| Budget Amount *help |
¥220,740,000 (Direct Cost: ¥169,800,000、Indirect Cost: ¥50,940,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2012: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2011: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2010: ¥97,370,000 (Direct Cost: ¥74,900,000、Indirect Cost: ¥22,470,000)
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| Outline of Final Research Achievements |
Eukaryotic cells are composed of various organelles, which are compartmentalized by lipid bilayer. Therefore, transport between spatially separated organelles is mediated by membrane vesicles. Vesicular transports play critical roles in cellular processes including cell motility, deformation and polarization. In this research project, we revealed some of the regulatory mechanisms for vesicular transport at the atomic resolution level by X-ray crystallography of molecular complexes that are involved in vesicular transport. Moreover, technology platform that has been developed through this project was applied to collaborative researches to elucidate protein complex-mediated regulatory mechanisms for other cellular functions.
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