| Budget Amount *help |
¥73,320,000 (Direct Cost: ¥56,400,000、Indirect Cost: ¥16,920,000)
Fiscal Year 2014: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2013: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2012: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2011: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2010: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
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| Outline of Final Research Achievements |
Here we investigated the molecular mechanisms of chromosomal reorganization occurred to our previously-developed model chromosome system in fission yeast that recapitulates the spontaneous adaptation response toward a collapse of genome transmission function in the chromosomes. Through this study, we uncovered that the eukaryotic chromosomal termini are generally advantageous in producing flexible and adaptive chromosomal responses to achieve preservation of entire genome contents, and that the centromeres are newly established at ectopic positions in a stepwise manner allowing diverse and elastic ways of their functional maturation to fit to the local chromosomal environment.
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