| Budget Amount *help |
¥290,940,000 (Direct Cost: ¥223,800,000、Indirect Cost: ¥67,140,000)
Fiscal Year 2014: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2013: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2012: ¥66,170,000 (Direct Cost: ¥50,900,000、Indirect Cost: ¥15,270,000)
Fiscal Year 2011: ¥56,030,000 (Direct Cost: ¥43,100,000、Indirect Cost: ¥12,930,000)
Fiscal Year 2010: ¥81,380,000 (Direct Cost: ¥62,600,000、Indirect Cost: ¥18,780,000)
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| Outline of Final Research Achievements |
We pursued structural studies of signaling protein complexes important in cell biology of mammalian and plant cells. Using X-ray crystallography, we revealed three-dimensional structures of the PHCCEx domain of RacGEF Tiam1, the cargo-recognition domain of myosin-X and mechano-sensing domain of a-catenin. We also determined the structures of medically important complexes, the trimeric G protein Gq-YM254890, merlin-DCAF-1 and thalidomide-celeblon complexes. Our contribution to plant biology is based on our structure determination of receptors of newly-established hormones, strigolactone and karrikin receptors.
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