General principles determinating organ-level regenerative capacity in vertebrates

• Project Area: Molecular mechanisms underlying reconstruction of 3D structers during regeneration
• Project/Area Number: 22124005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hirosaki University (2013, 2015); Tohoku University (2010-2012, 2014)
• Principal Investigator: YOKOYAMA Hitoshi 弘前大学, 農学生命科学部, 准教授 (90455816)
• Co-Investigator(Kenkyū-buntansha): TAMURA Koji 東北大学, 大学院生命科学研究科, 教授 (70261550)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥98,670,000 (Direct Cost: ¥75,900,000、Indirect Cost: ¥22,770,000); Fiscal Year 2014: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2013: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2012: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000); Fiscal Year 2011: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000); Fiscal Year 2010: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
• Keywords: 再生 / 四肢 / 皮膚 / 遺伝子操作 / 両生類 / 発生・分化 / 再生医学 / 発現制御 / 細胞・組織 / 遺伝子 / 器官形成 / ゼノパス(アフリカツメガエル) / 普遍原理 / 遺伝子組換え

Outline of Final Research Achievements

We aimed to reveal common principles of organ-level regeneration among animals by using Xenopus as the main model. Firstly, we focused on the anterior-posterior axis formation of a limb and elucidated the avian digit identity of fore- and hindlimb. We found that an adult (metamorphosed) Xenopus can regenerate its skin almost completely after deep injury while an adult mammal cannot regenerate its skin. We analyzed the function of Hippo signaling pathway in organ regeneration of Xenopus and provided evidence that underlies the common mechanism(s) among vertebrate and invertebrate animals. We also found that epigenetic modification of genome is stable during limb regeneration by genome-wide analysis of histone modification. We also developed new experimental techniques for local gene induction in amphibians.

Research Products

• [Journal Article] Evidence for an amphibian sixth digit. (2015)
  • Author(s): Hayashi S., Kobayashi T., Yano T., Kamiyama N., Egawa S., Seki R., Takizawa K., Okabe M., Yokoyama H. and Tamura K.
  • Journal Title: Zoological Letters. Volume: 1 Issue: 1 Pages: 17-17
  • DOI: 10.1186/s40851-015-0019-y
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic modification maintains intrinsic limb-cell identity in Xenopus limb bud regeneration. (2015)
  • Author(s): Hayashi, S., Kawaguchi, A., Uchiyama, I., Kawasumi-Kita, A., Kobayashi, T., Nishide, H., Tsutsumi, R., Tsuru, K., Inoue, T., Ogino, H., Agata, K., Tamura, K. and *Yokoyama, H.
  • Journal Title: Dev. Biol. Volume: 406 Issue: 2 Pages: 271-282
  • DOI: 10.1016/j.ydbio.2015.08.013
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] AP-2β is a transcriptional regulator for determination of digit length in tetrapods. (2015)
  • Author(s): Seki R, Kitajima K, Matsubara H, Suzuki T, Saito D, Yokoyama H, Tamura K.
  • Journal Title: Dev Biol. Volume: 407 Issue: 1 Pages: 75-89
  • DOI: 10.1016/j.ydbio.2015.08.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Application of local gene induction by infrared laser-mediated microscope and temperature stimulator to amphibian regeneration study. (2015)
  • Author(s): Kawasumi, A., Hayashi, T., Kobayashi, T., Nagayama, C., Hayashi, S., Kamei, Y., Morishita, Y., T Takeuchi, T., Tamura, K., Yokoyama, H.
  • Journal Title: Dev. Growth Differ. Volume: 57 Issue: 9 Pages: 601-613
  • DOI: 10.1111/dgd.12241
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Roles of Hippo signaling pathway in size control of organ regeneration (2015)
  • Author(s): Hayashi, S., Yokoyama, H. and Tamura, K.
