| Budget Amount *help |
¥116,220,000 (Direct Cost: ¥89,400,000、Indirect Cost: ¥26,820,000)
Fiscal Year 2014: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2013: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2012: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2011: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2010: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
|
|---|
| Outline of Final Research Achievements |
Embryonic neural stem cells give rise to various types of neurons first and glial cells later. Thus, embryonic neural stem cells change their competency during development, but the detailed mechanism is not known. We found that in multipotent neural stem cells, multiple fate determination factors are expressed in an oscillatory manner, and that the expression of the histone methyl transferase ESET, which regulates neuronal and glial gene expression, gradually decreases during development. Because the ESET gene promoter contains multiple binding sites for Hes1, one of the fate determination factors, it was suggested that Hes1 oscillation regulates temporal changes of competency of neural stem cells via ESET expression.
|
