| Budget Amount *help |
¥251,550,000 (Direct Cost: ¥193,500,000、Indirect Cost: ¥58,050,000)
Fiscal Year 2014: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Fiscal Year 2013: ¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
Fiscal Year 2012: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2011: ¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000)
Fiscal Year 2010: ¥59,800,000 (Direct Cost: ¥46,000,000、Indirect Cost: ¥13,800,000)
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| Outline of Final Research Achievements |
This project aimed to clarify molecular mechanisms that regulate lineage determination steps taking place during developmental process from multipotent hematopoietic progenitors to unipotent T cell progenitors. By using in vitro on/off differentiation culture system, we disclosed that transcription factor Bcl11b works as a master regulator of T cell lineage determination（Science, 2010）. The data on the time course sample of in vitro T cell differentiation was published as a part of Riken FANTOM5 project （Science, 2015）. We further found that by conditionally inactivating polycomb function in T cell lineage, T cell progenitors were converted to B cell lineage (submitted). Thus, we have succeeded in revealing transcriptional and epigenetic mechanisms of T cell lineage determination.
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