  • Journal Title: Development Growth and Differentiation Volume: 未定 Issue: 4 Pages: 341-351
  • DOI: 10.1111/dgd.12212
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Developmental stages for the divergence of relative limb length between a twig and a trunk-ground Anolis lizard species (2015)
  • Author(s): Wakasa, H., Cadiz, A., Echenique-Diaz, L.M. Iwasaki, W.M. Kamiyama, N., Nishimura, Y., Yokoyama, H., Tamura, K. and Kawata, M.
  • Journal Title: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Volume: 未定 Issue: 5 Pages: 410-423
  • DOI: 10.1002/jez.b.22627
  • Peer Reviewed
• [Journal Article] アフリカツメガエルから見た四肢再生実現へのステップ (2014)
  • Author(s): 横山仁、林真一、川住愛子、砂川奈都召、田村宏治
  • Journal Title: 実験医学 Volume: 32 (1) Pages: 22-28
• [Journal Article] Yap1, transcription regulator in the Hippo signaling pathway, is required for Xenopus limb bud regeneration. (2014)
  • Author(s): Hayashi S, Tamura K, Yokoyama H
  • Journal Title: Developmental Biology Volume: 388 Issue: 1 Pages: 57-67
  • DOI: 10.1016/j.ydbio.2014.01.018
  • Peer Reviewed / Open Access
• [Journal Article] Altered developmental events in the anterior region of the chick forelimb give rise to avian-specific digit loss (2014)
  • Author(s): Naoki Nomura, Hitoshi Yokoyama and Koji Tamura
  • Journal Title: Developmental Dynamics Volume: published online Issue: 6 Pages: 741-52
  • DOI: 10.1002/dvdy.24117
  • Peer Reviewed / Open Access
• [Journal Article] Growth and differentiation of a long bone in limb development, repair and regeneration (2014)
  • Author(s): S. Egawa, S. Miura, H. Yokoyama, T. Endo and K. Tamura
  • Journal Title: Dev Growth Differ Volume: 56 Issue: 5 Pages: 410-24
  • DOI: 10.1111/dgd.12136
  • NAID: 40020109556
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration (2014)
  • Author(s): S. Hayashi, H. Ochi, H. Ogino, A. Kawasumi, Y. Kamei, K. Tamura and H. Yokoyama
  • Journal Title: Dev Biol Volume: 396 Issue: 1 Pages: 31-41
  • DOI: 10.1016/j.ydbio.2014.09.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Growth and differentiation of a long bone in limb development, repair and regeneration (2014)
  • Author(s): Egawa, S., Miura, S., Yokoyama, H., Endo, T., and Tamura, K.
  • Journal Title: Development Growth and Differentiation Volume: 未定
  • NAID: 40020109556
  • Peer Reviewed
• [Journal Article] 両生類の皮膚再生と四肢再生の関係から見る，両生類再生研究の哺乳類への応用の可能性 (2013)
  • Author(s): 田村宏治、大塚理奈、川住愛子、横山仁
  • Journal Title: 瘢痕・ケロイド治療ジャーナル Volume: 7 Pages: 1-4
• [Journal Article] 四肢再生における脱分化、再分化と細胞記憶 (2013)
  • Author(s): 林真一、矢野十織、川住愛子、田村宏治、横山仁
  • Journal Title: 実験医学 Volume: 31 (13) Pages: 2075-2082
• [Journal Article] Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals (2013)
  • Author(s): Kawasumi, A., Sagawa, N., Hayashi, S., Yokoyama, H., and Tamura, K.
  • Journal Title: Current Topics in Microbiology and Immunology Volume: 367 Pages: 33-49
  • DOI: 10.1007/82_2012_305
  • ISBN: 9783642358098, 9783642358104
  • Peer Reviewed
• [Journal Article] Heterochronically early decline of Hox expression prior to cartilage formation in the avian hindlimb zeugopod (2012)
  • Author(s): 神山菜美子
  • Journal Title: Development Growth and Differentiation Volume: 54 Issue: 6 Pages: 619-632
  • DOI: 10.1111/j.1440-169x.2012.01359.x
  • Peer Reviewed
• [Journal Article] Mechanism of Pectoral Fin Outgrowth in Zebrafish Development (2012)
  • Author(s): Yano, T., Abe, G., Yokoyama, H., Kawakami, K., and Tamura, K.
