| Budget Amount *help |
¥109,460,000 (Direct Cost: ¥84,200,000、Indirect Cost: ¥25,260,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2013: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2012: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2011: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2010: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
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| Outline of Final Research Achievements |
A fundamental reaction step of fission yeast mating-type (MT) switching is a gene conversion that is driven with a strict polarity. This polarity control is closely related to heterochromatin formation and genetic imprinting at the mat locus. In the research project, we aimed to understand molecular mechanism of MT switching mainly by analyzing chromosome dynamics at the mat locus. ChIP-Seq analysis has revealed that Swi2 localizations at mat locus are uniquely different between two different-MT cells. In addition, 3C analysis has also indicated that chromosome configurations are different in the two different-MT cells.
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