| Budget Amount *help |
¥97,370,000 (Direct Cost: ¥74,900,000、Indirect Cost: ¥22,470,000)
Fiscal Year 2014: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2013: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2011: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
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| Outline of Final Research Achievements |
We aimed to decipher neural codes that regulate memory-based behavior, using the neural circuit underlying thermotaxis in C. elegans, as an ideal circuit system. We revealed that the major thermosensory neuron AFD can remember cultivation temperatures and that the temperature memory is modulated by CaMKI and raf kinase pathways in AFD neurons. Calcium imaging of AIY and RIA interneurons, which receive synaptic outputs from AFD and AIY, respectively, showed that AIY neurons convey the information of temperature memory in AFD to the downstream interneuron RIA, in which the magnitude and frequency of stochastic calcium response appeared to be shut down at the temperature that corresponds to the memorized temperature in AFD. Our results and previous studies altogether proposed the neural circuit model, in which the circuits for the head swing and dorso-ventral sinus curve body movement are coordinated through many interneurons with different functions.
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