| Budget Amount *help |
¥108,290,000 (Direct Cost: ¥83,300,000、Indirect Cost: ¥24,990,000)
Fiscal Year 2014: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2011: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2010: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
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| Outline of Final Research Achievements |
Post-mitotic neurons are generated from neural progenitor cells (NPCs) at the expense of their proliferation. We showed that post-mitotic neurons are produced only from neural progenitor cells that divide in the sub-ventricular zone (SVZ). We also showed that this neurogenesis depends on Neuregulin 1 type II (NRG1-II)-ErbB signaling. Moreover, we developed a novel fluorescent probe, which enables us to monitor the activity of the NRG1 ecotodomain shedding. Expression of the probe in zebrafish embryos revealed involvement of the NRG1 ecotodmain shedding in the spatio-temporal regulations of its signaling. We also elucidated novel roles of ADAM8 and ADAM19 in mice and ADAM12 in growth of zebrafish.
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