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Role of stress-induced epigenetic change in genome adaptation

Planned Research

Project AreaSystematic study of chromosome adaptation
Project/Area Number 22125005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ISHII Shunsuke  独立行政法人理化学研究所, 石井分子遺伝学研究室, 上席研究員 (00124785)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥129,870,000 (Direct Cost: ¥99,900,000、Indirect Cost: ¥29,970,000)
Fiscal Year 2014: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2013: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2012: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2011: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2010: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Keywordsエピゲノム / 遺伝 / ストレス / 環境要因 / エオイジェネティクス / テロメア / 寿命 / ATF7 / 疾患 / エピジェネティクス / ATF-2 / エピジェネティック変化 / ヘテロクロマチン / ヒストン / H3-K9メチル化 / ゲノム / 適応 / ヒストン修飾 / ATF-7 / エピジェネテクス
Outline of Final Research Achievements

It was shown that transcription factor ATF-2 mediates the heat shock stress-induced epigenetic change which is transmitted to next generation. The ATF-2 family transcription factors are also involved in the innate immune memory and the psychological stress-induced telmere shortening. Furthermore, they mediates the epigenome change induced by nutritional condition and psychological stress which are transmitted to next generation. Thus, ATF-2 family transcription afctors contribute to the epigenome change induced by various environmental factors and its inheritance.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (22 results) (of which Invited: 4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Disruption of Th2a and Th2b genes causes defects in spermatogenesis.2015

    • Author(s)
      Shinagawa, H. et al.
    • Journal Title

      Development

      Volume: 142 Pages: 1287-1292

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.2015

    • Author(s)
      Makino, S. et al.
    • Journal Title

      PLoS One

      Volume: 10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells2014

    • Author(s)
      Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii S
    • Journal Title

      Cell Stem Cell

      Volume: 14(2) Issue: 2 Pages: 217-227

    • DOI

      10.1016/j.stem.2013.12.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis.2013

    • Author(s)
      1. Zaman MM, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, Tanaka Y, Ishii S
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 24 Pages: 4971-4984

    • DOI

      10.1128/mcb.00465-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trim27-deficient mice are susceptible to streptozotocin-induced diabetes.2013

    • Author(s)
      Zaman MM, Ishii S 他
    • Journal Title

      FEBS Open Bio.

      Volume: 4 Issue: 1 Pages: 60-64

    • DOI

      10.1016/j.fob.2013.12.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk2013

    • Author(s)
      Seong KH & Ishii S
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 1 Pages: 66-78

    • DOI

      10.1111/gtc.12018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013

    • Author(s)
      Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38(8) Issue: 8 Pages: 1409-25

    • DOI

      10.1038/npp.2013.38

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inheritance and memory of stress-induced epigenome change : roles played by the ATF-2 family of transcription factors2012

    • Author(s)
      Seong KH, Maekawa T & Ishii S
    • Journal Title

      Genes Cells

      Volume: 17 Issue: 4 Pages: 249-263

    • DOI

      10.1111/j.1365-2443.2012.01587.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation2012

    • Author(s)
      Kanei-Ishii C, Nomura T, Egoh A & Ishii S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 426 Issue: 1 Pages: 59-64

    • DOI

      10.1016/j.bbrc.2012.08.032

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inheritance and memory of stress-induced epigenome change : roles played by the ATF-2 family of transcription factors2012

    • Author(s)
      Seong KH, Maekawa T, Ishii S
    • Journal Title

      Genes to Cells

      Volume: 17(In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inheritance of stress-induced, ATF-2-dependent epigenetic change2011

    • Author(s)
      Seong KH, Li D, Shimizu H, Nakamura R, Ishii S
    • Journal Title

      Cell

      Volume: 145 Issue: 7 Pages: 1049-1061

    • DOI

      10.1016/j.cell.2011.05.029

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dampening of death pathways by schnurri-2 is essential for T-cell development2011

    • Author(s)
      Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S, Glimcher LH
    • Journal Title

      Nature

      Volume: 472 Issue: 7341 Pages: 105-109

    • DOI

      10.1038/nature09848

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy.2011

    • Author(s)
      Nagao M., et al.
    • Journal Title

      J Cell Physiol

      Volume: 226 Pages: 573-578

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional knockdown of target gene expression by tetracycline regulated transcription of double strand RNA.2011

    • Author(s)
      Hou, X., et al.
    • Journal Title

      Dev Growth Differ.

      Volume: 53 Pages: 69-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dampening of death pathways by Schnurri-2 is essential for T cell development.2011

    • Author(s)
      Staton, T.L., et al.
    • Journal Title

      Nature

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.2010

    • Author(s)
      Maekawa, T., et al.
    • Journal Title

      EMBO J.