  • Journal Title: Development Volume: 139 Issue: 16 Pages: 2916-2925
  • DOI: 10.1242/dev.075572
  • Peer Reviewed
• [Journal Article] 四肢再生の基盤としての創傷治癒：両生類から学ぶ皮膚の完全再生 (2012)
  • Author(s): 横山仁、川住愛子、林真一、田村宏治
  • Journal Title: 細胞工学 Volume: 31(5) Pages: 592-599
  • NAID: 40019307547
• [Journal Article] Prx-1 Expression in Xenopus laevis Scarless Skin-Wound Healing and Its Resemblance to Epimorphic Regeneration (2011)
  • Author(s): Yokoyama H
  • Journal Title: J Invest Dermatol Volume: 131 Issue: 12 Pages: 477-485
  • DOI: 10.1038/jid.2011.223
  • Peer Reviewed
• [Journal Article] Different requirement for Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus. (2011)
  • Author(s): Yokoyama Hitoshi
  • Journal Title: PLoS One Volume: 6(7) Issue: 7 Pages: e21721-e21721
  • DOI: 10.1371/journal.pone.0021721
  • Peer Reviewed
• [Journal Article] 鳥類の指と恐竜の指は同じもの (2011)
  • Author(s): 野村直生
  • Journal Title: 細胞工学 Volume: 30 (12) Pages: 1301-1305
• [Journal Article] Embryological evidence identifies wing digits in birds as digits 1, 2, and 3 (2011)
  • Author(s): 田村宏治、野村直生、関亮平、米井(田村)小百合、横山仁
  • Journal Title: Science Volume: 331 Pages: 753-757
  • Peer Reviewed
• [Journal Article] Role of paraxial mesoderm in limb/flank regionalization of the trunk lateral plate (2011)
  • Author(s): 野呂美幸、湯口弘樹、佐藤妙子、對比地孝亘、米井(田村)小百合、横山仁、若松義雄、田村宏治
  • Journal Title: Developmental Dynamics Volume: 240 Pages: 1639-1649
  • Peer Reviewed
• [Journal Article] Prx-1 expression in Xenopus laevis scarless skin-wound healing and its resemblance to epimorphic regeneration (2011)
  • Author(s): 横山仁、丸岡玉枝、有賀章郎、天野孝紀、大湖史朗、城石俊彦、田村宏治
  • Journal Title: Journal of Investigative Dermatology Volume: 131 Pages: 2477-2485
  • Peer Reviewed
• [Journal Article] Different requirement for Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus (2011)
  • Author(s): 横山仁、丸岡玉枝、越智陽城、有賀章郎、大湖史朗、荻野肇、田村宏治
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Morphogenetic change of the limb bud in the hand plate formation (2010)
  • Author(s): 佐藤耕世、関亮平、野呂美幸、横山仁、田村宏治
  • Journal Title: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Volume: 314B Pages: 539-551
  • Peer Reviewed
• [Presentation] 四肢と皮膚の完全再生を可能にする分子・細胞メカニズムの探求 (2016)
  • Author(s): 横山仁
  • Organizer: 日本解剖学会 シンポジウム再生研究の新機軸 ―不可能を可能とする内在性プログラムの探索―
  • Place of Presentation: ビッグパレットふくしま（福島県郡山市）
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] Skin regeneration of Xenopus, as a model for scar-free skin regeneration in adulthood (2016)
  • Author(s): Hitoshi Yokoyama, Rina Otsuka, Aiko Kawasumi-Kita, Tamae Maruoka and Koji Tamura
  • Organizer: Aquatic model organisms for human disease and toxicology research
