| Budget Amount *help |
¥88,400,000 (Direct Cost: ¥68,000,000、Indirect Cost: ¥20,400,000)
Fiscal Year 2014: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2013: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2012: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2011: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2010: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Outline of Final Research Achievements |
Food selection, which is essential to maintain metabolic homeostasis, is modulated by nutritional state, food palatability and social life events such as stress. Here we show that AMP-activated protein kinase (AMPK) in a subset of corticotropin-releasing hormone (CRH) positive neurons in the paraventricular hypothalamus (PVH) regulates selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) in mice after fasting. Activation of AMPK in these CRH neurons was necessary and sufficient for mice to increase selection of a HCD and reduce that of a HFD. Our results thus provide important insight into the regulation of food selection behavior under physiological and pathological conditions.
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