| Budget Amount *help |
¥109,720,000 (Direct Cost: ¥84,400,000、Indirect Cost: ¥25,320,000)
Fiscal Year 2014: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2011: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2010: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
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| Outline of Final Research Achievements |
In this study we conducted cellular and molecular analyses on neuro-vascular interactions in the development of the enteric nervous system (ENS). By performing live-cell imaging of enteric neural progenitors and vasculature in mice, we examined cell behavior in developing ENS. We have discovered that a subset of enteric neural progenitors crosses the mesentery when the small and large intestines are juxtaposed to each other during development. Trans-mesenteric enteric neural progenitors are the principal source of the ENS in the colon, and impaired trans-mesenteric migration delays colonization of the colon by enteric neural progenitors. Moreover, trans-mesenteric enteric progenitors are reduced in a mouse model of Hirschsprung disease (HSCR: congenital absence of the ENS in the distal gut), suggesting a potential involvement of impaired trans-mesenteric migration in HSCR pathogenesis. We have also discovered that GDNF is one of the molecules that regulate trans-mesenteric migration.
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