| Budget Amount *help |
¥119,470,000 (Direct Cost: ¥91,900,000、Indirect Cost: ¥27,570,000)
Fiscal Year 2014: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2013: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2012: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2011: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2010: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
|
|---|
| Outline of Final Research Achievements |
When we removed the lower arm of newts at the elbow joint level, we found regeneration of a functional elbow joint within 70 days after amputation, although the size of the regenerating lower arm was still miniature compared to that of the remaining upper arm, suggesting the existence of a reintegration system between regenerating and remaining tissues during regeneration. Based on this finding, we have amputated frog arms at the joint level according to our experiments using newts, and we have succeeded in evoking functional joint regeneration from frog, in which nobody had observed joint regeneration after metamorphosis so far. That is, we have shown a new strategy to induce regeneration ability in "non-regenerative" animals. The remaining joint part in the upper arm may supply cells and produce factors to form a functional elbow joint. This became a landmark work for future regenerative medicine in the field of joint regeneration.
|