  • Place of Presentation: 岡崎コンファレンスセンター（愛知県岡崎市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research / Invited
• [Presentation] ツメガエルにおける局所的な遺伝子発現の操作法の確立と再生研究への応用 (2015)
  • Author(s): 横山仁, 川住愛子, 林利憲, 小林託也, 永山誓史, 林真一, 亀井保博, 森下喜弘, 竹内隆, 田村宏治
  • Organizer: 日本ツメガエル研究集会
  • Place of Presentation: 秋田温泉さとみ（秋田市）
  • Year and Date: 2015-09-15
• [Presentation] アフリカツメガエルを用いた皮膚再生の研究 ‐これまでとこれから‐ (2015)
  • Author(s): 横山仁
  • Organizer: 次世代両生類研究会
  • Place of Presentation: 岡崎コンファレンスセンター（愛知県岡崎市）
  • Year and Date: 2015-08-24
  • Invited
• [Presentation] アフリカツメガエルにおける皮膚の完全再生に寄与する細胞の起源 (2015)
  • Author(s): 大塚理奈, 有泉高史, 永山誓史, 川住愛子, 田村宏治, 横山仁
  • Organizer: 日本動物学会東北支部大会
  • Place of Presentation: 東北大学（仙台市）
  • Year and Date: 2015-08-09
• [Presentation] アフリカツメガエルにおける瘢痕を残さない皮膚再生 ‐再生に寄与する細胞はどこから来るのか？- (2015)
  • Author(s): 横山仁、大塚理奈、有泉高史、永山誓史、川住愛子、田村宏治
  • Organizer: 日本再生医療学会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2015-03-21
• [Presentation] Post embryonicなツメガエルにおける局所的な遺伝子発現の誘導について (2014)
  • Author(s): 横山仁
  • Organizer: イベリアトゲイモリ研究集会
  • Place of Presentation: 鳥取大学（米子市）
  • Year and Date: 2014-12-05
• [Presentation] ゼノパスの尾再生におけるHippo経路の転写制御因子による器官再形成の制御 (2014)
  • Author(s): 林真一、越智陽城、荻野肇、川住愛子、亀井保博、田村宏治、横山仁
  • Organizer: 日本動物学会
  • Place of Presentation: 東北大学（仙台市）
  • Year and Date: 2014-09-11
• [Presentation] Cellular origin of blastema-like cells contributing to scarless skin regeneration of metamorphosed Xenopus laevis (2014)
  • Author(s): Rina Otsuka, Chikashi Nagayama, Aiko Kawasumi, Takashi Ariizumi, Koji Tamura, Hitoshi Yokoyama
  • Organizer: 日本発生生物学会
  • Place of Presentation: ウィンクあいち
  • Year and Date: 2014-05-28 – 2014-05-29
• [Presentation] Epigenetic modification underlies recapitulation of limb-specific gene expression in Xenopus limb bud regeneration (2014)
  • Author(s): Shinich Hayashi, Ikuo Uchiyama, Koji Tamura, Hitoshi Yokoyama
  • Organizer: 日本発生生物学会
  • Place of Presentation: ウィンクあいち
  • Year and Date: 2014-05-28 – 2014-05-29
• [Presentation] Yap1, Transcription Regulator in the Hippo Signaling Pathway, is Required for Xenopus Limb Bud Regeneration (2014)
  • Author(s): Shinichi Hayashi, Haruki Ochi, Hajime Ogino, Koji Tamura, Hitoshi Yokoyama
  • Organizer: CDBシンポジウム2014 "Regeneration of Organs: Programming and Self-Organization”
  • Place of Presentation: 理化学研究所 発生・再生科学総合研究センター（RIKEN CDB）（神戸）
  • Year and Date: 2014-03-11
• [Presentation] アフリカツメガエルの四肢再生におけるHippo経路下流の転写因子Yapの重要性 (2014)
  • Author(s): 林真一、越智陽城、荻野肇、田村宏治、横山仁
  • Organizer: 日本再生医療学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-03-04
• [Presentation] Yap1, Transcription Regulator in the Hippo Signaling Pathway, is Required for Xenopus Limb Bud Regeneration (2014)
