages: 19242-19247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification2010

    • Author(s)
      Kato M, (他), Ishitani R, Nureki O
    • Journal Title

      Nucleic Acids Res

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex2010

    • Author(s)
      Kobayashi K, (他), Ishitani R, Inada T, Nureki O
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Pages: 17575-17579

    • NAID

      10030494636

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-terminal domain of archaeal O-phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNASec2010

    • Author(s)
      Sherrer RL, (他), Ishitani R, Ho JM, Soll D, Nureki O
    • Journal Title

      Nucleic Acids Res

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expanding role of the Jumonji C domain as an RNA hydroxylase2010

    • Author(s)
      Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 34503-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of an archaeal non-discriminating glutamyl-tRNA synthetase : a missing link in the evolution of Gln-tRNAGln formation2010

    • Author(s)
      Nureki O, (他), Ishitani R
    • Journal Title

      Nucleic Acids Res

      Volume: 38 Pages: 7286-7297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms underlying the early stage of protein translocation through the Sec translocon2010

    • Author(s)
      Mori T, Ishitani R, Tsukazaki T, Nureki O, Sugita Y
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 945-950

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 先端放射光を用いたチャネル・トランスポーターの高分解能構造解析と分子機構の解明2015

    • Author(s)
      石谷隆一郎
    • Organizer
      日本放射光学会
    • Place of Presentation
      草津市,滋賀
    • Year and Date
      2015-01-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 炎症応答に関わる因子とその機能をモデュレートする化合物の構造生物学 ― Cyclic GMP-AMP合成酵素の結晶構造 ―2014

    • Author(s)
      石谷隆一郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市,神奈川
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 炎症応答に関わる因子の構造生物学 Cyclic GMP-AMP合成酵素の結晶構造2014

    • Author(s)
      石谷隆一郎
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都市左京区,京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Crystal structure of channelrhodopsin ― a light-gated cation channel ―2014

    • Author(s)
      石谷隆一郎
    • Organizer
      16th International Congress on Photobiology
    • Place of Presentation
      Universidad Nacional de Cordoba,Argentina
    • Year and Date
      2014-09-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Crystal structure of YidC reveals a membrane protein insertion mechanism2014

    • Author(s)
      Ryuichiro Ishitani
    • Organizer
      Gordon Research Conference on Ligand recognition & molecular gating
    • Place of Presentation
      Ventura CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] シグナル伝達にかかわる因子Autotaxinの構造ベース創薬2014

    • Author(s)
      石谷隆一郎
    • Organizer
      日本薬学会
    • Place of Presentation
      熊本市、熊本県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex2013

    • Author(s)
      Ryuichiro Ishitani
    • Organizer
      EMBO Conference "Eukaryotic RNA Turnover: From Structural Insights to Diseases"
    • Place of Presentation
      Strasbourg, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] 最先端のマイクロビームラインと計算機シミュレーションを用いた膜輸送体の構造生物学2013

    • Author(s)
      石谷隆一郎
    • Organizer
      蛋白質科学会
    • Place of Presentation
      鳥取市、鳥取県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 古細菌由来Pelota・EF1α・GTP複合体によるmRNA品質管理機構の構造基盤2010

    • Author(s)
      石谷隆一郎
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Book] 酵素利用技術大系-基礎・解析から改変・高機能化・産業利用まで-(1章1節2)2010

    • Author(s)
      石谷隆一郎、荒磯裕平、野澤佳世
    • Total Pages
      800
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nurekilab.net/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-22   Modified: 2019-07-29  

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