| Budget Amount *help |
¥109,720,000 (Direct Cost: ¥84,400,000、Indirect Cost: ¥25,320,000)
Fiscal Year 2014: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2013: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2012: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2011: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2010: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Outline of Final Research Achievements |
One of the fundamental questions in understanding tissue development is how multipotent progenitors/tissue stem cells give rise to various cell types in a defined order to achieve appropriate tissue organization. Neural stem/progenitor cells (NPCs) attract much attention since these cells give rise to neuronal and glial cell types in a developmental-stage dependent manner with striking precision. We have shown in this study that polycomb group (PcG) complex and high mobility group A (HMGA) proteins play pivotal roles in driving fate switches of NPCs during neocortical development. Also, we identified a mechanism that couples neuronal fate commitment and neuronal migration. Further, we found that TCF3 suppresses Wnt signaling and maintains the undifferentiated state of NPCs.
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