  • Author(s): Shinichi Hayashi, Haruki Ochi, Hajime Ogino, Koji Tamura, Hitoshi Yokoyama
  • Organizer: CDBシンポジウム 2014 "Regeneration of Organs: Programming and Self-Organization"
  • Place of Presentation: 理化学研究所 発生・再生科学総合研究センター（RIKEN CDB） (神戸)
• [Presentation] 発生原理から見たアフリカツメガエルの器官再生 (2013)
  • Author(s): 横山仁
  • Organizer: 日本動物学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2013-09-26
  • Invited
• [Presentation] アフリカツメガエルの四肢再生におけるHippo経路の機能解析 (2013)
  • Author(s): 林真一、越智陽城、荻野肇、田村宏治、横山仁
  • Organizer: 日本動物学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2013-09-26
• [Presentation] Hippo signaling is important for Xenopus limb regeneration (2013)
  • Author(s): 林真一、越智陽城、荻野肇、田村宏治、横山仁
  • Organizer: 日本発生生物学会
  • Place of Presentation: くにびきメッセ（島根県松江市）
  • Year and Date: 2013-05-30
• [Presentation] Different cellular contribution of somite-derived tissues to limb regeneration in larval and adult Xenopus (2013)
  • Author(s): 永山誓史、有泉高史、田村宏治、横山仁
  • Organizer: 日本発生生物学会
  • Place of Presentation: くにびきメッセ（島根県松江市）
  • Year and Date: 2013-05-30
• [Presentation] 両生類から学ぶ皮膚の完全再生 ‐瘢痕を作らない成体での創傷治癒‐ (2013)
  • Author(s): 横山仁、大塚理奈、丸岡玉枝、川住愛子、林真一、天野 孝紀、城石俊彦、田村宏治
  • Organizer: 日本再生医療学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] アフリカツメガエル四肢再生におけるHippo 系路の機能解析 (2013)
  • Author(s): 林真一、越智陽城、荻野肇、田村宏治、横山仁
  • Organizer: 日本動物学会
  • Place of Presentation: 岡山大学
• [Presentation] アフリカツメガエル四肢再生におけるHippo経路下流の転写因子Yapの重要性 (2013)
  • Author(s): 林真一、越智陽城、荻野肇、田村宏治、横山仁
  • Organizer: 日本再生医療学会
  • Place of Presentation: 国立京都国際会館 (京都)
• [Presentation] 両生類から学ぶ皮膚の完全再生 ‐瘢痕を作らない成体での創傷治癒‐ (2013)
  • Author(s): 横山仁
  • Organizer: 日本再生医療学会
  • Place of Presentation: 横浜
• [Presentation] Different cellular contribution of somite-derived tissues to limb regeneration in larval and adult Xenopus (2013)
  • Author(s): 横山仁
  • Organizer: 日本発生生物学会
  • Place of Presentation: 松江
• [Presentation] いまだ未知なる両生類の世界 -秘められた治癒能力- (2012)
  • Author(s): 横山仁、田村宏治
  • Organizer: 日本動物学会
  • Place of Presentation: 大阪大学
  • Invited
• [Presentation] Limb Regeneration of Xenopus as a Model for Three-dimensional Appendage/Organ Regeneration (2011)
  • Author(s): 横山仁、丸岡玉枝、越智陽樹、有賀章郎、天野孝紀、城石俊彦、荻野肇、田村宏治
  • Organizer: 第21回CDBミーティングThe 1st CDB-Regeneration Biology Study Group meeting "from Regeneration Biology to Regenerative Medicine (I)"
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-25
• [Presentation] 両生類における皮膚の再生-四肢再生の基盤として- (2011)
  • Author(s): 横山仁、丸岡玉枝、越智陽樹、林真一、有賀章郎、天野孝紀、城石俊彦、荻野肇、田村宏治
  • Organizer: 日本ツメガエル研究集会
  • Place of Presentation: 熱海
  • Year and Date: 2011-10-06
• [Presentation] Scarless wound healing of Xenopus laevis-as a prerequisite for epimorphic regeneration- (2011)
  • Author(s): 横山仁、丸岡玉枝、越智陽城、有賀章郎、天野孝紀、城石俊彦、荻野肇、田村宏治
