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Adaptation in the structure and function of the chromosomes that ensures genome transmission across generations

Planned Research

Project AreaSystematic study of chromosome adaptation
Project/Area Number 22125004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

ISHII Kojiro  大阪大学, 生命機能研究科, 特任准教授 (40360276)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥73,320,000 (Direct Cost: ¥56,400,000、Indirect Cost: ¥16,920,000)
Fiscal Year 2014: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2013: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2012: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2011: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2010: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Keywordsゲノム / 染色体 / セントロメア / テロメア / 減数分裂
Outline of Final Research Achievements

Here we investigated the molecular mechanisms of chromosomal reorganization occurred to our previously-developed model chromosome system in fission yeast that recapitulates the spontaneous adaptation response toward a collapse of genome transmission function in the chromosomes. Through this study, we uncovered that the eukaryotic chromosomal termini are generally advantageous in producing flexible and adaptive chromosomal responses to achieve preservation of entire genome contents, and that the centromeres are newly established at ectopic positions in a stepwise manner allowing diverse and elastic ways of their functional maturation to fit to the local chromosomal environment.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (27 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Invited: 7 results) Book (1 results) Remarks (1 results)

  • [Journal Article] The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin2014

    • Author(s)
      T. Kitagawa, K. Ishii, K. Takeda, T. Matsumoto
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 3597-3597

    • DOI

      10.1038/ncomms4597

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epigenetically induced paucity of histone H2A. 2 stabilizes fission-yeast ectonic centoromeres2013

    • Author(s)
      Ogiyama Y, Ohno Y, Kubota Y, Ishii K
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: vol.20 Issue: 12 Pages: 1397-1406

    • DOI

      10.1038/nsmb.2697

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The smooth and stable operation of centromeres2012

    • Author(s)
      荻山友貴
    • Journal Title

      Genes and Genetic Systems

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomere-engaged chromosome reorganization after centromere deletion in fission yeast2010

    • Author(s)
      荻山友貴、石井浩二郎
    • Journal Title

      Advance in Chromosome Science

      Volume: 3 Pages: 76-78

    • Related Report
      2010 Annual Research Report
  • [Presentation] 分裂酵母ヒストンH2Aバリアントのセントロメアでの働き2015

    • Author(s)
      石井浩二郎
    • Organizer
      第2回ヒストンバリアント研究会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 酵母LTR因子と染色体編成変化2015

    • Author(s)
      石井浩二郎
    • Organizer
      国立遺伝学研究所研究会「転移因子と宿主の相互作用による生命進化」
    • Place of Presentation
      静岡県三島市
    • Year and Date
      2015-02-26 – 2015-02-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Immediate cellular response to chromosomal aneuploidy2014

    • Author(s)
      Kojiro Ishii
    • Organizer
      4D Nucleome 2014
    • Place of Presentation
      広島県廿日市市
    • Year and Date
      2014-12-17 – 2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 染色体異数性に対する初期応答2014

    • Author(s)
      石井浩二郎
    • Organizer
      第32回染色体ワークショップ
    • Place of Presentation
      広島県廿日市市
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] De novo generation of heterochromatic siRNAs in fission yeast2014

    • Author(s)
      Kojiro Ishii
    • Organizer
      The 16th Tokyo RNA Club
    • Place of Presentation
      東京都文京区
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 宿主の染色体伝達欠損に伴うトランスポゾン制御変化2014

    • Author(s)
      石井浩二郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 染色体異数性の初期応答2014

    • Author(s)
      石井浩二郎
    • Organizer
      日本遺伝学会第86回大会
    • Place of Presentation
      滋賀県長浜市
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chromosomal reorganizations after centromere dysfunction2013

    • Author(s)
      Kojiro Ishii
    • Organizer
      International Symposium “Message from Yeast to Epigenetics”
    • Place of Presentation
      グランディア芳泉(福井)
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] 機能欠損染色体が生み出す細胞応答2013

    • Author(s)
      石井浩二郎
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶応大学(神奈川)
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] セントロメアの欠損に付随した染色体編成のダイナミクス2013

    • Author(s)
      石井浩二郎
    • Organizer
      国立遺伝学研究所研究会「染色体DNAの安定維持の分子メカニズム」
    • Place of Presentation
      国立遺伝学研究所(静岡)
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] 分裂酵母を用いた自発的な染色体再編成機構の解析2013

    • Author(s)
      石井浩二郎
    • Organizer
      第22回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      ホテルニュー三戸屋(仙台)
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Presentation] Ectopic centromere formation is completed with neighboring heterochromatin2012

    • Author(s)
      石井浩二郎
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      ホテルニュー水戸屋(宮城県)
    • Year and Date
      2012-01-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chromosomal reorganizations provoked by centromere dysfunction2011

    • Author(s)
      石井浩二郎
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜国際会議場(神奈川県)(招待講演)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 染色体高次機能構築の制御機構2011

    • Author(s)
      石井浩二郎
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都大学農学部(京都府)(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ネオセントロメア形成の分子基盤2011

    • Author(s)
      石井浩二郎
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都大学農学部(京都府)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 染色体編成はどうやって変化するのか?2011

    • Author(s)
      石井浩二郎
    • Organizer
      第23回高遠シンポジウム
    • Place of Presentation
      高遠さくらホテル(長野県)(招待講演)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous chromosome reorganizations after centromere dysfunction2011

    • Author(s)
      石井浩二郎
    • Organizer
      The 6^<th> International Fission Yeast Meeting
    • Place of Presentation
      Martin Conference Center, Boston(アメリカ)
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] A molecular mechanism for de novo siRNA generation in fission yeast2011

    • Author(s)
      石井浩二郎
    • Organizer
      The 16^<th> Annual Meeting of the RNA Society
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2011-06-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous reorganization of acentric chromosomes2011

    • Author(s)
      石井浩二郎
    • Organizer
      The 6^<th> UK Japan Cell Cycle Workshop
    • Place of Presentation
      Low Wood Hotel, Windermere(イギリス)
    • Year and Date
      2011-04-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous reorganization of acentric chromosome2011

    • Author(s)
      石井浩二郎
    • Organizer
      International Symposium on the Physicochemical Field for Grenetic Activities
    • Place of Presentation
      兵庫県淡路市
    • Year and Date
      2011-01-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] テロメアとセントロメアに導かれる染色体再編成2010

    • Author(s)
      石井浩二郎
    • Organizer
      第33回日本分子生物学会年会BMB2010
    • Place of Presentation
      兵庫県神戸市(招待講演)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Book] エピジェネティクス2010

    • Author(s)
      石井浩二郎(共訳)
    • Publisher
      培風館
    • Related Report
      2010 Annual Research Report
  • [Remarks] 石井研ホームページ

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/ishii/index.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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