| Budget Amount *help |
¥93,730,000 (Direct Cost: ¥72,100,000、Indirect Cost: ¥21,630,000)
Fiscal Year 2014: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2010: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
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| Outline of Final Research Achievements |
We have recently discovered that neuronal networks among organs/tissues play important roles in maintaining metabolic homeostasis in the whole body. In this study, we first focused on the inter-organ neuronal network system, originated in hepatic PPARγ expression, which promotes energy expenditure and lipolysis, and found that FSP27 mediates this signal downstream from PPARγ in the liver. Next, we newly discovered another inter-ogran communication system which regulates energy metabolism originating in the liver. Hepatic glucokinase expression, which induces glucose uptake, suppressed brown adipose tissue activity and adaptive thermogenesis via a novel neuronal network, consisting of the vagal afferents and sympathetic efferents. Furthermore, this neuronal network determines obesity predisposition among murine strains. Collectively, these discoveries further highlight the importance of inter-organ neuronal network for regulation of systemic homeostasis.
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