  • Organizer: 日本発生生物学会
  • Place of Presentation: 宜野湾
  • Year and Date: 2011-05-19
• [Presentation] Limb regeneration of Xenopus as a model for three-dimensional appendage/organ regeneration (2011)
  • Author(s): 横山仁
  • Organizer: The 2nd UCL-Tohoku University Symposium "From Cell/Developmental Biology to Neuroscience"
  • Place of Presentation: 仙台
  • Year and Date: 2011-01-23
• [Presentation] Scarless wound healing of Xenopus laevis -as a prerequisite for epimorphic regeneration- (2011)
  • Author(s): 横山仁
  • Organizer: 日本発生生物学会
  • Place of Presentation: 宜野湾
  • Invited
• [Presentation] Wntシグナリングはツメガエルの四肢再生に対して幼生期と成体期で異なる関与をする (2011)
  • Author(s): 横山仁
  • Organizer: 日本動物学会
  • Place of Presentation: 旭川
• [Presentation] 両生類における皮膚の再生－四肢再生の基盤として－ (2011)
  • Author(s): 横山仁
  • Organizer: 日本ツメガエル研究集会
  • Place of Presentation: 熱海
• [Presentation] Limb Regeneration of Xenopus as a Model for Three-dimensional Appendage/ Organ Regeneration (2011)
  • Author(s): 横山仁
  • Organizer: 第21回CDBミーティング The 1st CDB-Regeneration Biology Study Group meeting "from Regeneration Biology to Regenerative Medicine (I)"
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Different involvement of Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus (2010)
  • Author(s): 横山仁、丸岡玉枝、越智陽城、有賀章郎、大湖史朗、荻野肇、田村宏治
  • Organizer: EMBO Conference on the Molecular & Cellular Basis of Regeneration & Tissue Repair
  • Place of Presentation: セジンブラ、ポルトガル
  • Year and Date: 2010-09-29
• [Presentation] 幼生期と成体期のXenopusでみられる四肢再生における異なる開始機構 (2010)
  • Author(s): 横山仁、丸岡玉枝、越智陽城、有賀章郎、大湖史朗、荻野肇、田村宏治
  • Organizer: 日本動物学会東北支部大会
  • Place of Presentation: 福島県立医科大学
  • Year and Date: 2010-08-07
• [Presentation] 幼生期と成体期のアフリカツメガエルでみられる四肢再生における異なる開始機構(Different mechanisms in initiation of limb regeneration between larval and adult Xenopus) (2010)
  • Author(s): 横山仁、大湖史朗、有賀章郎、丸岡玉枝、越智陽城、荻野肇、田村宏治
  • Organizer: 日本発生生物学会
  • Place of Presentation: 京都
• [Remarks] 弘前大学農学生命科学部教員紹介ページ
  • URL: http://nature.cc.hirosaki-u.ac.jp/staff/hitoshi-yokoyama
• [Remarks] 弘前大学農学生命科学部教員紹介
  • URL: http://nature.cc.hirosaki-u.ac.jp/public/hitoshi-yokoyama/
• [Remarks] 田村研ホームページ 横山仁 研究業績リスト
  • URL: http://www.biology.tohoku.ac.jp/lab-www/tamlab/members/yoko_pub.html
• [Remarks] 東北大学 大学院生命科学研究科 教員紹介ページ 横山仁
  • URL: http://www.lifesci.tohoku.ac.jp/teacher/t_yokoyamaj/
• [Remarks] 東北大学 大学院生命科学研究科 器官形成分野 田村研究室
  • URL: http://www.biology.tohoku.ac.jp/lab-www/tamlab/index.html
• [Remarks] 新学術領域研究「再生原理」
  • URL: http://reg.biol.sci.kyoto-u.ac.jp/repo/results.html
• [Remarks]
  • URL: http://www.biology.tohoku.ac.jp/lab-www/tamlab/index.html
• [Remarks]
  • URL: http://reg.biol.sci.kyoto-u.ac.jp/repo/results.html