      Volume: 29 Pages: 196-208

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of ATF-2 family transcription factors in adipocyte differentiation : anti-obesity effects of p38 inhibitors.2010

    • Author(s)
      Maekawa, T., et al.
    • Journal Title

      Mol.Cell.Biol.

      Volume: 30 Pages: 613-625

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.2010

    • Author(s)
      Jones, D.C., et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 107 Pages: 8254-8258

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.2010

    • Author(s)
      Seong, K.H., et al.
    • Journal Title

      PLOS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 転写因子ATF7を介したストレスによるテロメアの長さの制御2014

    • Author(s)
      前川利男、Liu Binbin、吉田圭介、仲村賢一、田久保海誉、石井俊輔
    • Organizer
      第37回に本分子生物学会年会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 父親への拘束ストレスによるエピゲノム変化と遺伝の解析2014

    • Author(s)
      成耆鉉、石井俊輔
    • Organizer
      第37回に本分子生物学会年会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 精子形成におけるヒストンバリアントTH2AとTH2Bの役割2014

    • Author(s)
      品川敏恵、Huynh Linh My、高木豪、塚本大輔、都丸千夏、野口純子、石井俊輔
    • Organizer
      第37回に本分子生物学会年会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inheritance of stress-induced chromatin alterations.2013

    • Author(s)
      Ishii S
    • Organizer
      Gordon Conference on Epigenetics
    • Place of Presentation
      Bryant University, Smithfield, RI, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ATF-7 controls epigenetic memory of pathogen infection in macrophages.2013

    • Author(s)
      Yoshida K, Ishii S 他
    • Organizer
      Gordon Conference on Epigenetics
    • Place of Presentation
      Bryant University, Smithfield, RI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inheritance of stress-induced epigenome changes.2013

    • Author(s)
      Ishii S
    • Organizer
      Small RNAs to Stem Cells & Epigenetic Reprograming Asia-2013 Meeting
    • Place of Presentation
      Univ. of Tokyo, Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 拘束ストレスにより誘導されるエピゲノム変化の遺伝2013

    • Author(s)
      成耆鉉、石井俊輔
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御2013

    • Author(s)
      前川利男、石井俊輔 他
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 卵子に大量に存在するヒストンバリアントによる 核のリプログラミング2013

    • Author(s)
      品川敏恵、石井俊輔 他
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates TNF-α-induced apoptosis2013

    • Author(s)
      Zaman MM, Ishii S 他
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of ATF-2 family transcription factors in inheritance of epigenetic change induced by stress2012

    • Author(s)
      石井俊輔
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエにおけるストレス依存的エピジェネティック制御とその遺伝の解析2012

    • Author(s)
      成耆鉉
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] マクロファージの炎症時におけるATF-7の機能解析2012

    • Author(s)
      吉田圭介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御2012

    • Author(s)
      前川利男
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia2012

    • Author(s)
      宮川剛
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] ストレスによるエピゲノム変化の遺伝2012

    • Author(s)
      石井俊輔
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ストレスはATF-7を介してヘテロクロマチン形成とテロメアの長さを制御する2011

    • Author(s)
      前川利男, 吉田圭介, Binbin Liu, 仲村賢一, 田久保海誉, 石井俊輔
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] ATF-7は炎症の抑制因子として機能する2011

    • Author(s)
      吉田圭介, 前川利男, Claire Renard-Guillet, 白髭克彦, 石井俊輔
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inheritance of stress-induced epigenome change :research using fly and mouse2011

    • Author(s)
      石井俊輔
    • Organizer
      第34回日本分子生物学会年会ワークショップ
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 環境・代謝ストレスによるエピジェネティック変化と疾患2011

    • Author(s)
      石井俊輔
    • Organizer
      第2回Molecular Cardiovascular Conference II
    • Place of Presentation
      小樽(招待講演)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ATF-2ファミリー転写因子とエピジェネティック制御2010

    • Author(s)
      石井俊輔
    • Organizer
      阪大蛋白研セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Inheritance of stress-induced epigenetic change2010

    • Author(s)
      石井俊輔
    • Organizer
      第15回東大・分生研シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.riken.go.jp/r-world/info/release/press/2011/110624/detail.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] Methods for generating nuclear reprogrammed cell, and use thereof.2012

    • Inventor(s)
      品川敏恵、石井俊輔
    • Industrial Property Rights Holder
      品川敏恵、石井俊輔
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-08-29
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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