| Budget Amount *help |
¥110,500,000 (Direct Cost: ¥85,000,000、Indirect Cost: ¥25,500,000)
Fiscal Year 2014: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2011: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2010: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Outline of Final Research Achievements |
To elucidate the molecular mechanisms by which extracellular matrices regulate neuro-vascular interactions, we conducted (1) comprehensive identification of the specific ligand(s) for αVβ8 integrin, which play an important role in the formation of blood-brain barrier; and (2) functional characterization of a specialized basement membrane “fractone” in neural stem cell niche. We found that (1) TGF-β1 is the specific ligand for αVβ8 integrin, and (2) fractones are produced by neural stem cells. These results will unravel the cell-adhesive machinery that regulates the neuro-vascular interactions.
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